The Impact of Mosaic Embryos on Procreative Liberty and Procreative Responsibility: Time to Put Innovative Technology on “Pause”

Takahashi, Shizuko; Patrizio, Pasquale

doi:10.1007/s40778-019-00164-z

Cited by 4 publications

(7 citation statements)

References 51 publications

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“…The term "disability" was mentioned in 12 abstracts and "deafness" in 8. However, other articles discussed cases of misdiagnosis [59], or situations in which only abnormal embryos are available to implant [60,61]. These situations became more frequently discussed with the emerging complexities stemming from the extra information new procedures yield, which may generate dilemmas regarding the *The groups A2, A3 A4, B5, and C4 cover questions of semi-clinical character that were captured in our search for ELSI literature.…”

Section: Cluster B (Yellow)-reproductive Autonomy Eugenics and Procre...mentioning

confidence: 99%

“…The genetic basis of complex physical or cognitive traits is intricate and not easily selected. Furthermore, there are limits to the number of available eggs and embryos for complex selections and the production of artificial gametes remains uncertain and may cause epigenetic complications, as raised by some articles from group B2 and B4 [61,83,84]. If any of these radical scenarios become clinically relevant in the future, they would more likely involve germline genome editing by CRISPR rather than PGT [82].…”

Section: Issues Receiving Ample Elsi Attention But Are Not Clinically...mentioning

confidence: 99%

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Mapping ethical, legal, and social implications (ELSI) of preimplantation genetic testing (PGT)

Alon,

Bussod,

Ravitsky

2024

J Assist Reprod Genet

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Purpose Preimplantation Genetic Testing (PGT) has attracted considerable ethical, legal, and social scrutiny, but academic debate often fails to reflect clinical realities. Methods Addressing this disconnect, a review of 506 articles from 1999 to 2019 across humanities and social sciences was conducted to synthesize the Ethical, Legal, and Social Implications (ELSI) of PGT. This review mined PubMed, WoS, and Scopus databases, using both MeSH terms and keywords to map out the research terrain. Results The findings reveal a tenfold increase in global research output on PGT’s ELSI from 1999 to 2019, signifying rising interest and concern. Despite heightened theoretical discourse on selecting “optimal” offspring, such practices were scarcely reported in clinical environments. Conversely, critical issues like PGT funding and familial impacts remain underexplored. Notably, 86% of the ELSI literature originates from just 12 countries, pointing to a research concentration. Conclusion This review underscores an urgent need for ELSI research to align more closely with clinical practice, promoting collaborations among ethicists, clinicians, policymakers, and economists. Such efforts are essential for grounding debates in practical relevance, ultimately steering PGT towards ethical integrity, societal acceptance, and equitable access, aiming to harmonize PGT research with real-world clinical concerns, enhancing the relevance and impact of future ethical discussions.

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Section: Cluster B (Yellow)-reproductive Autonomy Eugenics and Procre...mentioning

confidence: 99%

Section: Issues Receiving Ample Elsi Attention But Are Not Clinically...mentioning

confidence: 99%

Mapping ethical, legal, and social implications (ELSI) of preimplantation genetic testing (PGT)

Alon,

Bussod,

Ravitsky

2024

J Assist Reprod Genet

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“…There are many potential health risks and risks to development from unintended changes to DNA as a result of the editing process (most importantly, risks from off-target edits resulting in unintended mutagenesis and mosaicism) [ 59 , 60 ]. Determining whether unintended effects are pathogenic or inert requires having a better understanding of what abnormalities or mutations in an embryo raise risks to an unacceptable level for transferring an embryo to start a pregnancy (this is also an issue in screening embryos during PGD) [ 61 , 62 ]. Research into editing of human embryos has also generated some surprises; for example, over the role of homology directed repair of double strand breaks in the DNA of embryos [ 63 – 65 ].…”

Section: What Is the Potential Clinical Utility Of Germline Gene Editmentioning

confidence: 99%

Responsible Translational Pathways for Germline Gene Editing?

Cwik

2020

Curr Stem Cell Rep

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Purpose of Review Continued development of gene editing techniques has raised the real possibility of clinical application of germline gene editing. These results, as well as reports of an unethical experiment which resulted in the birth of at least two children from edited embryos in 2018, have highlighted the urgency and importance of ethical issues about translational pathways for editing of human germline cells. Charting responsible translational pathways for germline gene editing requires tackling some significant and complex ethical issues. Recent Findings A literature on development of clinical applications of germline gene editing is emerging, and several key ethical issues are coming into focus as major challenges for responsible translational pathways. Summary Potential clinical utility, clinical justification, and human subjects research for germline gene editing raise outstanding ethical questions. Work on these questions will help provide guidance to researchers and clinicians and direct translational projects toward justifiable applications.

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mentioning

confidence: 99%

“…Preimplantation genetic testing for aneuploidy (PGT-A) is a practice used by in vitro fertilization (IVF) clinics in an effort to maximize implantation and live birth rates ( 1 , 2 ). Current PGT-A technology involves screening a sample of trophectoderm cells in blastocyst embryos for aneuploidy ( 2 ). Recently, next-generation sequencing–based PGT-A has complicated embryo selection due to its ability to identify embryos with chromosomal mosaicism, which contain both euploid and aneuploid cell lines ( 1 ).…”

mentioning

confidence: 99%

Challenges experienced by genetic counselors while they provided counseling about mosaic embryos

Moran,

Flamenbaum,

Myles Reid

et al. 2023

F&S Reports

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The Impact of Mosaic Embryos on Procreative Liberty and Procreative Responsibility: Time to Put Innovative Technology on “Pause”

Cited by 4 publications

References 51 publications

Mapping ethical, legal, and social implications (ELSI) of preimplantation genetic testing (PGT)

Mapping ethical, legal, and social implications (ELSI) of preimplantation genetic testing (PGT)

Responsible Translational Pathways for Germline Gene Editing?

Challenges experienced by genetic counselors while they provided counseling about mosaic embryos

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