The Impact of Maternal Vitamin D Status on Offspring Brain Development and Function: a Systematic Review

Pet, M. A.; Brouwer‐Brolsma, Elske M.

doi:10.3945/an.115.010330

Cited by 48 publications

(44 citation statements)

References 60 publications

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“…Another study conducted in Spain reported that infants of mothers with a concentration of 25 (OH) D3 at a pregnancy >30 ng/mL (>75 nmol/L) showed higher mental scores and psychomotor scores compared with mothers with a 25 (OH) D3 concentration <20 ng/mL or <50 nmol/L . However, other studies reported no relation between neonatal vitamin D status and neurocognitive development in infants …”

Section: Discussionmentioning

confidence: 99%

Association of maternal vitamin D deficiency and infants' neurodevelopmental status: A cohort study on vitamin D and its impact during pregnancy and childhood in Indonesia

Dhamayanti

Noviandhari

Supriadi

et al. 2019

J Paediatrics Child Health

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Aim: Vitamin D deficiency in early pregnancy may cause the disruption of fetal brain development and neurodevelopmental function. This study aimed to explore the extent of neurodevelopment disruption could be associated with maternal vitamin D deficiency. Methods: A cohort study was conducted in Sukabumi and Waled, West Java, Indonesia, beginning in July 2016. Maternal serum 25(OH)-vitamin D was measured between 10 and 14 weeks of gestational age. Child development was measured using the Ages and Stages Questionnaire-3 (ASQ-3) at age 3, 6 and 12 months. Results: A total of 141 mother-infant pairs participated. One pair was excluded due to anencephaly of the infant. Vitamin D deficiency was found in 27 (19%) mothers, but delays occurred in gross motor function among 104 (76.1%) infants and in problem-solving functions among 61 (43.7%) infants at 3 months old. In general, the mean ASQ score at ages 3 and 6 months were lower among infants whose mothers had a vitamin D deficiency. The mean ASQ score for gross motor function at age 3 months was found to be significantly lower among these infants (31.5 vs. 37.9; P = 0.02), with increased risk for delayed motor function at age 3 months (relative risk (95% confidence interval) = 1.22 (1.09-1.49); P = 0.03). Conclusion: Neurodevelopmental function disruptions among infants whose mothers had vitamin D deficiency during pregnancy were reflected in lower ASQ scores, in which gross motor function was significantly impaired at 3 months of age. CovariateThe covariates in this study were maternal age, parity status, parents' education status (low, middle, high) and parental income. Characteristics of infants included gestational age, gender (male/female), exclusive breastfeeding (yes/no) and complementary feeding.

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Section: Discussionmentioning

confidence: 99%

Association of maternal vitamin D deficiency and infants' neurodevelopmental status: A cohort study on vitamin D and its impact during pregnancy and childhood in Indonesia

Dhamayanti

Noviandhari

Supriadi

et al. 2019

J Paediatrics Child Health

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“…The VD diffuses through the placenta from mother to the developing fetus. Therefore, maternal deficiency of VD is associated with fetal VD deficiency, as our results show in Figure .…”

