The impact of mild-to-severe hearing loss on the neural dynamics serving verbal working memory processing in children

Heinrichs‐Graham, Elizabeth; Walker, Elizabeth; Eastman, Jacob A.; Frenzel, Michaela R.; Joe, Timothy R.; McCreery, Ryan W.

doi:10.1016/j.nicl.2021.102647

Cited by 11 publications

(20 citation statements)

References 86 publications

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“…Twenty-three youth ages 8 to 15 years old (mean = 11.96 years; SD = 1.93 years; age range: 8.25-15.6 years; 8 females, 2 left-handed) with bilateral mild-to-severe hearing loss (better-ear pure-tone average [BEPTA] of 25-79 dB) who were fitted with two hearing aids were recruited to participate in this study. Of note, a cohort of matched CNH was also recruited to participate, and between-group differences in the neural patterns serving this task are reported elsewhere (Heinrichs-Graham et al 2021). We chose to focus solely on the CHL for this analysis, as we were uniquely interested in the effects of hearing aid use on within-group variability in this population.…”

Section: Participantsmentioning

confidence: 99%

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Amount of Hearing Aid Use Impacts Neural Oscillatory Dynamics Underlying Verbal Working Memory Processing for Children With Hearing Loss

et al. 2021

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Objectives: Children with hearing loss (CHL) may exhibit spoken language delays and may also experience deficits in other cognitive domains including working memory. Consistent hearing aid use (i.e., more than 10 hours per day) ameliorates these language delays; however, the impact of hearing aid intervention on the neural dynamics serving working memory remains unknown. The objective of this study was to examine the association between the amount of hearing aid use and neural oscillatory activity during verbal working memory processing in children with mild-to-severe hearing loss. Design: Twenty-three CHL between 8 and 15 years-old performed a letter-based Sternberg working memory task during magnetoencephalography (MEG). Guardians also completed a questionnaire describing the participants’ daily hearing aid use. Each participant’s MEG data was coregistered to their structural MRI, epoched, and transformed into the time–frequency domain using complex demodulation. Significant oscillatory responses corresponding to working memory encoding and maintenance were independently imaged using beamforming. Finally, these whole-brain source images were correlated with the total number of hours of weekly hearing aid use, controlling for degree of hearing loss. Results: During the encoding period, hearing aid use negatively correlated with alpha-beta oscillatory activity in the bilateral occipital cortices and right precentral gyrus. In the occipital cortices, this relationship suggested that with greater hearing aid use, there was a larger suppression of occipital activity (i.e., more negative relative to baseline). In the precentral gyrus, greater hearing aid use was related to less synchronous activity (i.e., less positive relative to baseline). During the maintenance period, hearing aid use significantly correlated with alpha activity in the right prefrontal cortex, such that with greater hearing aid use, there was less right prefrontal maintenance-related activity (i.e., less positive relative to baseline). Conclusions: This study is the first to investigate the impact of hearing aid use on the neural dynamics that underlie working memory function. These data show robust relationships between the amount of hearing aid use and phase-specific neural patterns during working memory encoding and maintenance after controlling for degree of hearing loss. Furthermore, our data demonstrate that wearing hearing aids for more than ~8.5 hours/day may serve to normalize these neural patterns. This study also demonstrates the potential for neuroimaging to help determine the locus of variability in outcomes in CHL.

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Section: Participantsmentioning

confidence: 99%

“…3B). As described earlier, a comparison of these neural dynamics between these CHL and a matched group of CNH was outside of the scope of this study and can be found elsewhere (Heinrichs-Graham et al 2021).…”

Section: Identification Of Significant Task-related Time-frequency Re...mentioning

confidence: 99%

Amount of Hearing Aid Use Impacts Neural Oscillatory Dynamics Underlying Verbal Working Memory Processing for Children With Hearing Loss

et al. 2021

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“…This sample size was selected based on our prior work showing differences in brain activity between CHH and CNH. 27 , 32 All data collection occurred at the University of Nebraska Medical Center. Exclusionary criteria included any medical illness affecting CNS function, current or previous major neurological or psychiatric disorder, history of head trauma, current substance abuse, and/or the presence of irremovable ferromagnetic material in or on the body (e.g.…”

