The impact of lymphovascular invasion on survival in oral carcinoma

Jones, Helen; Sykes, Andrew J; Bayman, N.; Sloan, Philip; Swindell, Ric; Patel, Mrinali; Musgrove, Brian

doi:10.1016/j.oraloncology.2008.03.009

Cited by 86 publications

(69 citation statements)

References 30 publications

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“…However, contrary to many other reports, lymphovascular invasion was an independent predictor of distant control and overall survival. This finding lines with the report from Jones et al[18] who reports independent prognostic impact of lymphovascular invasion when added to multivariate Cox regression model.…”

Section: Discussionsupporting

confidence: 92%

Outcomes of oral cavity cancer patients treated with surgery followed by postoperative intensity modulated radiation therapy

et al. 2017

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Objectives Although treatment paradigms have not changed significantly, radiotherapy, surgery, and imaging techniques have improved, leading us to investigate oncologic and survival outcomes for oral cavity squamous cell cancer (OCSCC) patients treated with surgery followed by postoperative IMRT. Material and Methods Records of patients with pathological diagnosis of OCSCC treated between 2000–2012 were retrospectively reviewed. Patients’ demographic, disease, and treatment criteria were extracted. Kaplan-Meier method was used to calculate survival curves. Results Two hundred eighty-nine patients were analyzed. Median follow-up was 35 months. Two hundred sixty-eight had neck dissections (93%), of which 66% had nodal involvement, and 51% of those positive dissections had extracapsular extension. Forty patients received induction chemotherapy and 107 received concurrent chemotherapy. Median dose to high risk clinical target volume was 60 Gy/30 fractions. The 5-year locoregional control and overall survival rates were 76% and 57%, respectively. Tumors with >1.5 cm depth of invasion had significantly higher risk of local failure compared with ≤1.5 cm (p<0.001). In multivariate analysis, positive and no neck dissection (p=0.01), positive lymphovascular invasion (p=0.006) and >1.5 cm depth of invasion (p=0.003) were independent predictors of poorer survival. Conclusions Disease outcomes were consistent with historical data and did not appear compromised by the use of IMRT.

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Section: Discussionsupporting

confidence: 92%

Outcomes of oral cavity cancer patients treated with surgery followed by postoperative intensity modulated radiation therapy

et al. 2017

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“…Although these factors are inconsistently reported and their prognostic impact is debatable, they could confound the effect of radiation therapy and chemotherapy on survival. [30][31][32] In addition, use of radiation therapy or chemotherapy could be a surrogate marker for less aggressive resection in very localized disease. This could explain our finding that radiation therapy was associated with a greater decrease in survival in stage I disease than in stage II disease.…”

Section: Discussionmentioning

confidence: 99%

Treatment Factors Associated With Survival in Early-Stage Oral Cavity Cancer

Luryi

Chen

Mehra

et al. 2015

JAMA Otolaryngol Head Neck Surg

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“…Included are surgical margin status (Loree and Strong 1990;Spiro et al 1999;Liao et al 2008), tumor size as part of the TNM system (American Cancer Society 2005), tumor thickness (Clark et al 2006;Fukano et al 1997;Mohit-Tabatai et al 1986;Shah and Lydiatt 1995;Spiro et al 1986), tumor grade (Byers et al 1998), and lymphovascular (Jones et al 2009) and perineural invasion (PNI) (Fagan et al 1998;Soo et al 1986). When analyzed separately, however, each of these factors yielded contradicting conclusions.…”

Section: Introductionmentioning

confidence: 99%