The impact of multi-walled carbon nanotubes with different amount of metallic impurities on immunometabolic parameters in healthy volunteers

Виткина, Т. И.; Yankova, Vera; Gvozdenko, T. A.; Кузнецов, В. Л.; Krasnikov, Dmitry V.; Nazarenko, A. V.; Чайка, Владимир; Smagin, S. V.; Tsatsakis, Aristidis; Engin, Ayşe Başak; Karakitsios, Spyros; Sarigiannis, D; Golokhvast, Kirill S.

doi:10.1016/j.fct.2015.11.023

Cited by 43 publications

(19 citation statements)

References 63 publications

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“…Of the information available mussel hemocytes, exposed in vitro and in vivo for 24 h, have been shown to display sublethal responses to carbon black and fullerene (0.01-1 mg.L −1 ) with little to no effects when exposed to a carbon nanotube (0.01-1 mg.L −1 ) (Canesi et al, 2010(Canesi et al, , 2008bMoore et al, 2009). Previous studies in human toxicology have shown induction of oxidative stress and inflammation when cells, IL-8, A549 and HaCaT, were exposed to multi-walled carbon nanotubes at 1 mg/L and 25 mg.L −1 for 24 h (Vitkina et al, 2016;Ye et al, 2009).When analyzing the in vivo responses, the gene expression had little significant effects (which may be attributed to the small sample sizes) with all three CNFs and little clear pattern is evident with the CNFs. There is a however a notable trend for GATam to have higher fold expressions which could suggest more adverse effects may occur with this CNF.…”

Section: Gene Expressionmentioning

confidence: 95%

Investigating a transcriptomic approach on marine mussel hemocytes exposed to carbon nanofibers: An in vitro/in vivo comparison

et al. 2019

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Manufactured nanomaterials are an ideal test case of the precautionary principle due to their novelty and potential environmental release. In the context of regulation, it is difficult to implement for manufactured nanomaterials as current testing paradigms identify risk late into the production process, slowing down innovation and increasing costs. One proposed concept, namely safe(r)-by-design, is to incorporate risk and hazard assessment into the design process of novel manufactured nanomaterials by identifying risks early. When investigating the manufacturing process for nanomaterials, differences between products will be very similar along key physicochemical properties and biological endpoints at the individual level may not be sensitive enough to detect differences whereas lower levels of biological organization may be able to detect these variations. In this sense, the present study used a transcriptomic approach on Mytilus edulis hemocytes following an in vitro and in vivo exposure to three carbon nanofibers created using different production methods. Integrative modeling was used to identify if gene expression could be in linked to physicochemical features. The results suggested that gene expression was more strongly associated with the carbon structure of the nanofibers than chemical purity. With respect to the in vitro/in vivo relationship, results suggested an inverse relationship in how the physicochemical impact gene expression.

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Section: Gene Expressionmentioning

confidence: 95%

Investigating a transcriptomic approach on marine mussel hemocytes exposed to carbon nanofibers: An in vitro/in vivo comparison

et al. 2019

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“…The length of carbon nanotubes was hundreds of times larger than diameter and in water suspension, the particles could cohere into the spheres up to tens of micrometers in diameter. The toxicity of these NP samples has been previously evaluated on mice [21], rats [22,23], human cell lines [24], and microalgae Heterosigma akashiwo [16].…”

Section: Nanoparticlesmentioning

confidence: 99%

Comparison of the Level and Mechanisms of Toxicity of Carbon Nanotubes, Carbon Nanofibers, and Silicon Nanotubes in Bioassay with Four Marine Microalgae

Pikula¹,

Чайка²,

Zakharenko³

et al. 2020

Preprint

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Nanoparticles (NPs) have various applications in medicine, cosmetics, optics, catalysis, environmental purification, and other areas nowadays. With an increasing annual production of NPs, the risks of their harmful influence to the environment and human health is rising. Currently, our knowledge about the mechanisms of interaction between NPs and living organisms is limited. Additionally, poor understanding of how physical and chemical characteristic and different conditions influence the toxicity of NPs restrict our attempts to develop the standards and regulations which might allow us to maintain the safe living conditions. The marine species and their habitat environment are under continuous stress due to anthropogenic activities which result in the appearance of NPs in the aquatic environment. Our study aimed to evaluate and compare biochemical effects caused by the influence of different types of carbon nanotubes, carbon nanofibers, and silica nanotubes on four marine microalgae species. We have evaluated the changes in growth-rate, esterase activity, membrane polarization, and size changes of microalgae cells using flow cytometry method. Our results demonstrated that toxic effects caused by the carbon nanotubes strongly correlated with the content of heavy metal impurities in the NPs. More hydrophobic carbon NPs with less ordered structure had a higher impact on the red microalgae P. purpureum because of higher adherence between the particles and mucous covering of the algae; silica NPs caused significant inhibition of microalgae growth-rate predominantly produced by mechanical influence.

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“…The introduction of UFP into a cell leads to disruption of its functioning and energy metabolism. The impossibility of the rapid elimination of micro-sized SPM leads to their chronic accumulation in organs and tissues, which result in long-term negative effect [9]. Adverse climatic factors and meteorological conditions can aggravate the effect of pollution particles [10].…”

Section: Introductionmentioning

confidence: 99%

Assessment of air pollution by small-sized suspended particulate matter in urbanized territories with various technogenic load (on the example of Vladivostok, Russia)

Barskova¹,

Виткина²,

Gvozdenko³

et al. 2019

Russ Open Med J

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The aim of the study was to estimate the pollution of the atmospheric surface layer by suspended particulate matter (SPM) in two districts of Vladivostok with different levels of technogenic load. Material and Methods -The air samples were taken in the "breathing zone" by an electric aspirator simultaneously to the liquid absorbing medium and on the filter, laser granulometry was used to assess the dispersion, and the mass concentration of the SPM fractions was calculated.Results -Ultrafine particles were detected in the air in the area with a high man-made load. Air levels of particles with an aerodynamic diameter of 0.1-1 μm, 1-2.5 μm (respirable fraction) and 2.5-10 μm (tracheobronchial fraction) were 5, 2.7 and 3.3 times higher, respectively, in the area with a high man-made load in comparison with the area with insignificant technogenic load. Conclusion -Particles with an aerodynamic diameter less than 10 μm, which have the most pathogenic effect, prevail in the air in the urbanized area with a high technogenic load. The predominance of SPM fractions with an aerodynamic diameter more than 10 μm is a characteristic feature of air pollution in the territory with a low man-made load.

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The impact of multi-walled carbon nanotubes with different amount of metallic impurities on immunometabolic parameters in healthy volunteers

Cited by 43 publications

References 63 publications

Investigating a transcriptomic approach on marine mussel hemocytes exposed to carbon nanofibers: An in vitro/in vivo comparison

Investigating a transcriptomic approach on marine mussel hemocytes exposed to carbon nanofibers: An in vitro/in vivo comparison

Comparison of the Level and Mechanisms of Toxicity of Carbon Nanotubes, Carbon Nanofibers, and Silicon Nanotubes in Bioassay with Four Marine Microalgae

Assessment of air pollution by small-sized suspended particulate matter in urbanized territories with various technogenic load (on the example of Vladivostok, Russia)

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