The impact of lymph node dissection and adjuvant chemotherapy on survival: A nationwide cohort study of patients with clinical early-stage ovarian cancer

Kleppe, Marjolein; Aa, Maaike A. van der; Gorp, Toon Van; Slangen, Brigitte; Kruitwagen, Roy F.P.M.

doi:10.1016/j.ejca.2016.07.015

Cited by 50 publications

(49 citation statements)

References 24 publications

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“…In a recent report on lymph node staging in The Netherlands, the incidence of lymph node dissection improved from 26% in 2000 to 67% in 2012. Moreover, the percentage of patients from whom 10 or more lymph nodes were removed also increased during the study period (from 2.3% to 47.6%) [16].…”

Section: Discussionmentioning

confidence: 90%

Incomplete Staging in Ovarian Cancer

Beltman

Laven

Bense

et al. 2020

Preprint

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Objective Incomplete surgical staging of patients with early stage epithelial ovarian cancer (EOC) has been reported in up to 85% of cases, when based on the International Federation of Obstetrics and Gynaecology (FIGO) staging procedure. The aim of the present retrospective study was to clarify the reasons for incomplete staging.Methods The PRISMA (Prevention Recovery Information System for Monitoring and Analysis) technique was used to evaluate cases with FIGO I-IIa EOC based on incomplete staging from five gynecologic oncologic center hospitals in the Netherlands in the period 2010-2014.Results Fifty cases with an incomplete surgical staging of EOC according to national guidelines were included. The most common reasons for incomplete staging were insufficient random biopsies of the peritoneum (n=34, 68%), and less than ten lymph nodes being resected and/or found at pathology (n=16, 32%). The most mentioned reasons for not performing biopsies were forgetting to do so, and believing that after careful inspection and palpation, taking biopsies is irrelevant and/or already are being taken while performing a hysterectomy (cul-de-sac, bladder). The value of contralateral pelvic lymph node dissection in case of a unilateral ovarian malignancy was also doubted, influencing the number of lymph nodes resected.Conclusion The most important reasons for incomplete staging in EOC are, besides omitting elements by accident, questioning the importance of obligatory elements of the staging procedure. A structured list of staging steps during surgery and more evidence based consensus concerning these obligatory elements might increase the number of complete staging procedures in EOC.

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Section: Discussionmentioning

confidence: 90%

Incomplete Staging in Ovarian Cancer

Beltman

Laven

Bense

et al. 2020

Preprint

View full text Add to dashboard Cite

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“…The authors analyzed survival in 3,658 patients with stage I-IIA and IIIA1 ovarian cancer in the Netherlands. In 1,813 (50%) of the cases, LNR was performed and these patients had significantly improved outcome, while patients without LNR, who received adjuvant chemotherapy, had a poorer survival compared to patients with LNR without adjuvant chemotherapy (10).…”

Section: Discussionmentioning

confidence: 99%