The impact of lower limb chronic venous disease on quality of life: patient and physician perspectives

Santiago, Fabricio; Ulloa, Jorge H; Régnier, Catherine H.; Peudon, Thibault; Braund, Emilie; Fradet-Aubignat, Claire; Gianesini, Sergio

doi:10.2217/cer-2022-0054

Cited by 5 publications

(12 citation statements)

References 24 publications

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“…The Patient Journey on CVD study was conducted in five countries (Brazil, China, Czech Republic, Italy and Russia) in September/October 2020, and involved 100 patients with CEAP C0 to C4 CVD (20 from each country) and 60 CVD specialists (12 from each country) [ 7 ]. Patients and physicians were identified in each country by local recruiters of a fieldwork agency and their local databases, as such the patients were not necessarily patients of the participating physicians.…”

Section: International Survey On Qol In Cvd Patientsmentioning

confidence: 99%

“…Physicians were asked to rate how they thought CVD affected their patients’ QoL across the same four dimensions on a scale from 1 (very small impact) to 5 (very high impact), and how satisfied they thought patients were with management of their QoL on a scale from 1 (dissatisfied) to 5 (very highly satisfied). In addition, both patients and physicians were asked qualitative questions to gain more insight into how QoL is assessed and the impact of CVD (Table 1 ) [ 7 ].…”

Section: International Survey On Qol In Cvd Patientsmentioning

confidence: 99%

“…In addition, both patients and physicians were asked qualitative questions to gain more insight into how QoL is assessed and the impact of CVD (Table 1 ) [ 7 ].…”

Section: International Survey On Qol In Cvd Patientsmentioning

confidence: 99%

“…The mean ± standard deviation body mass index was 26.2 ± 7.2 kg/m 2 . The majority of patients had been diagnosed 2–5 years previously, and 56% had C2–C3 CVD (18% had C0–C1 and 26% had C4 CVD) [ 7 ]. Overall, 75% of patients were using veno-active drugs.…”

Section: International Survey On Qol In Cvd Patientsmentioning

confidence: 99%

“…The aim of the current review article is to describe the results of a recent study, which examined the QoL in patients with C0 to C4 CVD and the gaps between ways in which physicians and patients viewed the impact of CVD on QoL [ 7 ]. Finally, the article examines the body of evidence regarding the impact of venoactive treatments on the QoL of patients with CVD.…”

Section: Introductionmentioning

confidence: 99%

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Quality of Life in Chronic Venous Disease: Bridging the Gap Between Patients and Physicians

Santiago

2023

Clin Drug Investig

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Chronic venous disease (CVD) has a negative impact on patients’ quality of life (QoL). This was demonstrated in the recent Patient Journey on CVD study, which examined QoL in patients with early- and advanced-stage CVD (Clinical, Etiological, Anatomical and Pathophysiological classification C0 to C4), and the gaps between the way in which physicians and patients viewed the impact of CVD on QoL. The study was conducted in five countries (Brazil, China, Czech Republic, Italy and Russia) and included 100 patients with CVD and 60 CVD specialists. Patients completed the 14-item Chronic Venous Insufficiency Questionnaire (CIVIQ-14) to assess their QoL, and all patients and physicians were questioned during a 60-minute qualitative structured interview, focusing on four key dimensions—physical symptoms, aesthetics/appearance, emotional impact and impact on relationships. The study found that physicians tended to focus more on physical symptoms than on other impacts of CVD and rarely measured QoL in clinical practice. Patients were significantly less satisfied with the management of their QoL than physicians perceived them to be. About 25% of patients with CVD reported disturbed sleep, but physicians did not routinely ask them how CVD affected their sleep. These data reinforce the importance of physicians obtaining information about the impact of CVD on all aspects of the patient’s life, including sleep and QoL. Evidence from randomised controlled trials and real-world studies demonstrates that some veno-active drugs, particularly micronised purified flavonoid fraction, can positively impact QoL in patients with CVD.

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Section: International Survey On Qol In Cvd Patientsmentioning

confidence: 99%

Section: International Survey On Qol In Cvd Patientsmentioning

confidence: 99%

“…In addition, both patients and physicians were asked qualitative questions to gain more insight into how QoL is assessed and the impact of CVD (Table 1 ) [ 7 ].…”

Section: International Survey On Qol In Cvd Patientsmentioning

confidence: 99%

Section: International Survey On Qol In Cvd Patientsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Quality of Life in Chronic Venous Disease: Bridging the Gap Between Patients and Physicians

Santiago

2023

Clin Drug Investig

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VEIN STEP: A Prospective, Observational, International Study to Assess Effectiveness of Conservative Treatments in Chronic Venous Disease

