The impact of obesity on cardiovascular disease mortality in the District Sumperk, Czech Republic

Máchová, L; Čížek, Luděk; Koutná, Jiřina; Beska, F; Janoutová, Gabriela; Lorenc, J; Janout, V

doi:10.1007/s00038-007-6073-2

Cited by 3 publications

(1 citation statement)

References 11 publications

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“…Sabe-se que, para indivíduos obesos, o risco de morte por doenças cardiovasculares é maior quando comparado a indivíduos eutróficos (MÁCHOVÁ et al, 2007).…”

Section: Consequências Da Obesidade Na Adolescênciaunclassified

Relação da atividade física com estado nutricional e marcadores bioquímicos em adolescentes de escolas públicas de Piracicaba, São Paulo

Romero

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Introduction-Obesity, dyslipidemia and high levels of insulin are important risk factors to different non transferable chronic diseases. Nowadays the physical activity has been indicated to prevent and treat these risk factors from the childhood and adolescence. Objectives-To study the possible association among physical activity, nutritional state and biochemical markers in adolescents enrolled in public schools in Piracicaba, São Paulo. Methods-Through questionnaires were collected information about physical activity and food intake. Were also performed anthropometric measurements and blood sampling for biochemical analyzes. The sample consisted in 454 adolescents of both genders, enrolled in the 5 th grade in the elementary school education of the public school in Piracicaba. Descriptive analysis were performed and it was used U de Mann Whitney for comparisons between genders. Patterns of physical activity were defined from the principal component analysis. To investigate the association between physical activity and the dependent variables were used multiple logistic regression models. Results-It was observed high prevalence of insufficiently active individuals, overweight and dyslipidemia. It was found an association between physical activity level and the desirable value of HDL-c (high density lipoproteins) (OR:2,25; 95% IC:1,04-4,87) and between the physical activity patterns of sedentary and overweight (OR:1,25; 95% IC:1,04-1,50). Conclusion-While the highest level of physical activity increases the likelihood of adolescents have adequate levels of HDL, sedentary behavior increases the chance of the adolescent presenting overweight. The physical activity patterns identified by principal components analysis can contribute to determine feasible strategies for prevention and treatment of population obesity. Considering the benefits of physical activity and the high prevalence of overweight and dyslipidemia, we clearly realize the need for public health programs that encourage regular physical activity among children in Piracicaba.

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“…Sabe-se que, para indivíduos obesos, o risco de morte por doenças cardiovasculares é maior quando comparado a indivíduos eutróficos (MÁCHOVÁ et al, 2007).…”

Section: Consequências Da Obesidade Na Adolescênciaunclassified

Relação da atividade física com estado nutricional e marcadores bioquímicos em adolescentes de escolas públicas de Piracicaba, São Paulo

Romero

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Social change and Cultural diversity – current and future topics in IJPH

Abel¹,

Kohlmann²

2007

Int J Public Health

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Polygala tenuifolia extract inhibits lipid accumulation in 3T3-L1 adipocytes and high-fat diet–induced obese mouse model and affects hepatic transcriptome and gut microbiota profiles

Wang

Yen

Cheng

et al. 2017

Food & Nutrition Research

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Obesity, the excessive accumulation of lipids in the body, is closely associated with many prevalent human disorders. Continued efforts to identify plant extracts that exhibit anti-obesity effects have drawn much attention. This study investigated whether a Polygala tenuifolia extract (PTE) possesses anti-obesity activity and how PTE may affect liver gene expression and gut microbiota. We used 3T3-L1 adipocytes and a high-fat diet–induced obese mouse model to determine the effects of PTE on lipid accumulation. Next-generation sequencing analysis of liver gene expression and gut microbiota profiles following PTE treatment were conducted to elucidate possible mechanisms. We found that treatment of fully differentiated 3T3-L1 adipocytes with PTE inhibited lipid accumulation in the cells through reducing lipid formation and triglyceride content and by increasing lipase activity. No cytotoxicity was observed from the PTE treatment. After 5 weeks of treatment with PTE, the increased body weight, elevated serum triglyceride content, and liver steatosis in the high-fat diet–induced obese mice were each reduced. Liver transcriptomic analysis revealed that expression of genes involved in lipid and cholesterol metabolism was significantly altered. The low-grade chronic inflammation of obesity caused by a high-fat diet was also decreased after PTE treatment. In addition, treatment with PTE improved the relatively low Bacteroidetes/Firmicutes ratio in the gut of high-fat diet–fed mice through enrichment of the Proteobacteria population and reduction of the Deferribacteres population. In conclusion, treatment with PTE inhibited lipid accumulation by inducing the expression of the master transcription factor PPARα, attenuated the low-grade chronic inflammation of obesity, and also altered gut microbiota profiles. These results indicate that PTE has the potential to be developed into an anti-obesity food supplement and therapy. Abbreviations: Abcg5: ATP-binding cassette subfamily G member 5; ALT: alanine aminotransferase; AMPK: adenosine monophosphate-activated protein kinase; AST: aspartate aminotransferase; B/F: Bacteroidetes to Firmicutes [ratio]; C/EBPα: CCAAT/enhancer-binding protein alpha; CR: creatinine; Cyp51: cytochrome P450 family 51; DMEM: Dulbecco’s modified Eagle’s medium; Fabp5: fatty acid-binding protein 5; FBS: fetal bovine serum; Fdps: farnesyl diphosphate synthase; Glc: Glucose; HFD: high-fat diet; GO: gene ontology; HPRT: hypoxanthine guanine phosphoribosyl transferase; IBMS: 3-isobutyl-1-methylxanthine; Idi1: isopentenyl-diphosphate delta isomerase 1; IL-1β: interleukin-1-beta; Lpin1: phosphatidic acid phosphohydrolase; LPS: lipopolysaccharide; Mvd: mevalonate diphosphate decarboxylase; ND: normal diet; OTU: operational taxonomic units; Pcsk9: proprotein convertase subtilisin/kexin 9; Pctp: phosphatidylcholine transfer protein; PPARα: peroxisome proliferator-activated receptor alpha; PPARγ: peroxisome proliferator-activated receptor gamma; PTE: Polygala tenuifolia extract; Saa1: serum amyloid A1; SD: ...

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The impact of obesity on cardiovascular disease mortality in the District Sumperk, Czech Republic

Abstract: An increased risk of cardiovascular mortality following exposure to obesity was observed. Younger age groups seem to be the important target population for preventive programmes focusing on treatment of obesity.

Cited by 3 publications

References 11 publications

Relação da atividade física com estado nutricional e marcadores bioquímicos em adolescentes de escolas públicas de Piracicaba, São Paulo

Relação da atividade física com estado nutricional e marcadores bioquímicos em adolescentes de escolas públicas de Piracicaba, São Paulo

Social change and Cultural diversity – current and future topics in IJPH

Polygala tenuifolia extract inhibits lipid accumulation in 3T3-L1 adipocytes and high-fat diet–induced obese mouse model and affects hepatic transcriptome and gut microbiota profiles

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