The impact of meningococcal conjugate vaccine (MenACWY-TT) on meningococcal carriage in Hajj Pilgrims returning to Turkey

Tezer, Hasan; Gülhan, Belgi̇n; Gişi, Ayşe Simge; Ötgün, Selin Nar; Kanık-Yüksek, Saliha; Özkaya-Parlakay, Aslınur; Kılıç, Selçuk; Şahin, Nuriye Ünal; Şimşek, Asiye Çiğdem; Kara, Ateş

doi:10.1080/21645515.2019.1680084

Cited by 9 publications

(15 citation statements)

References 16 publications

(21 reference statements)

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“…All: 27.4 - A: 0.3 - B: 1.7 - W135: 25.0 - Y: 0.3 III. Household contacts post Hajj 2010: 25.6 Children and adults (NR): 25.6 All: 25.6 W135: 25.6 Adults (20–70 y): 2.5 Turkey [ 122 ] Cohort study Esenboğa Airport (Ankara) Pilgrims N = 229 (pre-Hajj, paired cohort) N = 229 (post-Hajj, paired cohort) Hajj study I. Pre-Hajj 2018: 3.9 I. Children and adults (10–80 y): 3.9 I.…”

Section: Objective 1: Asymptomatic Meningococcal Carriagementioning

confidence: 99%

“…household contacts, military personnel, pilgrims or students), the most extensive data were available in the pilgrim population (Table 1 ). Data were available from Iran (n = 6) [ 33 – 38 ], Kuwait (n = 1) [ 39 ], Saudi Arabia (n = 6) [ 40 – 45 ], and Turkey (n = 3) [ 46 – 48 ]. Asymptomatic carriage rates ranged from 4.2% (Turkey) [ 46 ] to 32.9% (Iran) [ 35 ] in the military risk group (n = 3 studies), from 0.0% (Iran [ 36 ], Kuwait [ 39 ]) to 27.4% (Turkey [ 47 ]) in the pilgrim risk group (n = 11 studies) and from 6.9 to 12.3% (both Iran [ 37 , 38 ]) in the student risk group (n = 2 studies).…”

Section: Objective 1: Asymptomatic Meningococcal Carriagementioning

confidence: 99%

See 1 more Smart Citation

Systematic review of invasive meningococcal disease epidemiology in the Eastern Mediterranean and North Africa region

Dogu

Oordt-Speets²,

Bruijn³

et al. 2021

BMC Infect Dis

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Background Invasive meningococcal disease (IMD) represents a global health burden. However, its epidemiology in the Eastern Mediterranean (EM) and North Africa (NA) regions is currently not well understood. This review had four key objectives: to describe asymptomatic meningococcal carriage, IMD epidemiology (e.g. serogroup prevalence, case-fatality rates [CFRs]), IMD presentation and management (e.g. clinical diagnosis, antibiotic treatments) and economic impact and evaluation (including health technology assessment [HTA] recommendations) in EM and NA. Methods A systematic literature search (MEDLINE and EMBASE) was conducted (January 2000 to February 2021). Search strings included meningococcal disease and the regions/countries of interest. Identified publications were screened sequentially by title/abstract, followed by screening of the full-text article; articles were also assessed on methodological quality. Literature reviews, genetic sequencing or diagnostic accuracy studies, or other non-pertinent publication type were excluded. An additional grey literature search (non-peer-reviewed sources; start date January 2000) was conducted to the end of April 2019. Results Of the 1745 publications identified, 79 were eligible for the final analysis (n = 61 for EM and n = 19 for NA; one study was relevant to both). Asymptomatic meningococcal carriage rates were 0–33% in risk groups (e.g. military personnel, pilgrims) in EM (no data in NA). In terms of epidemiology, serogroups A, B and W were most prevalent in EM compared with serogroups B and C in NA. IMD incidence was 0–20.5/100,000 in EM and 0.1–3.75/100,000 in NA (reported by 7/15 countries in EM and 3/5 countries in NA). CFRs were heterogenous across the EM, ranging from 0 to 57.9%, but were generally lower than 50%. Limited NA data showed a CFR of 0–50%. Data were also limited in terms of IMD presentation and management, particularly relating to clinical diagnosis/antibiotic treatment. No economic evaluation or HTA studies were found. Conclusions High-risk groups remain a significant reservoir of asymptomatic meningococcal carriage. It is probable that inadequacies in national surveillance systems have contributed to the gaps identified. There is consequently a pressing need to improve national surveillance systems in order to estimate the true burden of IMD and guide appropriate prevention and control programmes in these regions.

