The impact of lung cancer resection surgery on fibrinogen and C-reactive protein and their relationship with patients outcomes: A prospective follow up study

Araújo, Amanda Souza; Nogueira, Ingrid Correia; Neto, Antero Gomes; Medeiros, Israel Lopes de; Morano, María Tereza Aguiar Pessoa; Silva, Guilherme; Santos, Flávia Almeida; Filho, Manoel Odorico de Moraes; Pereira, Eanes Delgado Barros

doi:10.3233/cbm-150539

Cited by 8 publications

(7 citation statements)

References 29 publications

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“…Preoperatively, 5 of 6 studies (83%) found an association between depression and inflammatory markers before curative‐intent surgery 25‐28 . Postoperatively, 3 of 4 studies (75%) revealed an association between depressive symptoms and inflammation 29‐32 …”

Section: Resultsmentioning

confidence: 99%

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Cancer‐related inflammation and depressive symptoms: Systematic review and meta‐analysis

McFarland

Doherty

Atkinson

et al. 2022

Cancer

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Background Depressive symptoms in patients with cancer are associated with poor quality of life and decreased survival. Although inflammation is reliably associated with depression in otherwise healthy individuals, the association in patients with cancer remains unclear. Given the high prevalence of cancer‐related inflammation, the authors aimed to establish the relationship between inflammation and depression in cancer patients based on extant literature. Methods A systematic review and meta‐analysis was performed using Preferred Reporting Items for Systematic Reviews and Meta‐Analyses 2020 guidelines and registered under Prospero ID CRD42021226743. Three databases were searched including PubMed, the Cochrane Library, and PsycINFO using the following criteria for inclusion: 1) measurement of a peripheral inflammatory marker, 2) use of a validated tool/scale to measure depression, and 3) a cancer diagnosis. Risk of publication bias was assessed by Funnel plot and Egger test. Results Seventy‐three studies were included in the systematic review and 54 studies (n = 5017) were included in meta‐analyses. Associations with depressive symptoms were significant for peripheral blood interleukin (IL)‐6 (standardized mean difference [SMD] = 0.59; 95% confidence interval [CI], 0.35‐0.82), I2 = 57.9%; tumor necrosis factor (TNF) (SMD = 0.73; 95% CI, 0.35‐1.11), I2 = 74.1%; and C‐reactive protein (CRP) (SMD = 0.57; 95% CI, 0.27‐0.87), I2 = 0%. IL‐5, IL‐13, albumin, and neutrophil‐to‐lymphocyte ratio were associated with depressive symptoms but based on fewer studies. Most cancer settings were represented; the number of studies per inflammatory marker varied from 1 to 52. Conclusions Although peripheral inflammatory markers were unevenly studied, the most studied markers (IL‐6, TNF, and CRP) were associated with depressive symptoms in cancer patients and may be useful for management of depressive symptoms in the cancer setting. Lay Summary Peripheral blood inflammatory markers (IL‐6, TNF, and CRP) were associated with depressive symptoms in various cancer settings. Although further studies are warranted, these findings may help identify and manage depressive symptoms in patients with cancer.

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Section: Resultsmentioning

confidence: 99%

“…Several unique inflammatory markers were reported in single studies. Erythrocyte sedimentation rate (ESR), 36 d‐dimer, 21 and fractaline 57 showed a positive association with depression 21,36 whereas fibrinogen was not associated with depressive symptoms 30 …”

Section: Resultsmentioning

confidence: 99%

Cancer‐related inflammation and depressive symptoms: Systematic review and meta‐analysis

McFarland

Doherty

Atkinson

et al. 2022

Cancer

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“…Hyperfibrinogenemia can exist in many patients with malignant tumors including NSCLC and SCLC, which suggests a poor prognosis. [4,5,7,10,19] Fbg, synthesized by liver, is the highest content of coagulation proteins in plasma and can be converted to fiber polymer (insoluble fibrin) by activated thrombin. It plays a vital role in blood coagulation, fibrinolysis, inflammatory response, wound healing, and tumorigenesis.…”

Section: Discussionmentioning

confidence: 99%

“…[2–4] When diagnosed, most patients have been already in locally advanced or metastatic stages of cancer. [4,5] The blood of cancer patients often stays in hypercoagulable state, especially in the patients with advanced clinicopathological stages (CS). [6–8] Activation of the coagulation system and procoagulant changes have been relevant to angiogenesis, tumor invasion, cancer progression, and distant metastasis.…”

