The impact of marital status on stage at diagnosis and survival of female patients with breast and gynecologic cancers: A meta-analysis

Yuan, Ruixia; Chao, Zhang; Li, Qi; Ji, Mei; He, Nannan

doi:10.1016/j.ygyno.2021.06.008

Cited by 29 publications

(23 citation statements)

References 60 publications

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“…Univariate and multivariate analysis showed that marital status significantly impacted survival in UTUC with bone metastasis. Many studies have shown that marital status is an important factor affecting the prognosis of cancer patients, and married patients generally have a better prognosis due to the economic and emotional support ( 25 – 27 ). Married patients were more likely to gain curative treatment, high-quality care, and support of their spouse ( 28 , 29 ).…”

Section: Discussionmentioning

confidence: 99%

Clinical features and prognostic indicators in upper-tract urothelial carcinoma with bone metastasis

et al. 2022

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PurposeWith the gradual increase in the incidence of upper-tract urothelial carcinoma (UTUC), its metastatic disease has attracted much attention. The prognosis of UTUC patients with bone metastasis is worse than that of UTUC patients with other metastases. Therefore, the current study is performed to analyze the clinicopathologic features and survival predictors among UTUC patients with bone metastasis.Patients and methodsWe reviewed the Surveillance, Epidemiology, and End Results (SEER) database to select cases diagnosed with UTUC and bone metastasis at present from 2010 to 2016. Overall survival (OS) and cancer-specific survival (CSS) were first performed by applying univariate Cox regression analysis. Then we performed multivariate Cox analysis to determine independent predictors of survival. Forest plots were drawn by GraphPad 8.0.1 and used to visually display the results of multivariate analysis. Kaplan-Meier method was applied to intuitively show the prognosis difference of each independent risk factor.ResultsWe finally identified 380 UTUC patients with bone metastasis for survival analysis, of which 230 males (60.5%) and 150 females (39.5%). The mean and median age at diagnosis were 71 and 72 years, respectively. Simultaneous lung metastasis (33.4%) and liver metastasis (31.1%) were more common in UTUC patients with bone metastasis. The 1-year OS and CSS rates of this research population were 23.8% and 26.6%, respectively. Multivariate Cox proportional hazards modeling controlling for surgery, chemotherapy, brain metastasis, liver metastasis, lung metastasis, and marital status, revealed that surgery, chemotherapy, no liver metastasis, no lung metastasis, and married status predicted for better OS and CSS.ConclusionSurgery and chemotherapy are optimal management of UTUC patients with bone metastasis. Active treatments on lung and liver metastases should be performed. The prognosis of patients with unmarried status or others should be further improved.

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Section: Discussionmentioning

confidence: 99%

Clinical features and prognostic indicators in upper-tract urothelial carcinoma with bone metastasis

et al. 2022

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“…The results highlight the importance of reducing health disparities in the unmarried population. A meta-analysis assessing the impact of socio-economic factors on stage at diagnosis and survival of female patients with gynecological cancers found a 28% increased risk of late-stage diagnosis and a 20% higher risk of death among unmarried female cancer patients, confirming the significant protective effect of marriage against mortality associated with gynecological cancers [Yuan et al, 2021]. The protective effect of marriage may be explained by lifestyle and health-related behaviors, as close partners may recognize cancer-related symptoms in time and encourage their spouse to participate in screening or seek medical advice [Osazuwa-Peters et al, 2019].…”

Section: Discussionmentioning

confidence: 99%

Underlying reasons for post-mortem diagnosed lung cancer cases – A robust retrospective comparative study from Hungary (HULC study)

Kiss

Bogos

Tamási

et al. 2022

Preprint

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Objective The Hungarian Undiagnosed Lung Cancer (HULC) study aimed to explore the potential reasons for missed LC diagnosis by comparing healthcare and socio–economic data among patients with post –mortem diagnosed LC with those who were diagnosed with LC during their lives. Methods This nationwide, retrospective study used the databases of the Hungarian Central Statistical Office (HCSO) and National Health Insurance Fund (NHIF) to identify patients who died between January 1, 2019 and December 31, 2019 and were diagnosed with lung cancer post-mortem (population A) or during their lifetime (population B). Patient characteristics, socio –economic factors, and healthcare resource utilization (HCRU) data were compared between the diagnosed and undiagnosed patient population. Results During the study period, 8,435 patients were identified from the HCSO database with LC as the cause of death, of whom 1,203 (14.24%) had no LC –related ICD code records in the NHIF database during their lives (post-mortem diagnosed LC population). Post –mortem diagnosed LC patients were significantly older than patients diagnosed while still alive (mean age 71.20 vs. 68.69 years, p<0.001), with a more pronounced age difference among female patients (difference: 4.57 years, p<0.001), and had significantly fewer GP and specialist visits, X –ray and CT scans within 7 to 24 months and 6 months before death, although the differences in GP and specialist visits within 7 –24 months did not seem clinically relevant. Patients diagnosed with LC while still alive were more likely to be married (47.62% vs. 33.49%), had higher educational attainment, and had more children, than patients diagnosed with LC post –mortem. Conclusions Post-mortem diagnosed lung cancer accounts for 14.24% of total lung cancer mortality in Hungary. This study provides valuable insights into patient characteristics, socio –economic factors, and HCRU data potentially associated with a high risk of lung cancer misdiagnosis.

