The Impact of Nitazoxanide Loaded on Solid Lipid Nanoparticles on Experimental Trichinellosis

Hassan, Mohamed A.; El-Rahman, Eman Abd; El-Hamed, Enas Abd; Fattah, Ashraf; Harb, Ola A.; Mohamed, Samar; Sarhan, Mohamed

doi:10.21608/zumj.2019.16531.1480

Cited by 5 publications

(3 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the present work, the levels of ALT and AST were significantly elevated in the infected groups compared to the non-infected control group. These findings agreed with Hassan et al (2021a), Basyoni and Elsabah (2013), and Swilam et al . (2022), who reported elevation in serum ALT and AST in mice infected with T. spiralis due to liver damage by migrating larvae.…”

Section: Discussionsupporting

confidence: 93%

Impact of resveratrol and zinc on biomarkers of oxidative stress induced by Trichinella spiralis infection

Salama,

Alabiad,

Saleh

2023

J. Helminthol.

View full text Add to dashboard Cite

Trichinellosis is a re-emerging worldwide foodborne zoonosis. Oxidative stress is one of the most common detrimental effects caused by trichinellosis. In addition, Trichinella infection poses an infinite and major challenge to the host’s immune system. Resistance and side effects limit the efficiency of the existing anti-trichinella medication. Given that concern, this work aimed to investigate the anti-helminthic, antioxidant, anti-inflammatory and immunomodulatory effects of resveratrol and zinc during both phases of Trichinella spiralis infection. Sixty-four Swiss albino mice were divided into four equal groups: non-infected control, infected control, infected and treated with resveratrol, and infected and treated with zinc. Animals were sacrificed on the 7th and 35th days post-infection for intestinal and muscular phase assessments. Drug efficacy was assessed by biochemical, parasitological, histopathological, immunological, and immunohistochemical assays. Resveratrol and zinc can be promising antiparasitic, antioxidant, anti-inflammatory, and immunomodulatory agents, as evidenced by the significant decrease in parasite burden, the significant improvement of liver and kidney function parameters, the increase in total antioxidant capacity (TAC), the reduction of malondialdehyde (MDA) level, the increase in nuclear factor (erythroid-derived 2)-like-2 factor expression, and the improvement in histopathological findings. Moreover, both drugs enhanced the immune system and restored the disturbed immune balance by increasing the interleukin 12 (IL-12) level. In conclusion, resveratrol and zinc provide protection for the host against oxidative harm and the detrimental effects produced by the host’s defense response during Trichinella spiralis infection, making them promising natural alternatives for the treatment of trichinellosis.

show abstract

Section: Discussionsupporting

confidence: 93%

Impact of resveratrol and zinc on biomarkers of oxidative stress induced by Trichinella spiralis infection

Salama,

Alabiad,

Saleh

2023

J. Helminthol.

View full text Add to dashboard Cite

show abstract

“…As a result, twelve oxygen anions coordinate the A-cation, whereas the B-cation is found in the octahedral interstices. The corners of the B octahedra joined to form a three-dimensional framework (Hassan, 2016;Jeon et al, 2015).…”

Section: Theorymentioning

confidence: 99%

Comparison between different solar cells based on perovskite types

Elblbeisi¹,

Shabat²

2023

IUJAS

View full text Add to dashboard Cite

Perovskite solar cells (PSCs) are getting popular as promising photovoltaic technology due to their high efficiency and economical manufacturing costs. PSCs' effectiveness and stability have continuously improved in recent years, and research into minimizing lead leakage and creating environmentally acceptable lead-free perovskites is advancing the commercialization of PSCs step by step. The goal of this paper is to design a solar cell model based on getting higher light transmission and lower light reflection. Three-layer solar cell structure containing perovskite, titanium dioxide, and metal Nano layer sandwich between a silicon substrate and glass cover. The Maple 17 software is used to create the numerical results for the Transfer matrix, which determines the transmission and reflection of the incident light for various physical parameters of the structure. The results showed that the cell with aluminum cell has an excellent transmittance for a wide range of incident angles, perovskite thickness, and effective layer thickness. The short circuit current density reaches the most significant value at (𝛼 = 0), and it has zero value for parallel incidents. The cell of CH3NH3PbI3perovskite type and the aluminum metal nanolayer has the highest current density and a non-zero value for a wide range of incident angles.

show abstract

“…Previous studies have loaded NTZ within liposomes and solid lipid nanoparticles [41][42][43]. Herein, NTZ was successfully loaded within NLCs.…”

Section: Plos Neglected Tropical Diseasesmentioning

confidence: 99%

Potent efficiency of the novel nitazoxanide-loaded nanostructured lipid carriers against experimental cyclosporiasis

Hagras,

Makled,

Sheta

et al. 2023

PLoS Negl Trop Dis

View full text Add to dashboard Cite

Cyclosporiasis is a ubiquitous infection caused by an obligate intracellular protozoan parasite known as Cyclospora cayetanensis (C. cayetanensis). The disease is characterized by severe diarrhea which may be regrettably fatal in immunosuppressed patients. The commercially available treatment options have either severe side effects or low efficiency. In the present study, the novel formula of nitazoxanide (NTZ)-loaded nanostructured lipid carriers (NLCs) was assessed for the first time for C. cayetanensis treatment in both immunocompetent and immunosuppressed mice in comparison to commercially available drugs (trimethoprim-sulfamethoxazole (TMP-SMX) and NTZ). Swiss Albino mice were orally infected by 104 sporulated oocysts. The experimental groups were treated with the gold standard TMP-SMX, NTZ, blank NLCs and NTZ-loaded NLCs. The results demonstrated that NTZ-loaded NLCs represented the highest significant parasite percent reduction of (>98% reduction) in both immunocompetent and immunosuppressed mice designating successful tissue penetration and avoiding recurrence of infection at the end of the study. Oocysts treated with NTZ-loaded NLCs demonstrated the most mutilated rapturing morphology via scanning electron microscope examination as well as representing the most profound improvement of the histopathological picture. In conclusion, NTZ-loaded NLCs exhibited the uppermost efficacy in the treatment of cyclosporiasis. The safe nature and the anti-parasitic effect of the novel formulation encourage its use as a powerful treatment for human cyclosporiasis.

show abstract

The Impact of Nitazoxanide Loaded on Solid Lipid Nanoparticles on Experimental Trichinellosis

Cited by 5 publications

References 22 publications

Impact of resveratrol and zinc on biomarkers of oxidative stress induced by Trichinella spiralis infection

Impact of resveratrol and zinc on biomarkers of oxidative stress induced by Trichinella spiralis infection

Comparison between different solar cells based on perovskite types

Potent efficiency of the novel nitazoxanide-loaded nanostructured lipid carriers against experimental cyclosporiasis

Contact Info

Product

Resources

About