The impact of neoadjuvant therapy for gastroesophageal adenocarcinoma on postoperative morbidity and mortality

Abstract

Despite having more advanced disease and undergoing higher-risk surgical procedures, patients with adenocarcinomas of the stomach or GEJ who receive NAT prior to surgery are no more likely to suffer postoperative complications than patients treated with a surgery-first approach. J. Surg. Oncol. 2016;113:560-564. © 2016 Wiley Periodicals, Inc.

Comparison of neoadjuvant chemotherapy followed by surgery vs. surgery alone for locally advanced gastric cancer: a meta-analysis

“…Data from 14 studies, which reported total complications after, were extracted, including 1085 patients in the NACS group and 1576 in the SA group. [22,23,[25][26][27]29,[33][34][35][36][37][38][39][40] A moderate heterogeneity was detected (P = 0.120, ). [10,22,23,25,27,29,30,[32][33][34][35][37][38][39][40] A fixed-effects model was used as a result of undetected heterogeneity (P = 0.780, I 2 = 0%).…”

“…[22,23,[25][26][27]29,[33][34][35][36][37][38][39][40] A moderate heterogeneity was detected (P = 0.120, ). [10,22,23,25,27,29,30,[32][33][34][35][37][38][39][40] A fixed-effects model was used as a result of undetected heterogeneity (P = 0.780, I 2 = 0%). The funnel plot suggested there was no publication bias (Egger test, t = À1.01, P = 0.34; Begg test, z c = À0.45, P = 0.66) [Supplementary Figure 1F, http://links.lww.com/CM9/A641].…”

“…The basic features of the 20 studies involved are shown in Table 1, six for RCT and 14 for RCNT studies, with 3362 GC patients, including 1420 in the NACS group and 1942 in the SA group. [10,[22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39] All studies were published between January 2000 and January 2021. More specifically, Schuhmacher et al [32] and Fuentes et al [25] incorporated patients with gastroesophageal junction cancer, and the surgical procedure also included D1 dissection.…”

“…[10,[22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39] All studies were published between January 2000 and January 2021. More specifically, Schuhmacher et al [32] and Fuentes et al [25] incorporated patients with gastroesophageal junction cancer, and the surgical procedure also included D1 dissection. Biffi et al [23] performed D3 dissection in patients enrolled in the study.…”

“…Ten studies reported on the classification of post-operative complications, [23,25,27,30,[33][34][35][38][39][40] which were divided into five grades using the Clavien-Dindo system. [41] Grades II to IV of post-operative complications were analyzed by a fixed-effects model because of undetected heterogeneity, and the results showed that there was no statistically significant difference between the NACS and SA groups in any degree of complications.…”