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“…Patients who were never married or in other marital statuses had a higher risk of all-cause death, kidney cancer-specific death, and other noncancer deaths than married patients. The fact that marriage provides social support may partly explain this finding ( 14 , 26 , 27 ).…”

Section: Discussionmentioning

confidence: 99%

“…In our study, patients with stage IV disease had a higher SMR in heart disease than those with stage I/II and III (SMR, 1.92; 95% CI, 1.72–2.14 for stage IV; SMR, 1.23; 95% CI, 1.14–1.32 for stage III; SMR, 1.23; 95% CI, 1.19–1.27 for stage I/II). In the past decade, several tyrosine kinases and vascular endothelial growth factor inhibitors have been used for first-line therapies in patients with metastatic RCC ( 13 , 14 ). These drugs greatly improved the survival rate of patients with metastatic RCC.…”

Section: Discussionmentioning

confidence: 99%

Cause of Death During Renal Cell Carcinoma Survivorship: A Contemporary, Population-Based Analysis

Chen²,

Wu³

et al. 2022

Front. Oncol.

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BackgroundAs the survival rates of patients with renal cell carcinoma (RCC) continue to increase, noncancer causes of death cannot be ignored. The cause-specific mortality in patients with RCC is not well understood.ObjectiveOur study aimed to explore the mortality patterns of contemporary RCC survivors.MethodsWe performed a retrospective cohort study involving patients with RCC from the Surveillance, Epidemiology, and End Results (SEER) database. We used standardized mortality ratios (SMRs) to compare the death rates in patients with RCC with those in the general population.ResultsA total of 106,118 patients with RCC, including 39,630 who died (27%), were included in our study. Overall, compared with the general US population, noncancer SMRs were increased 1.25-fold (95% confidence intervals [CI], 1.22 to 1.27; observed, 11,235), 1.19-fold (95% CI, 1.14 to 1.24; observed, 2,014), and 2.24-fold (95% CI, 2.11 to 2.38; observed, 1,110) for stage I/II, III, and IV RCC, respectively. The proportion of noncancer causes of death increased with the extension of survival time. A total of 4,273 men with stage I/II disease (23.13%) died of RCC; however, patients who died from other causes were 3.2 times more likely to die from RCC (n = 14,203 [76.87%]). Heart disease was the most common noncancer cause of death (n = 3,718 [20.12%]; SMR, 1.23; 95% CI, 1.19–1.27). In patients with stage III disease, 3,912 (25.98%) died from RCC, and 2,014 (13.37%) died from noncancer causes. Most patients (94.99%) with stage IV RCC died within 5 years of initial diagnosis. Although RCC was the leading cause of death (n = 12,310 [84.65%]), patients with stage IV RCC also had a higher risk of noncancer death than the general population (2.24; 95% CI, 2.11–2.38).ConclusionsNon-RCC death causes account for more than 3/4 of RCC survivors among patients with stage I/II disease. Patients with stage IV are most likely to die of RCC; however, there is an increased risk of dying from septicemia, and suicide cannot be ignored. These data provide the latest and most comprehensive assessment of the causes of death in patients with RCC.

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The impact of marital status on stage at diagnosis and survival of female patients with breast and gynecologic cancers: A meta-analysis

Cited by 29 publications

References 60 publications

Clinical features and prognostic indicators in upper-tract urothelial carcinoma with bone metastasis

Clinical features and prognostic indicators in upper-tract urothelial carcinoma with bone metastasis

Underlying reasons for post-mortem diagnosed lung cancer cases – A robust retrospective comparative study from Hungary (HULC study)

Cause of Death During Renal Cell Carcinoma Survivorship: A Contemporary, Population-Based Analysis

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