Section: Discussionmentioning

confidence: 99%

Congenital laryngomalacia: Is it an inflammatory disease? The role of vitamin D

et al. 2019

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Objectives/Hypothesis Laryngomalacia is the most common cause of stridor in infants. The exact pathophysiology is still not well understood. Our objective was to investigate whether laryngomalacia is an inflammatory disease, focusing on the possible role of vitamin D. Study Design Case‐control study. Methods Sixty Egyptian infants and 60 mothers were included in this study. They were divided into four equal groups (n = 30 for each): infants with laryngomalacia (LM‐infants), control infants (C‐infants), mothers of the infants with laryngomalacia (LM‐mothers), and mothers of the control infants (C‐mothers). Laryngoscopy was performed and serum 25‐hydroxyvitamin D (25[OH]‐vitamin‐D) and interleukin 6 (IL‐6) were estimated. Results Significant increase of serum IL‐6 associated with a significant decrease in serum 25(OH)‐vitamin D was observed in the LM‐infants compared to the C‐infants (P < .001 for both). LM‐mothers had significantly lower 25(OH)‐vitamin D status compared to C‐mothers (P < .001). Conclusions Deficiency of 25(OH)‐vitamin D in LM‐infants may result in dysregulation of the immune responses with elevation of a proinflammatory cytokine (IL‐6). Laryngomalacia could be an inflammatory disease due to 25(OH)‐vitamin D deficiency as evidenced by the high level of IL‐6. This finding may open the door to the appropriate prevention, diagnosis, and treatment, especially for moderate to severe laryngomalacia. Level of Evidence 3b Laryngoscope, 130:448–453, 2020

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“…23 A cohort study in the United States assessing the relationship between cord blood vitamin D and developmental and cognitive achievement scores, showed that an increase in 5 nmol/L of vitamin D levels in the cord blood was associated with a very small increase in the Wechsler Intelligence Scale for Children (WISC) score at the age of seven years old. 8,24 Other study in Australia stated that cord blood vitamin D level had a positive association with language development in children aged 18 months and 4 years old, although the association was weak. 9 Thus, it could be concluded that vitamin D has an effect on child development, despite the weak association found on the currently available evidence.…”

Section: Discussionmentioning

confidence: 99%

Cord blood vitamin D is correlated with problem solving domain in early childhood neurodevelopment: A Cohort Study on Vitamin D Status and Its Impact during Pregnancy and Childhood in Indonesia

Supriadi¹,

Gumilang²,

Setiabudi³

et al. 2020

Preprint

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Fetal vitamin D level is known to influence brain development and subsequent postnatal neurodevelopment, although several studies stated that this correlation remains controversial. We aimed to determine the correlation between cord blood vitamin D level and neurodevelopmental status in the first 1000 days of life. This was a cohort study, located in Sukabumi and Waled districts of West Java, Indonesia, from 2016–2019. Subjects were term infants with no congenital abnormalities, born from pregnant women involved in a previously conducted cohort study. The cord blood sample collected at delivery was used to measure 25 (OH)-vitamin D level. Neurodevelopmental status was examined after the infants reached 6, 12, and 24 months of age using Ages and Stages Questionnaire-3 (ASQ-3). Statistical analysis was performed using rank Spearman’s correlation. Blood samples were collected from 116 subjects. The mean value of vitamin D levels was 16.2 ng/mL (8.0–35.4 ng/mL). As many as 12.9%, 65.5% and 21.6% of newborns had vitamin D deficiency, insufficiency and normal vitamin D levels. The correlation was found between cordblood vitamin D levels and the problem-solving domain at the age of 12 and 24 months old; r = 0.217, and r = 0.414 respectively. Multiple linier regression analysis result showed a decrease problem solving domain score of 0.641 was associated with decreased of vitamin D. Cordblood vitamin D level correlates with infant neurodevelopmental status. Screening of vitamin D level is crucial during pregnancy and early childhood to improve neurodevelopmental outcome.

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The Impact of Maternal Vitamin D Status on Offspring Brain Development and Function: a Systematic Review

Cited by 48 publications

References 60 publications

Association of maternal vitamin D deficiency and infants' neurodevelopmental status: A cohort study on vitamin D and its impact during pregnancy and childhood in Indonesia

Association of maternal vitamin D deficiency and infants' neurodevelopmental status: A cohort study on vitamin D and its impact during pregnancy and childhood in Indonesia

Congenital laryngomalacia: Is it an inflammatory disease? The role of vitamin D

Cord blood vitamin D is correlated with problem solving domain in early childhood neurodevelopment: A Cohort Study on Vitamin D Status and Its Impact during Pregnancy and Childhood in Indonesia

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