The impact of obesity on surgical staging, complications, and survival with uterine cancer: A Gynecologic Oncology Group LAP2 ancillary data study

Gunderson, Camille C.; Java, J.; Moore, Kathleen N.; Walker, Joan L.

doi:10.1016/j.ygyno.2014.01.041

Cited by 117 publications

(117 citation statements)

References 14 publications

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“…This indicates that obesity is not an obstacle for performing both open and laparoscopic surgery for endometrial cancer. A higher post-operative complication rate was observed in the higher BMI groups as the frequency of these complications increased significantly at a BMI higher than 30 for the duration of the use of antibiotics, and at 35 for venous thrombophlebitis and wound infection (14). The etiology of the difference in postoperative complications between Western studies and our study might be due to the fact that Korean patients are less obese compared to those patients in Western studies.…”

Section: Discussioncontrasting

confidence: 42%

“…However, the influence of a high BMI on the prognosis of endometrial carcinoma remains controversial. Obesity has been associated with a worse prognosis of endometrial carcinoma in several published studies, although there was no association in other and in Korean population studies (10)(11)(12)(13)(14). Obesity was once a contraindication for advanced laparoscopic procedures (15,16), although this has recently been reconsidered (17).…”

Section: Introductionmentioning

confidence: 99%

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Feasibility and Safety of Laparoscopic Surgery for Obese Korean Women with Endometrial Cancer: Long-Term Results at a Single Institution

Baek

Suk

Jung

et al. 2014

Journal of Minimally Invasive Gynecology

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The purpose of this study was to evaluate the surgical feasibility of and survival outcome after laparoscopy in obese Korean women with endometrial cancer which has recently been increasing. We reviewed the medical records of the patients treated at our medical institution between 1999 and 2012. The patients were divided into three groups, nonobese (Body Mass Index [BMI] < 25.0), overweight (BMI 25-27.99), and obese (BMI ≥ 28.0). These patient groups were compared in terms of their clinical characteristics, treatment methods, as well as surgical and survival outcomes. In total, 55 of the 278 eligible patients were obese women. There were no differences in the three groups in terms of the proportion of patients who underwent lymphadenectomy, their cancer stage, histologic type, type of adjuvant treatment administered, intra-, post-operative, and longterm complications, operative time, number of removed lymph nodes, blood loss, and duration of hospitalization (P = 0.067, 0.435, 0.757, 0.739, 0.458, 0.173, 0.076, 0.124, 0.770, 0.739, and 0.831, respectively). The Disease-Free Survival (DFS) times were 139.1 vs. 121.6 vs. 135.5 months (P = 0.313), and the Overall Survival (OS) times were 145.2 vs. 124.8 vs. 139.5 months (P = 0.436) for each group, respectively. Obese women with endometrial cancer can, therefore, be as safely managed using laparoscopy as women with normal BMIs.

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Section: Discussioncontrasting

confidence: 42%

Section: Introductionmentioning

confidence: 99%

Feasibility and Safety of Laparoscopic Surgery for Obese Korean Women with Endometrial Cancer: Long-Term Results at a Single Institution

Baek

Suk

Jung

et al. 2014

Journal of Minimally Invasive Gynecology

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“…The conversion to laparotomy occurred in 25.8% of cases, primarily because of poor exposure, and was dependent on BMI (17.5% among patients with a BMI of 25 or less, 26.5% among patients with a BMI of 34-35, and 57.1% among patients with a BMI greater than 40). Complication rates were similar regardless of the surgical approach [25,26].…”

Section: Discussionmentioning

confidence: 84%

“…The largest randomized study to date, comparing laparoscopy to laparotomy, the GOG Lap2 study, gave us an insight into the advantages of conventional laparoscopy over laparotomy when treating endometrial cancer [10,25,26]. The results showed that laparoscopic surgery is feasible and safe.…”

Section: Discussionmentioning

confidence: 99%

Perioperative Outcomes in Robotic-Assisted Versus Conventional Laparoscopic Treatment of Endometrial Cancer

