The impact of non-toxic blue light (453 nm) on cellular antioxidative capacity, TGF-β1 signaling, and myofibrogenesis of human skin fibroblasts

Suschek, Christoph V.; Prost, Max; Grotheer, Vera; Schiefer, Jennifer Lynn; Demir, Erhan; Fuchs, Paul Christian; Windolf, Joachim; Stürmer, Ewa K.; Opländer, Christian

doi:10.1016/j.jphotobiol.2020.111952

Cited by 21 publications

(15 citation statements)

References 42 publications

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“…1,2,25,43 Finally, BL has been shown to activate antioxidative capacities of human skin fibroblasts, which may mediate further antinociceptive effects. 29,39 However, the optimal extent and time scale required for BL to affect nociception, especially in patients with chronic pain, requires further investigation.…”

Section: Potential Mechanisms Of Blue-light Treatmentmentioning

confidence: 99%

Blue-light treatment reduces spontaneous and evoked pain in a human experimental pain model

Reuss¹,

Groos

Schöll

et al. 2021

PR9

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Introduction: Chronic pain is a frequent severe disease and often associated with anxiety, depression, insomnia, disability, and reduced quality of life. This maladaptive condition is further characterized by sensory loss, hyperalgesia, and allodynia. Blue light has been hypothesized to modulate sensory neurons and thereby influence nociception.Objectives: Here, we compared the effects of blue light vs red light and thermal control on pain sensation in a human experimental pain model. Methods: Pain, hyperalgesia, and allodynia were induced in 30 healthy volunteers through high-density transcutaneous electrical stimulation. Subsequently, blue light, red light, or thermal control treatment was applied in a cross-over design. The nonvisual effects of the respective light treatments were examined using a well-established quantitative sensory testing protocol. Somatosensory parameters as well as pain intensity and quality were scored. Results: Blue light substantially reduced spontaneous pain as assessed by numeric rating scale pain scoring. Similarly, pain quality was significantly altered as assessed by the German counterpart of the McGill Pain Questionnaire. Furthermore, blue light showed antihyperalgesic, antiallodynic, and antihypesthesic effects in contrast to red light or thermal control treatment. Conclusion: Blue-light phototherapy ameliorates pain intensity and quality in a human experimental pain model and reveals antihyperalgesic, antiallodynic, and antihypesthesic effects. Therefore, blue-light phototherapy may be a novel approach to treat pain in multiple conditions.

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Section: Potential Mechanisms Of Blue-light Treatmentmentioning

confidence: 99%

Blue-light treatment reduces spontaneous and evoked pain in a human experimental pain model

Reuss¹,

Groos

Schöll

et al. 2021

PR9

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“…Despite evidence that blue light has harmful effects on the skin, it may conversely also have beneficial effects such as antiproliferative and anti‐inflammatory properties 19,21,22 . Moreover, phototherapy with blue light has been investigated as a potential treatment for psoriasis and atopic dermatitis lesions, with positive clinical outcomes 21 .…”

Section: Introductionmentioning

confidence: 99%

“…2,13,15,18,20 Despite evidence that blue light has harmful effects on the skin, it may conversely also have beneficial effects such as antiproliferative and anti-inflammatory properties. 19,21,22 Moreover, phototherapy with blue light has been investigated as a potential treatment for psoriasis and atopic dermatitis lesions, with positive clinical outcomes. 21 The overall physiological effect of blue light on the skin therefore depends on the underlying condition of the skin, as well as on the duration, dose and irradiance of exposure.…”

Section: Introductionmentioning

confidence: 99%

Formulation of a new broad‐spectrum UVB + UVA and blue light SPF50⁺ sunscreen containing Phenylene Bis‐Diphenyltriazine (TriAsorB), an innovative sun filter with unique optical properties

