The impact of maternal major depression, anxiety disorders and their comorbidities on gestational age, birth weight, preterm birth and low birth weight in newborns

Uğuz, Faruk; Yakut, Eda; Aydogan, Semra; Bayman, Melike Geyik; Gezginç, Kazım

doi:10.1016/j.jad.2019.08.076

Cited by 25 publications

(12 citation statements)

References 19 publications

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“…It indicates that all these studies considered a minimum score of EPDS to determine gestational depression. Few others utilized other measures, i.e., the Center for Epidemiological Studies-Depression (CES-D) scale, the 9-item Patient Health Questionnaire (PHQ-9), and other custom questionnaires (studies in references [5,8,[11][12][13][14][15]20,21]).…”

Section: Depression Measuresmentioning

confidence: 99%

Untreated Depression During Pregnancy and Its Effect on Pregnancy Outcomes: A Systematic Review

Jahan¹,

Went²,

Sultan³

et al. 2021

Cureus

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Depression is characterized by sad, irritated, or empty moods, as well as somatic and cognitive changes such as loss of concentration, anhedonia, hopelessness, loss of appetite, sleep disturbances, and suicidal ideation, all of which have a negative impact on an individual's ability to function. Depression that occurs during pregnancy is known as antenatal depression. The occurrence of depression during pregnancy and afterward is quite high. Women having a history of depression before pregnancy have a high probability of getting depression during pregnancy again. The purpose of the study is to review the effect of untreated depression during pregnancy on maternal and neonatal outcomes. The primary outcomes of this review were the identification of studies showing the relationship between untreated depression during the pregnancy indicated by depression measures and any associated adverse birth outcomes; specifically, low birth weight, small for gestational age, preterm birth, postpartum depression, and infant neurodevelopmental outcome. We reviewed 20 population-based contemporary cohort studies with a range of populations from 54 to 194,494, all of them representing the population of gestational age located in multiple jurisdictions. It was found that maternal depression during pregnancy has a positive association with preterm birth, small for gestational age, stillbirth, low birth weight, and maternal morbidity including perinatal complications, increased operative delivery, and postpartum depression. To prevent these adverse outcomes, depression should be screened, monitored, and managed appropriately keeping risk-benefit in consideration.

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Section: Depression Measuresmentioning

confidence: 99%

Untreated Depression During Pregnancy and Its Effect on Pregnancy Outcomes: A Systematic Review

Jahan¹,

Went²,

Sultan³

et al. 2021

Cureus

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“…Mental health during pregnancy (e.g., stress, anxiety, pregnancy-related anxiety, and depression) can influence birth outcomes [ 1 ] including preterm birth [ 2 , 3 ] and low birth weight [ 3 ]. Limited studies examining the role of comorbid anxiety and depression in this literature indicate comorbid anxiety and depression may further increase the risk of preterm birth or low birth weight [ 4 , 5 ]. Studies examining immune system pathways to preterm birth demonstrate the plausibility, as a correlation exists between cytokines such as interleukin-6 and interluken-12 and depression, anxiety and perceived stress measured in the second [ 6 ] or third [ 4 ] trimester.…”

Section: Introductionmentioning

confidence: 99%

Comorbid Anxiety and Depression among Pregnant Pakistani Women: Higher Rates, Different Vulnerability Characteristics, and the Role of Perceived Stress

Premji

Lalani

Shaikh

et al. 2020

IJERPH

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Anxiety and depression commonly co-occur during pregnancy and may increase risk of poor birth outcomes including preterm birth and low birth weight. Our understanding of rates, patterns, and predictors of comorbid anxiety and depression is hindered given the dearth of literature, particularly in low- and middle-income (LMI) countries. The aim of this study is (1) to explore the prevalence and patterns of comorbid antenatal anxiety and depressive symptoms in the mild-to-severe and moderate-to-severe categories among women in a LMI country like Pakistan and (2) to understand the risk factors for comorbid anxiety and depressive symptoms. Using a prospective cohort design, a diverse sample of 300 pregnant women from four centers of Aga Khan Hospital for Women and Children in Pakistan were enrolled in the study. Comorbid anxiety and depression during pregnancy were high and numerous factors predicted increased likelihood of comorbidity, including: (1) High level of perceived stress at any time point, (2) having 3 or more previous children, and (3) having one or more adverse childhood experiences. These risks were increased if the husband was employed in the private sector. Early identification and treatment of mental health comorbidities may contribute to decreased adverse birth outcomes in LMI countries.

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“…41,42 In addition, anxiety disorders and their comorbidity with depression are also associated with negative birth outcomes such as preterm birth, spontaneous abortion, and low birth weight. 1,43 In conclusion, the results of the available metaanalyses suggest that newborns or children of mothers who use antidepressants during their pregnancy may be at a higher risk of the specific outcomes examined in this review, compared to mothers who do not use these medications. Despite the higher risks with the use of antidepressants, the absolute risk appears to be low.…”

Section: Discussionmentioning

confidence: 76%

“…It has been suggested that anxiety disorders are more prevalent than depression in pregnant women and their comorbidity is not rare 41,42 . In addition, anxiety disorders and their comorbidity with depression are also associated with negative birth outcomes such as preterm birth, spontaneous abortion, and low birth weight 1,43 …”

Section: Discussionmentioning

confidence: 99%

Neonatal and Childhood Outcomes in Offspring of Pregnant Women Using Antidepressant Medications: A Critical Review of Current Meta‐Analyses

Uğuz

2020

The Journal of Clinical Pharma

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This article reviewed the results of 21 recent meta‐analyses examining the relationship between maternal use of antidepressants during pregnancy and negative outcomes in newborns and children. PubMed was searched for meta‐analyses published in English between January 1, 2011, and November 30, 2019, by using combinations of the keywords pregnancy, antidepressants, review, meta‐analysis, selective serotonin reuptake inhibitors, selective serotonin‐norepinephrine reuptake inhibitors, tricyclic antidepressants, neonatal outcomes, autism spectrum disorders, attention deficit hyperactivity disorder (ADHD), preterm birth, low birth weight, spontaneous abortion, persistent pulmonary hypertension, infant, newborn, children, and offspring. The present review included a total of 21 relevant meta‐analyses that met the inclusion criteria. Most of the meta‐analyses reported that compared to non‐users, the risks of preterm birth, low birth weight, spontaneous abortion, persistent pulmonary hypertension, autism spectrum disorders, and ADHD in offspring of antidepressant users were significantly higher. Some meta‐analyses also noted that the elevated risks were no longer statistically significant when pregnant women with psychiatric diagnoses treated with an antidepressant were compared with control patients who remained untreated. Although this review of current meta‐analyses suggests a moderately increased risk of neonatal and childhood outcomes assessed with maternal use of antidepressants, it is difficult to ascertain whether these outcomes are independent of underlying maternal psychiatric disorders.

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The impact of maternal major depression, anxiety disorders and their comorbidities on gestational age, birth weight, preterm birth and low birth weight in newborns

Cited by 25 publications

References 19 publications

Untreated Depression During Pregnancy and Its Effect on Pregnancy Outcomes: A Systematic Review

Untreated Depression During Pregnancy and Its Effect on Pregnancy Outcomes: A Systematic Review

Comorbid Anxiety and Depression among Pregnant Pakistani Women: Higher Rates, Different Vulnerability Characteristics, and the Role of Perceived Stress

Neonatal and Childhood Outcomes in Offspring of Pregnant Women Using Antidepressant Medications: A Critical Review of Current Meta‐Analyses

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