Nezhat¹,

Apostol²,

Vega³

et al. 2016

J Adenocarcinoma

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“…Новые техники хирургического лечения -активное тиражирование эндовидеохирургии -не улучшили отдаленные ре-зультаты лечения. В недавно выполненном под кон-тролем Gynecologic Oncology Group (GOG) проспек-ОБЗОРЫ ПО КЛИНИЧЕСКОЙ ФАРМАКОЛОГИИ И ЛЕКАРСТВЕННОЙ ТЕРАПИИ 2016/14/2 тивном клиническом исследовании LAP2 (n = 2596) частота рецидивов заболевания в течение трех лет наблюдения у пациентов с I-IIA стадией рака тела мат-ки (n = 2181) после хирургического лечения лапаро-скопическим или лапаротомным доступом составила 11,4 и 10,2 % соответственно (p > 0,5) [2]. Пятилетняя выживаемость пациентов с распространенным ра-ком эндометрия, получивших комплексное лечение, составляет 30-40 % и 60-70 % при изолированном метастатическом поражении парааортальных и та-зовых лимфоузлов соответственно, что получило от-ражение в классификации TNM 7-го пересмотра [3].…”

Section: Introductionunclassified

Aromatase inhibitors of the third generation in endocrine therapy of breast cancer and endometrial cancer: the successes and failures of the combination therapy

Fadeeva

Павловна²,

Lisyanskaya

et al. 2016

Rev Clin Pharm Drug Ther

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Поступила в редакцию 12. 05.2016 Принята к печати 10. 06.2016 Ключевые слова:рак молочной железы; рак тела матки; лечение; ингибиторы ароматазы III поколения; тамоксифен. РезюмеОбзор обобщает современные данные клинических исследо-ваний, посвященных эффективности эндокринной терапии рака молочной железы и рака тела матки, включая эндоме- триальную стромальную саркому, ингибиторами аромата-зы (ИА) III поколения. В обзоре представлены данные кли-нических исследований, сравнивающих эффективность ИА и тамоксифена, а также данные о комбинированной терапии ИА с ингибиторами mTOR-пути (протокол BOLERO-2), с антиэстрогенами (протоколы SWOG S0226, FACT, FIRST), ингибитором CDK4/6 (протокол PALOMA-1) и другими пре-паратами. AROMATASE INHIBITORS OF THE THIRD GENERATION IN ENDOCRINE THERAPY OF BREAST CANCER AND ENDOMETRIAL CANCER: THE SUCCESSES AND FAILURES OF THE COMBINATION THERAPYKeywords:  breast cancer; endometrial cancer; therapy; aromatase inhibitors of III generation; tamoxifen. Abstract. This review provides the current evidence of clinical studies on the effectiveness of endocrine therapy for breast cancer and endometrial cancer, including endometrial stromal sarcoma, by aromatase inhibitor (AI) III generation. The review presents dates from clinical trials comparing the effectiveness of AI and tamoxifen, as well as dates on combination therapy AI with inhibitors of mTOR pathway (BOLERO-2 trial), an antiestrogen (SWOG S0226, FACT, FIRST trials), an inhibitor of CDK4 / 6 (PALOMA -1 trial) and other drugs. ВВЕДЕНИЕРак эндометрия (РЭ) представляет собой не толь-ко клиническую, но и социально-экономическую про-блему, так как инцидентность данного заболевания вместе с другими гормонально зависимыми опу-холями в Российской Федерации за последние не-сколько десятков лет увеличилась более чем в 2 раза, причем результаты лечения во многих регионах яв-ляются неудовлетворительными [1]. Новые техники хирургического лечения -активное тиражирование эндовидеохирургии -не улучшили отдаленные ре-зультаты лечения. В недавно выполненном под кон-тролем Gynecologic Oncology Group (GOG) проспек-

show abstract

The impact of obesity on surgical staging, complications, and survival with uterine cancer: A Gynecologic Oncology Group LAP2 ancillary data study

Cited by 117 publications

References 14 publications

Feasibility and Safety of Laparoscopic Surgery for Obese Korean Women with Endometrial Cancer: Long-Term Results at a Single Institution

Feasibility and Safety of Laparoscopic Surgery for Obese Korean Women with Endometrial Cancer: Long-Term Results at a Single Institution

Perioperative Outcomes in Robotic-Assisted Versus Conventional Laparoscopic Treatment of Endometrial Cancer

Aromatase inhibitors of the third generation in endocrine therapy of breast cancer and endometrial cancer: the successes and failures of the combination therapy

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