The impact of marital status at diagnosis on cancer survival in patients with differentiated thyroid cancer

Shi, Rong; Qu, Ning; Lü, Zhong; Liao, Tian; Gao, Yi; Ji, Qing

doi:10.1002/cam4.778

Cited by 54 publications

(60 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In terms of gender and race, previous studies have shown that males and/or blacks are high risk groups for DTC, and that marriage was a protective against DTC (5,35). In our study, being male, being black, and being single were the only risk factors for DTC.…”

Section: Discussionsupporting

confidence: 51%

Comparison of Survival and Risk Factors of Differentiated Thyroid Cancer in the Geriatric Population

Hong

Han

et al. 2020

Front. Oncol.

View full text Add to dashboard Cite

Purpose: The incidence rate of differentiated thyroid cancer (DTC), the most common type of thyroid cancer, has increased in the past two decades. The present study analyzed the clinical and pathological characteristics of DTC, and discussed the risk factors for survival in elderly age-risk DTC patients.Methods: Elderly patients who were diagnosed with DTC, and subsequently underwent surgery for DTC, were identified from the SEER database . Based on histology, these patients were divided into C-PTC, FV-PTC, and FTC. The clinical characteristics, pathological features, and treatments undertaken were compared among these patients. Cox proportional hazards analysis was performed to evaluate the risk factors to disease-specific survival (DSS). Results:In elderly DTC patients, FV-PTC shows intermediate tumor features compared to C-PTC and FTC, but presented a better outcome. Being male, African-American, tumors sized bigger than 4 cm, extrathyroidal extension, lymph node metastasis, and distant metastasis, were all strong risk factors for DSS in elderly DTC patients (all p < 0.05). No difference was found between lobectomy and total thyroidectomy with respect to DSS, and radiation therapy conferred no apparent advantage with respect to DSS (both p > 0.05).Discussion: Patients with FV-PTC needed more specific histology cataloging and risk assessment, suggesting conservative therapy. Risk stratification should be paid attention to, and treatment should be individualized for elderly patients.

show abstract

Section: Discussionsupporting

confidence: 51%

Comparison of Survival and Risk Factors of Differentiated Thyroid Cancer in the Geriatric Population

Hong

Han

et al. 2020

Front. Oncol.

View full text Add to dashboard Cite

show abstract

“…Another surprising factor was that unmarried patients had a 32% reduced risk of receiving CRN. This has not been reported previously in this setting, but may reflect the observation in many cancers that married patients receive more treatment and better outcomes .…”

Section: Discussionsupporting

confidence: 45%

Cytoreductive nephrectomy for metastatic renal cell carcinoma: inequities in access exist despite improved survival

Patel

Beattie

Bang³

et al. 2017

Cancer Medicine

View full text Add to dashboard Cite

The use of cytoreductive nephrectomy (CRN) in the targeted therapy era is still debated. We aimed to determine factors associated with reduced use of CRN and determine the effect of CRN on overall survival in patients with metastatic renal cell carcinoma (RCC). All advanced RCC diagnosed between 2001 and 2009 in New South Wales, Australia, were identified from the Central Cancer Registry. Records of treatment and death were electronically linked. Follow‐up was to the end of 2011. Multivariable logistic regression analysis was used to determine factors associated with the receipt of CRN. Cox proportional hazards model was used to determine factors associated with survival. A total of 1062 patients were identified with metastatic RCC of whom 289 (27%) received CRN. There was no difference in the use of CRN over the time period of the study. Females (OR 0.68 (95% CI: 0.48–0.96)), unmarried individuals (OR 0.68 (95% CI: 0.48–0.96)), treatment in a nonteaching hospital (OR 0.26 (95% CI: 0.18–0.36)) and individuals without private insurance (OR 0.29 (95% CI: 0.20–0.41)) all had reduced likelihood of receiving CRN. On multivariable analysis, not receiving CRN resulted in a 90% increase in death (HR 1.90 (95% CI: 1.61–2.25)). In addition, increasing age (P < 0.001), increasing Charlson comorbidity status (P = 0.002) and female gender also had a significant independent association with death. Despite a strong association with improved survival, individuals who are elderly, female, have treatment in a nonteaching facility or have no private insurance have a reduced likelihood of receiving CRN.

show abstract

“…This suggests that in the case of unknown lymph node metastasis, the prognosis of regional lymph nodes removed and examined may be better than that of no regional lymph nodes removed and examined. As described in Shi et al [34] and Merrill and Johnson [35], we also found that being married has a positive effect on the prognosis of thyroid cancer in all three analysis methods.…”

Section: Discussionsupporting

confidence: 86%

Prognostic factors in patients with thyroid carcinoma: a competing-risks analysis

Wang

Yang

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Cox proportional-hazards models are widely used to describe survival trends and identify prognostic factors for thyroid carcinoma, but the prognostic model is not accurate enough. This study therefore used a competing-risks model to identify the significant prognostic factors for different types of thyroid carcinoma.Methods: We identified 38,444 eligible patients in the SEER (Surveillance, Epidemiology, and End Result) database. The potential prognostic factors for thyroid carcinoma were analyzed by Cox regression analysis, cause-specific hazard function (CS) analysis, and subdistribution hazard function (SD).Results: Cox regression analysis, CS analysis and SD analysis found identifying age, being unmarried, no regional lymph nodes examined, AJCC-6 II, III, IV vs I , having follicular, medullary, anaplastic vs Papillary carcinomas, no surgery, no radioiodine, liver metastasis, and lung metastasis as the significant risk factors for thyroid carcinoma, while being female was protective factor. However, the results from the three multivariate models for being black, tumor size >1 cm, and brain metastasis were inconsistent.Conclusion: In addition to finding that age, pathological type, tumor size, AJCC-6 stage, surgery status, radioiodine status, metastasis as common factors affected the prognosis, we also found that women, being unmarried and had their regional lymph nodes examined can improve the prognosis of thyroid cancer. The discovery of these factors will provide evidences for the prevention and treatment of thyroid cancer.

show abstract

The impact of marital status at diagnosis on cancer survival in patients with differentiated thyroid cancer

Cited by 54 publications

References 32 publications

Comparison of Survival and Risk Factors of Differentiated Thyroid Cancer in the Geriatric Population

Comparison of Survival and Risk Factors of Differentiated Thyroid Cancer in the Geriatric Population

Cytoreductive nephrectomy for metastatic renal cell carcinoma: inequities in access exist despite improved survival

Prognostic factors in patients with thyroid carcinoma: a competing-risks analysis

Contact Info

Product

Resources

About