Mezalek,

Feodor,

Chernukha

et al. 2023

Adv Ther

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Introduction VEIN STEP was conducted to collect international data on the management of chronic venous disease (CVD) and to assess the effectiveness of conservative treatments for the relief of CVD signs and symptoms. Methods This international, observational, prospective, longitudinal, cohort study recruited adult outpatients consulting for symptomatic CVD. The primary objective was the effectiveness of conservative treatments on symptoms, signs and quality of life in a real-life setting assessed using a range of patient-reported outcome measures: 10-cm Visual Analog and Patient Global Impression of Change scales for symptoms; Venous Clinical Severity Score for physician assessment of signs; and 14-item ChronIc Venous Insufficiency Questionnaire (CIVIQ-14) for quality of life. At inclusion, patients were prescribed conservative treatment according to the physicians’ usual practice. Follow-up visits took place at weeks 2 and 4, with an optional week 8 visit. Results The analysis set comprised 6084 subjects (78% female) from nine countries with a mean age of 50.6 ± 13.8 years and BMI of 28.0 ± 4.9 kg/m 2 . The most common CEAP classifications were C1 (23.0%), C2 (31.6%), and C3 (30.7%). Conservative therapy consisted of oral venoactive drugs (VADs; 95.8% of subjects) including micronized purified flavonoid fraction (MPFF 75.5%) and diosmin (18.8%), compression (52.0%), and topicals (31.5%). Conservative therapy led to global symptom improvement in 89% of patients after 2 weeks and 96% at 4 weeks. Pain, leg heaviness, cramps, and sensation of swelling were improved in 82%, 71%, 45.5%, and 46% of patients, respectively. Conservative therapy was associated with a decrease over time in patient-assessed global symptom intensity: – 2.37 ± 1.73 ( P < 0.001) and physician-assessed disease severity – 1.83 ± 2.82 ( P < 0.001). Among the VADs, MPFF-based conservative therapy was associated with the greatest reduction in symptom and sign intensity. Improvements in CIVIQ-14 were observed with all treatments but were greatest for MPFF. Conclusion In this prospective study conducted in the real-world setting, treatment with conservative therapy, in particular MPFF, was associated with meaningful improvements in the clinical signs and symptoms of disease as well as in quality of life in patients with CVD. Trial Registration ClinicalTrials.gov identifier NCT04574375. Supplementary Information The online version contains supplementary material available at 10.1007/s12325-023-02643-6.

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Benefits of home-based foot neuromuscular electrical stimulation on self-reported function, leg pain and other leg symptoms among community-dwelling older adults: a sham-controlled randomised clinical trial

Kumaran,

Targett,

Watson

2024

BMC Geriatr

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Introduction Lower leg pain and symptoms, and poor leg circulation are common in older adults. These can significantly affect their function and quality of life. Neuromuscular electrical stimulation (NMES) applied via the feet as ‘foot NMES’ activates the leg musculovenous pump. This study investigated the effects of foot NMES administered at home using Revitive® among community-dwelling older adults with lower leg pain and/or other lower leg symptoms such as cramps, or sensations of tired, aching, and heavy feeling legs. Methods A randomised placebo-controlled study with three groups (2 NMES, 1 Sham) and three assessments (baseline, week 8, week 12 follow-up) was carried out. Self-reported function using Canadian occupational performance measure (COPM), leg pain, overall leg symptoms score (heaviness, tiredness, aching, or cramps), and ankle blood flow were assessed. Analysis of covariance (ANCOVA) and logistic regression were used to compare the groups. Statistical significance was set at p < 0.05 (two-sided 5%). Results Out of 129 participants enrolled, 114 completed the study. The improvement in all outcomes were statistically significant for the NMES interventions compared to Sham at both week 8 (p < 0.01) and week 12 (p < 0.05). The improvement in COPM met the minimal clinically important difference (MCID) for the NMES interventions compared to Sham at both week 8 (p < 0.005) and week 12 (p < 0.05). Improvement in leg pain met MCID at week 8 compared to Sham (p < 0.05). Ankle blood flow increased approximately 3-fold during treatment compared to Sham. Compliance with the interventions was high and no device-related adverse events were reported. Conclusions The home-based foot NMES is safe, and significantly improved self-reported function, leg pain and overall leg symptoms, and increased ankle blood flow compared to a Sham among older adults. Trial registration The trial was prospectively registered in ISRCTN on 17/06/2019 with registration number ISRCTN10576209. It can be accessed at https://www.isrctn.com/ISRCTN10576209.

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The impact of lower limb chronic venous disease on quality of life: patient and physician perspectives

Cited by 5 publications

References 24 publications

Quality of Life in Chronic Venous Disease: Bridging the Gap Between Patients and Physicians

Quality of Life in Chronic Venous Disease: Bridging the Gap Between Patients and Physicians

VEIN STEP: A Prospective, Observational, International Study to Assess Effectiveness of Conservative Treatments in Chronic Venous Disease

Benefits of home-based foot neuromuscular electrical stimulation on self-reported function, leg pain and other leg symptoms among community-dwelling older adults: a sham-controlled randomised clinical trial

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