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Section: Objective 1: Asymptomatic Meningococcal Carriagementioning

confidence: 99%

Section: Objective 1: Asymptomatic Meningococcal Carriagementioning

confidence: 99%

Systematic review of invasive meningococcal disease epidemiology in the Eastern Mediterranean and North Africa region

Dogu

Oordt-Speets²,

Bruijn³

et al. 2021

BMC Infect Dis

View full text Add to dashboard Cite

show abstract

“…For the 2018 Hajj, of 229 Hajj pilgrims aged 10-80 years (all of whom had received conjugated MenACWY vaccine at least 2 weeks prior to sampling), carriage was identified in 3.9% immediately prior to departure (all of which were MenB). Following their return, although overall carriage rates were not reported, paired sampling found MenB acquisition in 1/229 (0.4%) of returning pilgrims [89].…”

Section: Carriagementioning

confidence: 91%

“…MenW (66.6%) was the most prevalent serogroup, with 9.4% of isolates due to MenB [87]. Data for carriage in Turkish pilgrims are available for both the 2010 and 2018 Hajj [88,89]. In 2010, carriage was identified in 13.3% of pilgrims prior to departure, the majority being MenW (82.5%) followed by MenB (14.3%).…”

Section: Carriagementioning

confidence: 99%

Meningococcal Disease and Immunization Activities in Hajj and Umrah Pilgrimage: a review

Badur¹,

Khalaf²,

Öztürk³

et al. 2022

Infect Dis Ther

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Invasive meningococcal disease (IMD) outbreaks associated with Hajj and Umrah pilgrimage events in the Kingdom of Saudi Arabia (KSA) are well recognized. Past outbreaks have been associated with substantial intercontinental spread of specific Neisseria meningitidis serogroups. The emergence of meningococcal serogroup W (MenW) was a global concern following the 2000/2001 Hajj outbreaks. Broader compulsory meningococcal serogroups A, C, W and Y (MenACWY) immunization S. Badur (&) EM, Vaccines Scientific Affairs and Public Health, GSK, Bu ¨yu ¨kdere Caddesi No:173,

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“…Since then, vaccination of participants has been carried out. 16,17 At the 23rd World Scout Jamboree (WSJ2015) held in Japan in 2015, it was reported that three Scouts from the North Scotland Corps and one Scout from the Swedish Corps developed meningococcal infection. 18,19 In addition, epidemics of infectious diseases such as influenza, measles, and norovirus 20 have been reported at mass gathering events.…”

Section: Risks and Benefits Of Mass Gathering Events For The Local Health-care Systemmentioning

confidence: 99%

Medicine at mass gatherings: current progress of preparedness of emergency medical services and disaster medical response during 2020 Tokyo Olympic and Paralympic Games from the perspective of the Academic Consortium (AC2020)

Morimura

Mizobata²,

Sugita

et al. 2021

Acute Medicine & Surgery

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Mass gatherings are events characterized by "the concentration of people at a specific location for a specific purpose over a set period of time that have the potential to strain the planning and response resources of the host country or community." Previous reports showed that, as a result of the concentration of people in the limited area, injury and illness occurred due to several factors. The response plan should aim to provide timely medical care to the patients and to reduce the burden on emergency hospitals, and to maintain a daily emergency medical services system for residents of the local area. Although a mass gathering event will place a significant burden on the local health-care system, it can provide the opportunity for long-term benefits of public health-care and improvement of daily medical service systems after the end of the event. The next Olympic and Paralympic Games will be held in Tokyo, during which mass gatherings will occur on a daily basis in the context of the coronavirus disease (COVID-19) epidemic. The Academic Consortium on Emergency Medical Services and Disaster Medical Response Plan during the Tokyo Olympic and Paralympic Games in 2020 (AC2020) was launched 2016, consisting of 28 academic societies in Japan, it has released statements based on assessments of medical risk and publishing guidelines and manuals on its website. This paper outlines the issues and countermeasures for emergency and disaster medical care related to the holding of this big event, focusing on the activities of the academic consortium.

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The impact of meningococcal conjugate vaccine (MenACWY-TT) on meningococcal carriage in Hajj Pilgrims returning to Turkey

Cited by 9 publications

References 16 publications

Systematic review of invasive meningococcal disease epidemiology in the Eastern Mediterranean and North Africa region

Systematic review of invasive meningococcal disease epidemiology in the Eastern Mediterranean and North Africa region

Meningococcal Disease and Immunization Activities in Hajj and Umrah Pilgrimage: a review

Medicine at mass gatherings: current progress of preparedness of emergency medical services and disaster medical response during 2020 Tokyo Olympic and Paralympic Games from the perspective of the Academic Consortium (AC2020)

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