The impact of low dose busulfan on gonodal function after allogeneic hematopoietic stem cell transplantation for aplastic anemia

Kerbauy, Mariana Nassif; Mariano, Lívia Caroline Barbosa; Seber, Adriana; Rocha, Vanderson

doi:10.1038/s41409-019-0639-5

Cited by 4 publications

(4 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, it is necessary to stratify SAA recipients at risk of developing mixed chimaerism. For those at low risk, potential adverse effects of intensive conditioning regimens could be avoided 20 . Furthermore, a more intensive conditioning regimen will be suggested for those at high risk.…”

Section: Discussionmentioning

confidence: 99%

Mixed chimaerism is associated with poorer long-term failure-free survival among aplastic anaemia patients receiving HLA-matched donor transplantation

Zhang

et al. 2023

Bone Marrow Transplant

View full text Add to dashboard Cite

The aim of this study was to evaluate the adverse effects of mixed chimaerism (MC) on survival outcomes and to assess the ability of different factors to predict MC in severe aplastic anaemia (SAA) patients after HLA-matched donor transplantation. A retrospective study was conducted in 103 consecutive SAA patients who received matched related (MRD) or unrelated donor (MUD) transplantation.The cumulative incidences of mixed chimaerism were 17.8 ± 0.2% and 25.0 ± 0.8% in the MRD and MUD cohorts, respectively (P = 0.432). Patients with mixed chimaerism had signi cantly poorer 10-year failurefree survival (FFS) than those with donor chimaerism (35.0% vs. 87.0%, P < 0.001). A multivariable model identi ed independent adverse predictors of mixed chimaerism, including patient age and ferritin level at transplantation. The incidences of mixed chimaerism were 62.5%, 30.8% and 5.4% in the high-(2 factors), intermediate-(1 factor) and low-risk (0 factor) groups, respectively (P < 0.001). The corresponding FFS rates were 37.5%, 75.3% and 83.6%, respectively (P = 0.018), at the nal follow-up. Therefore, patients with mixed chimaerism suffered poorer long-term FFS, and patients with high-risk scores will be more likely to develop mixed chimaerism. Thus, more intensive conditioning might be recommended for these high-risk patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Mixed chimaerism is associated with poorer long-term failure-free survival among aplastic anaemia patients receiving HLA-matched donor transplantation

Zhang

et al. 2023

Bone Marrow Transplant

View full text Add to dashboard Cite

show abstract

“…Multiple retrospective studies have reported the rates of conception for men after HCT 26, 89-91, 95, 96, 98-100, 102, 104-113 . With one exception 102 all studies consistently showed a low rate of paternity after HCT (See Supplemental Material Table 65). The true prevalence of fertility after HCT is difficult to determine because patients' wishes regarding fatherhood are often unreported in studies.…”

Section: Pregnancy and Fatherhoodmentioning

confidence: 96%

“…Of note, about 4-16% of males already had impairment of spermatogenesis before HCT 25,90 , mostly due to treatment of underlying malignancy. Patients with aplastic anemia, who typically do not require chemotherapy before HCT and receive a reduced intensity regimen as conditioning, frequently show a high rate (50%) of fertility recovery 100,102 . Time after HCT is also an important factor, as one study showed that patients with detectable spermatozoa had longer interval since HCT (>9 years), suggesting a trend to spermatogenesis production with longer follow-up, particularly in patients younger than 25 years at transplantation 91 .…”

Section: Prevalence and Risk Factorsmentioning

confidence: 99%

See 1 more Smart Citation

Male-Specific Late Effects in Adult Hematopoietic Cell Transplantation Recipients: A Systematic Review from the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and Transplant Complications Working Party of the European Society of Blood and Marrow Transplantation

Phelan

Hunter

et al. 2022

Transplantation and Cellular Therapy

View full text Add to dashboard Cite

Male-specific late effects in adult hematopoietic cell transplantation recipients: a systematic review from the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and Transplant Complications Working Party of the European Society of Blood and Marrow Transplantation

Phelan

Hunter

et al. 2022

Bone Marrow Transplant

View full text Add to dashboard Cite

This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

show abstract

The impact of low dose busulfan on gonodal function after allogeneic hematopoietic stem cell transplantation for aplastic anemia

Cited by 4 publications

References 11 publications

Mixed chimaerism is associated with poorer long-term failure-free survival among aplastic anaemia patients receiving HLA-matched donor transplantation

Mixed chimaerism is associated with poorer long-term failure-free survival among aplastic anaemia patients receiving HLA-matched donor transplantation

Contact Info

Product

Resources

About