The impact of metformin therapy on hepatic glucose production and skeletal muscle glycogen synthase activity in overweight type II diabetic patients

Johnson, Andrew B.; Webster, J.M.; Sum, Chee Fang; Heseltine, Lesley; Argyraki, M.; Cooper, Brendan; Taylor, Roy

doi:10.1016/0026-0495(93)90284-u

Cited by 140 publications

(73 citation statements)

References 33 publications

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“…For type-2 diabetics, oral agents (sulfonylurea or oral hypoglycemic agents, Metformin, DPP-4 inhibitors, SGLT-2 inhibitors, thiazolidinediones) can be used alone or in combination with insulin; these treatments can be shifted to insulin with metformin if they remain uncontrolled on oral agents. Metformin should be prescribed to type-2 diabetic patients (if not contraindicated) because metformin has cardiovascular protective effects, reduces insulin resistance, increases insulin sensitivity, and decreases the serum lipids while elevates HDL-C as has been demonstrated by research studies [63][64][65][66][67][68][69][70]. It is recommended following best available guidelines for the management of diabetes and its complications [71,72].…”

Section: Discussionmentioning

confidence: 99%

Association of Serum Lipids with High Blood Pressure and Hypertensionamong Diabetic Patients. Mathematical Regression Models to PredictBlood Pressure from Lipids. An Experience from 12-year Follow Up ofmore than 9000 Patients' Cohort

Aziz¹

2017

Gen Med

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Dyslipidemia and hypertension alone predispose to the risk of coronary artery disease, especially if the patient is diabetic. This risk is increased and multiplied when both dyslipidemia and hypertension coexists. There is a lack of studies and significant data for the correlation or association of blood pressure with serum lipids. The studies conducted in the past showed the conflicting results with poor associations. Furthermore, these studies were not conducted on diabetic subjects and lack regression models or mathematical linear equations. Hence, we conducted a prospective, observational cohort study on 9340 diabetic subjects for the duration of 12 year (2005)(2006)(2007)(2008)(2009)(2010)(2011)(2012)(2013)(2014)(2015)(2016)(2017), with the aim to find significant associations, correlations between serum lipids (total cholesterol, triglycerides, LDL-C, HDL-C and Non-HDL-C) and blood pressure (systolic and diastolic). Our data has demonstrated that total cholesterol, triglycerides, and LDL-C were significantly correlated with systolic and diastolic BP, and raised among hypertensive patients as compared to non-hypertensive ( p<0.001 for all lipids). The highest correlations were found between Non-HDL-C with systolic and diastolic blood pressures (r=0.414 and r=0.415, respectively with p<0.001). However, HDL-C was inversely correlated with systolic and diastolic BP and was raised among non-hypertensive patients. Regression models and mathematical linear equations were developed to estimate increasing blood pressure by the given serum lipid levels. All regression models were significant (p<0.0001). We concluded and developed regression models, for the first time in medical research that high lipid levels contribute to the development of increase systolic and diastolic blood pressures. With triglycerides, total-cholesterol, and HDL-C, Non-DHL-C levels should also be calculated in diabetology clinics and general practice. Screening should be done for diabetic patients to detect high blood pressure (or HTN) and elevated serum lipids, and early initiation of management to prevent diabetes complications.

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Section: Discussionmentioning

confidence: 99%

Association of Serum Lipids with High Blood Pressure and Hypertensionamong Diabetic Patients. Mathematical Regression Models to PredictBlood Pressure from Lipids. An Experience from 12-year Follow Up ofmore than 9000 Patients' Cohort

Aziz¹

2017

Gen Med

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“…One candidate mechanism is the activation of AMP-activated protein kinase (AMPK) [25]. It has been recognized that metformin has multiple activities, including suppression of hepatic glucose production and improvement of peripheral insulin sensitivity, in T2DM patients [8,10,18]. These results suggest that STZ-ZF rats are useful not only for studies of diabetes, but also for the screening of pharmacologically valuable hypoglycemic agents.…”

Section: Discussionmentioning

confidence: 99%

Characterization of STZ-Induced Type 2 Diabetes in Zucker Fatty Rats

et al. 2008

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“…Metformin, however, is still popularly prescribed as a treatment for type 2 diabetes. Metformin decreases hepatic gluconeogenesis (27,28) and increases insulin sensitivity (29). It is a potent activator of adenosine monophosphateactivated protein kinase (30) and thereby inhibits the mammalian target of rapamycin (mTOR) (31), a protein kinase that is involved in the control of cellular proliferation and is implicated in tumor growth (32,33).…”

Section: Glucose and Insulin Homeostasismentioning

confidence: 99%

Dietary Interventions to Extend Life Span and Health Span Based on Calorie Restriction

Minor

Allard

Younts

et al. 2010

The Journals of Gerontology Series A: Biological Sciences and M

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The societal impact of obesity, diabetes, and other metabolic disorders continues to rise despite increasing evidence of their negative long-term consequences on health span, longevity, and aging. Unfortunately, dietary management and exercise frequently fail as remedies, underscoring the need for the development of alternative interventions to successfully treat metabolic disorders and enhance life span and health span. Using calorie restriction (CR)-which is well known to improve both health and longevity in controlled studies-as their benchmark, gerontologists are coming closer to identifying dietary and pharmacological therapies that may be applicable to aging humans. This review covers some of the more promising interventions targeted to affect pathways implicated in the aging process as well as variations on classical CR that may be better suited to human adaptation.

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The impact of metformin therapy on hepatic glucose production and skeletal muscle glycogen synthase activity in overweight type II diabetic patients

Cited by 140 publications

References 33 publications

Association of Serum Lipids with High Blood Pressure and Hypertensionamong Diabetic Patients. Mathematical Regression Models to PredictBlood Pressure from Lipids. An Experience from 12-year Follow Up ofmore than 9000 Patients' Cohort

Association of Serum Lipids with High Blood Pressure and Hypertensionamong Diabetic Patients. Mathematical Regression Models to PredictBlood Pressure from Lipids. An Experience from 12-year Follow Up ofmore than 9000 Patients' Cohort

Characterization of STZ-Induced Type 2 Diabetes in Zucker Fatty Rats

Dietary Interventions to Extend Life Span and Health Span Based on Calorie Restriction

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