The impact of metformin on the Bcl-2/Bax/Caspase3 signaling pathway in placental tissue of preeclampsia rats
Huiniu HAO,
Fang Wang,
Ran Jia
et al.
Abstract:Background: Preeclampsia (PE) is one of the leading complications affecting pregnant women globally during the perinatal period, with excessive apoptosis of trophoblast cells playing a crucial role in its pathogenesis. While Metformin (MET) has shown promise in preventing or treating PE, its mechanisms remain unclear.
Objective: We sought to establish a PE rat model and evaluate MET's impact on the intrinsic (mitochondrial) apoptotic pathway (Bcl-2/Bax/Caspase3) in placental cells. We investigated whether MET… Show more
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