Section: Introductionmentioning

confidence: 99%

The relationship of plasma fibrinogen with clinicopathological stages and tumor markers in patients with non-small cell lung cancer

Bian¹,

Shi

Qi³

et al. 2019

Medicine

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Numerous studies have shown that the blood of cancer patients are generally in hypercoagulable statement. The aim of the present research is to study the relationships of plasma fibrinogen (Fbg) levels with clinicopathological stages (CS) and tumor markers of non-small cell lung cancer (NSCLC). Baseline information, plasma Fbg levels, CS, and expression level of tumor markers were collected from medical records retrospectively. Unitary linear regression was used to analyze the relationships between continuous variables and Fbg, and multiple linear regression was used to analyze the relationships between categorical variables and Fbg. National Comprehensive Cancer Network Clinical Practice Guidelines in Oncology (Version 4) for NSCLC were adopted to evaluate CS. A total of 652 NSCLC patients were included. Compared with the females, male patients had higher mean plasma Fbg levels ( P < .001). The later the N stages ( P = .002), M stages ( P = .002), and CS ( P = .001) were, the higher the average plasma Fbg levels were. The levels of squamous cell carcinoma antigen ( P = .001), carbohydrate antigen 125 ( P = .041), and neuron-specific enolase ( P < .001) were positively correlated with plasma Fbg concentration. The plasma level of Fbg in lung adenocarcinoma patients ( P < .001) was the lowest, while that of lung squamous cell carcinoma patients ( P < .001) was the highest in NSCLC patients. The plasma Fbg concentration is related to gender, CS, and tumor markers in patients with NSCLC.

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“…Few studies have evaluated the association of inflammation and depression at multiple time points (Araujo et al, 2016) or along the cancer treatment trajectory (Chou et al, 2017) and none have evaluated the implications of inflammation and depression at multiple time points on survival. In this study, we hypothesized the following: 1) longitudinal changes in inflammation would correspond to the same direction of changes in depression (i.e., worse inflammation, worse depression); 2) longitudinally elevated inflammation would lead to greater depression over time; and 3) depression with inflammation (at time point 1) would be more persistent than depression without inflammation (measured at time point 2).…”

mentioning

confidence: 99%

A Longitudinal Analysis of Inflammation and Depression in Patients With Metastatic Lung Cancer: Associations With Survival

McFarland

Miller

Nelson

2020

Biological Research For Nursing

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Background: Depression and inflammation are concomitantly elevated in patients with lung cancer and may have collective survival implications. However, the longitudinal relationship between depression and inflammation in patients with metastatic lung cancer is not fully appreciated. We hypothesized that longitudinal changes in inflammation and depression would be concordant; that longitudinally elevated inflammation would lead to greater depression over time; and that depression with inflammation would be more persistent than depression without inflammation. Methods: Patients with metastatic lung cancer (n = 68) were assessed for clinically significant depression (Hospital Anxiety and Depression Scale ≥ 8) and inflammation (C-Reactive Protein ≥ 1 mg/L) along with demographic variables. Survival estimations were made using Cox Proportional Hazard Model and Kaplan-Meier plot analyses. Results: At baseline (T1), 15% had depression and 35% had increased inflammation followed by 18% with depression and 38% with increased inflammation 4.7 months later (T2). The odds ratio of depression in the presence of clinically significant inflammation was 4.8 at T1 and 5.3 at T2. Between time points, inflammation difference correlated with depression difference (r = −.26, p = .03). Significant depression at both time points was associated with a 4 fold risk of inferior survival while significant inflammation at any time point was associated with >3 fold risk of inferior survival. Conclusions: Depression and inflammation track together over time and have variable implications on survival. Persistent depression is particularly detrimental but incidental inflammation is more sensitive to predicting poor survival. These findings have implications for treating depression early in the lung cancer trajectory.

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The impact of lung cancer resection surgery on fibrinogen and C-reactive protein and their relationship with patients outcomes: A prospective follow up study

Abstract: Lung cancer resection surgery was associated with increased level of CRP, 1 month after surgery, and correlated directly with change in fibrinogen and inversely with measurement of performance status. VATS provided lower level of fibrinogen after surgery.

Cited by 8 publications

References 29 publications

Cancer‐related inflammation and depressive symptoms: Systematic review and meta‐analysis

Cancer‐related inflammation and depressive symptoms: Systematic review and meta‐analysis

The relationship of plasma fibrinogen with clinicopathological stages and tumor markers in patients with non-small cell lung cancer

A Longitudinal Analysis of Inflammation and Depression in Patients With Metastatic Lung Cancer: Associations With Survival

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