The impact of miR-9 in osteosarcoma

Wu, Fengfeng; Jiang, Xuesheng; Wang, Qun; Lü, Qian; He, Feng-xiang; Li, Jianyou; Li, Xiongfeng; Jin, Ming; Xu, Juntao

doi:10.1097/md.0000000000021902

Cited by 5 publications

(2 citation statements)

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“…In HCC, several experimental studies have shown that miR-9-5p can promote the proliferation, invasion, and metastasis of tumor cells by down-regulating the expression of ESR1 [35], Klf4[36], CNNM1 [37], PPARA [38], and so on. In a previous study, high expression of miR-9-5p was associated with a poor prognosis of osteosarcoma [39]. However, patients with high expression of miR-9-5p are reported to have a better prognosis in ovarian cancer [40].…”

Section: Discussionmentioning

confidence: 92%

miR-9-5p Expression is Associated With Vascular Invasion and Prognosis in Hepatocellular Carcinoma

Chen

Zhang

et al. 2021

Preprint

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Hepatocellular carcinoma (HCC) is a common liver malignancy. Early vascular invasion (VI) has been associated with poor prognosis in HCC patients. MicroRNAs (miRNAs) play a significant role in the emergence and development of many tumor types. In this study, we identified miR-9-5p that could predict VI and prognosis in HCC patients based on TCGA database. Further, we explored the possible mechanism of miR-9-5p by target gene prediction, functional enrichment analysis, and protein‑protein interaction analysis. Univariate and multivariate analysis revealed that miR-9-5p was an independent risk factor for HCC. Finally, the nomogram based on miR-9-5p showed a good predictive value of HCC survival. In summary, miR-9-5p is associated with VI in HCC, and higher expression of miR-9-5p indicates poor prognosis in HCC.

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Section: Discussionmentioning

confidence: 92%

miR-9-5p Expression is Associated With Vascular Invasion and Prognosis in Hepatocellular Carcinoma

Chen

Zhang

et al. 2021

Preprint

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“…One of the most studied miRNAs in osteosarcoma is miR-9. Recently, Wu et al published a meta-analysis and concluded that a high expression of miR-9 was associated with poor prognosis [ 73 ]. Patients with highly expressed levels of miR-9 in osteosarcoma tissues present bigger tumor size, more advanced clinical stages, more frequent distant metastasis, and lower survival rates [ 74 ].…”

Section: Possible Applications Of Mirnas In Human Osteosarcomamentioning

confidence: 99%

Role of MicroRNAs in Human Osteosarcoma: Future Perspectives

Llobat

Gourbault²

2021

Biomedicines

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Osteosarcoma (OS) is a rare form of cancer with high death rate but is one of the most frequent forms of bone cancer in children and adolescents. MiRNAs are small endogenous RNAs that regulate gene expression post-transcriptionally. The discovery of miRNAs could allow us to obtain an earlier diagnosis, predict prognosis and chemoresistance, and lead to the discovery of new treatments in different types of tumors, including OS. Despite the fact that there is currently only one clinical trial being carried out on a single miRNA for solid tumors, it is very probable that the number of clinical trials including miRNAs as prognostic and diagnostic biomarkers, as well as potential therapeutic targets, will increase in the near future. This review summarizes the different miRNAs related to OS and their possible therapeutic application.

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