Section: Methodsmentioning

confidence: 99%

“…imaging) in this study were derived through a two-stage statistical analysis of the sensor-level spectrograms across the entire array of gradiometers (magnetometer data was not analyzed) during the 4 s stimulus presentation window, in line with our previous studies. 27 , 31 , 32 , 39 Each data point in the spectrogram was initially evaluated using a mass univariate approach based on the general linear model. To reduce the risk of false-positive results while maintaining reasonable sensitivity, a two-stage procedure was followed to control for Type 1 error.…”

Section: Methodsmentioning

confidence: 99%

Auditory experience modulates fronto-parietal theta activity serving fluid intelligence

Heinrichs‐Graham

Walker

Taylor

et al. 2022

Brain Communications

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Children who are hard-of-hearing are at risk for developmental language and academic delays compared to children with normal hearing. Some work suggests that high-order cognitive function, including fluid intelligence, may relate to language and academic outcomes in children with hearing loss, but findings in these studies have been mixed and to date there have been no studies of the whole-brain neural dynamics serving fluid intelligence in the context of hearing loss. To this end, this study sought to identify the impact of hearing loss and subsequent hearing aid use on the neural dynamics serving abstract reasoning in children who are hard-of-hearing relative to children with normal hearing using magnetoencephalography. We found significant elevations in occipital and parietal theta activity during early stimulus evaluation in children who are hard of hearing relative to normal-hearing peers. In addition, we found that greater hearing aid use was significantly related to reduced activity throughout the frontoparietal network. Notably, there were no differences in alpha dynamics between groups during later-stage processing, nor did alpha activity correlate with hearing aid use. These cross-sectional data suggest that differences in auditory experience lead to widespread alterations in the neural dynamics serving initial stimulus processing in fluid intelligence in children.

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“…There is a close link between cognitive decline and hearing loss ( Dye and Hauser, 2014 ; Heinrichs-Graham et al, 2021 ). Patients with hearing loss face the risk of delays in multiple cognitive functions, such as working memory and executive function ( Lieu et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Auditory Sensory Gating in Children With Cochlear Implants: A P50-N100-P200 Study

Chen

Huang

et al. 2021

Front. Neurosci.

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Background: While a cochlear implant (CI) can restore access to audibility in deaf children, implanted children may still have difficulty in concentrating. Previous studies have revealed a close relationship between sensory gating and attention. However, whether CI children have deficient auditory sensory gating remains unclear.Methods: To address this issue, we measured the event-related potentials (ERPs), including P50, N100, and P200, evoked by paired tone bursts (S1 and S2) in CI children and normal-hearing (NH) controls. Suppressed amplitudes for S2 compared with S1 in these three ERPs reflected sensory gating during early and later phases, respectively. A Swanson, Nolan, and Pelham IV (SNAP-IV) scale was performed to assess the attentional performance.Results: Significant amplitude differences between S1 and S2 in N100 and P200 were observed in both NH and CI children, indicating the presence of sensory gating in the two groups. However, the P50 suppression was only found in NH children and not in CI children. Furthermore, the duration of deafness was significantly positively correlated with the score of inattention in CI children.Conclusion: Auditory sensory gating can develop but is deficient during the early phase in CI children. Long-term auditory deprivation has a negative effect on sensory gating and attentional performance.

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The impact of mild-to-severe hearing loss on the neural dynamics serving verbal working memory processing in children

Cited by 11 publications

References 86 publications

Amount of Hearing Aid Use Impacts Neural Oscillatory Dynamics Underlying Verbal Working Memory Processing for Children With Hearing Loss

Amount of Hearing Aid Use Impacts Neural Oscillatory Dynamics Underlying Verbal Working Memory Processing for Children With Hearing Loss

Auditory experience modulates fronto-parietal theta activity serving fluid intelligence

Auditory Sensory Gating in Children With Cochlear Implants: A P50-N100-P200 Study

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