The Impact of Obesity on Pentraxin 3 and Inflammatory Milieu to Acute Aerobic Exercise

Exercise reduced pentraxin 3 levels produced by endotoxin-stimulated human peripheral blood mononuclear cells in obese individuals

“…Nonetheless, our important findings demonstrate that LPS-induced PTX3 production levels from PBMCs at rest, which are similar in obese and normal-weight individuals, do not appear to contribute to the reduced plasma PTX3 levels that our laboratory has previously observed in obesity. 8 These results also indicate that the capacity of PBMCs to produce PTX3 ex vivo as a counter-regulatory protein following inflammatory challenge is intact in obesity. Furthermore, in contrast to our laboratory’s previous finding that acute exercise slightly increases plasma PTX3 levels in both groups, 8 the LPS-stimulated ex vivo production of PTX3 in both obese and normal-weight groups was decreased immediately following acute aerobic exercise.…”

“…Finally, data on plasma PTX3 concentrations from our current subjects (9 obese and 9 normal-weight only) have been previously published. 8 Thus, this study also examined the relationship of plasma and LPS-stimulated ex vivo production of PTX3 with LPS-stimulated ex vivo IL-6, IL-10, and TNF-a production at rest and in response to acute exercise. All data are presented as means AE SEM unless otherwise stated with statistical significance being defined as a P value 0.05.…”

“…1,4,5 During obesity, expression of PTX3 mRNA is increased in visceral adipose tissue. 1,6 To the contrary, circulating concentrations of PTX3 are lower in obese compared to normal-weight individuals, 7,8 indicating that plasma PTX3 levels are distinct from those produced at local inflammatory sites in obesity.…”

“…20 We have recently demonstrated that acute aerobic exercise enhances plasma PTX3 levels in obese and normal-weight subjects, but obese PTX3 levels are still less than 50% of the normal-weight subject levels. 8 Therefore, the purpose of this study was to determine whether or not obesity would reduce the capacity of PBMCs to produce PTX3 in response to ex vivo stimulation with LPS, and if acute aerobic exercise would enhance this PTX3 production capacity. In addition, the inter-relationships of LPS-induced PTX3 with the inflammatory cytokines (IL-6, IL-10 and TNF-a) were examined.…”

Effects of eccentric exercise-induced delayed onset muscle soreness on endoplasmic reticulum stress-related markers

“…It is reported that increased cardiorespiratory fitness elicits anti-inflammatory and cardio-protective effects, which reduce the risk of cardiovascular disease [25]. It is stated in the literature that basal PTX3 level, a marker of inflammation, is low in individuals with obesity and metabolic syndrome [26], whereas it is high in trained athletes [27] and that PTX3 levels go up with the chronic [25] effect of exercise given to obese or healthy individuals, which all support this idea.…”