Bacqueville

Jacques

Lapalud

et al. 2022

Acad Dermatol Venereol

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Accumulating evidence from numerous comprehensive studies has demonstrated that blue light, in particular high‐energy visible light, can exert a range of harmful effects on skin cells. These forms of radiation are now known to be able to trigger oxidation reactions, DNA damage, erythema and pigmentary changes, and may also be associated with photoaging. Sunscreens protecting the skin from only ultraviolet (UV)‐B and UVA rays can therefore no longer be regarded as sufficient to help prevent skin damage from sunlight, and products containing filters that can provide broad‐spectrum photoprotection are required. To meet this need, a new sunscreen formulation that provides photoprotection against solar radiation with wavelengths ranging from UV to visible light has been developed, using an innovative organic sun filter with unique optical properties: phenylene bis diphenyltriazine (TriAsorB™). This article outlines the development and characteristics of this innovative filter and describes new key results from studies performed to assess the effectiveness and safety of the filter and the new sunscreen product. The studies conducted so far demonstrate that the filter has a good human and environmental safety profile. In addition, the sunscreen, which contains TriAsorB in combination with three other UV filters to offer broad‐spectrum sun protection with a high sun protection factor (SPF50+), appears to effectively prevent multiple forms of cellular photodamage, in particular blue light‐induced oxidatively generated DNA lesions. Overall, the available data indicate that regular use of the TriAsorB‐containing sunscreen could help prevent solar radiation‐induced skin damage and the development of signs of premature skin aging, as well as photodermatoses caused or exacerbated by visible light.

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“…Other groups reported positive effects in the healing of chronic wounds [ 26 , 41 ]. Depending on light parameters, blue light also reduced proliferation of skin cells, aiding in the treatment of hypertrophic scars [ 42 , 43 ]. Thus, we were interested in using blue light with a wavelength of 475 nm and an intensity of 50 mW/cm 2 on Gram-positive as well as -negative bacterial strains to test the antimicrobial potential.…”

Section: Discussionmentioning

confidence: 99%

Resistance of Bacteria toward 475 nm Blue Light Exposure and the Possible Role of the SOS Response

Metzger

Hacobian

Karner

et al. 2022

Life

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The increase in antibiotic resistance represents a major global challenge for our health systems and calls for alternative treatment options, such as antimicrobial light-based therapies. Blue light has shown promising results regarding the inactivation of a variety of microorganisms; however, most often, antimicrobial blue light (aBL) therapy is performed using wavelengths close to the UV range. Here we investigated whether inactivation was possible using blue light with a wavelength of 475 nm. Both Gram-positive and -negative bacterial strains were treated with blue light with fluences of 7.5–45 J/cm2. Interestingly, only some bacterial strains were susceptible to 475 nm blue light, which was associated with the lack of RecA, i.e., a fully functional DNA repair mechanism. We demonstrated that the insertion of the gene recA reduced the susceptibility of otherwise responsive bacterial strains, indicating a protective mechanism conveyed by the bacterial SOS response. However, mitigating this pathway via three known RecA inhibiting molecules (ZnAc, curcumin, and Fe(III)-PcTs) did not result in an increase in bactericidal action. Nonetheless, creating synergistic effects by combining a multitarget therapy, such as aBL, with an RecA targeting treatment could be a promising strategy to overcome the dilemma of antibiotic resistance in the future.

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The impact of non-toxic blue light (453 nm) on cellular antioxidative capacity, TGF-β1 signaling, and myofibrogenesis of human skin fibroblasts

Cited by 21 publications

References 42 publications

Blue-light treatment reduces spontaneous and evoked pain in a human experimental pain model

Blue-light treatment reduces spontaneous and evoked pain in a human experimental pain model

Formulation of a new broad‐spectrum UVB + UVA and blue light SPF50⁺ sunscreen containing Phenylene Bis‐Diphenyltriazine (TriAsorB), an innovative sun filter with unique optical properties

Resistance of Bacteria toward 475 nm Blue Light Exposure and the Possible Role of the SOS Response

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The impact of non-toxic blue light (453 nm) on cellular antioxidative capacity, TGF-β1 signaling, and myofibrogenesis of human skin fibroblasts

Cited by 21 publications

References 42 publications

Blue-light treatment reduces spontaneous and evoked pain in a human experimental pain model

Blue-light treatment reduces spontaneous and evoked pain in a human experimental pain model

Formulation of a new broad‐spectrum UVB + UVA and blue light SPF50+ sunscreen containing Phenylene Bis‐Diphenyltriazine (TriAsorB), an innovative sun filter with unique optical properties

Resistance of Bacteria toward 475 nm Blue Light Exposure and the Possible Role of the SOS Response

Contact Info

Product

Resources

About

Formulation of a new broad‐spectrum UVB + UVA and blue light SPF50⁺ sunscreen containing Phenylene Bis‐Diphenyltriazine (TriAsorB), an innovative sun filter with unique optical properties