The impact of levels of particulate matter with an aerodynamic diameter smaller than 2.5 μm on the nasal microbiota in chronic rhinosinusitis and healthy individuals

Padhye, Leena; Kish, Jennifer; Batra, Pete S.; Miller, Gregory E.; Mahdavinia, Mahboobeh

doi:10.1016/j.anai.2020.10.006

Cited by 16 publications

(9 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, another study looked at the impact of only PM 2.5 in both cases and controls 34 . Cases of CRS were associated with higher neighborhood PM 2.5 levels than controls ( p <.001).…”

Section: Resultsmentioning

confidence: 99%

“…On the other hand, another study looked at the impact of only PM 2.5 in both cases and controls. 34 Cases of CRS were associated with higher neighborhood PM 2.5 levels than controls (p <.001). PM 2.5 levels were also associated with eosinophilic markers in CRS patients (p <.01), but no other relationship was noted with other histopathologic markers evaluated.…”

Section: Crs Histopathology and Microbiologymentioning

confidence: 91%

“…A total of 115 articles underwent full-text review, resulting in 10 studies meeting criteria for final data extraction and analysis (Table 1). Of the included studies, three were case-control, 34,36,42 and seven were ecological or cross-sectional. Four studies evaluated incidence or prevalence of CRS.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…PM 2.5 levels were also associated with eosinophilic markers in CRS patients (p <.01), but no other relationship was noted with other histopathologic markers evaluated. Additionally, Padhye et al (2021) assessed for microbial changes associated with air pollution. Interestingly, higher PM 2.5 exposure was associated with relatively lower amounts of Corynebacterium in both CRS and control cases (r = À.197, p = .02).…”

Section: Crs Histopathology and Microbiologymentioning

confidence: 99%

See 3 more Smart Citations

Environmental air pollution and chronic rhinosinusitis: A systematic review

Leland

Vohra

Seal

et al. 2022

Laryngoscope Investig Oto

View full text Add to dashboard Cite

Objective Chronic rhinosinusitis (CRS) is a highly prevalent and burdensome disease. The pathophysiology is not fully elucidated, but environmental pollutants have been suggested to impact the inflammatory component of the disease process. This review aims to summarize the role of environmental pollution in CRS onset and disease severity. Methods A systematic review was performed following Preferred Reporting Items for Systematic Reviews and Meta‐Analyses guidelines. PubMed, EMBASE, Cochrane Library, Web of Science, and Scopus databases were queried in August 2021. Original articles reporting on air pollution exposure in CRS were included. Other forms of sinonasal disease were excluded. Results Literature search produced 11,983 articles, of which 10 met inclusion criteria. Outcomes evaluated included incidence/prevalence, disease severity, quality of life, and histopathologic/microbial changes. Air pollutant exposure was associated with higher odds of CRS, particularly with particulate matter (PM) exposure. Increasing air pollution exposure was also associated with worsened disease severity and detectable histopathologic changes. Impact on quality of life was less clear. Conclusion Air pollution (particularly PM) is correlated with CRS incidence/prevalence and disease severity, with evidence of histopathologic changes in CRS tissue samples. Further research is warranted to better understand the mechanisms by which air pollution components may cause CRS and type 2 inflammation. Level of Evidence 3a

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Crs Histopathology and Microbiologymentioning

confidence: 91%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Crs Histopathology and Microbiologymentioning

confidence: 99%

See 2 more Smart Citations

Environmental air pollution and chronic rhinosinusitis: A systematic review

Leland

Vohra

Seal

et al. 2022

Laryngoscope Investig Oto

View full text Add to dashboard Cite

show abstract

“…20 Another study identified higher levels of average 5-year census-tract PM 2.5 levels in CRS patients than controls, along with decreased nasal microbiota with increased PM 2.5 exposure. 21 The association between PM 2.5 , eosinophilic nasal inflammation, and epithelial barrier dysfunction has also been characterized in mouse models. One study demonstrated claudin-1 and E-cadherin epithelial junction protein dysfunction following 6-week PM 2.5 exposure in mice, as well as elevated pro-inflammatory cytokines in nasal lavage fluid such as IL-1β, IL-13, and eotaxin-1.…”

Section: G R a P H I C A L Abstractmentioning

confidence: 99%

Particulate matter exposure is associated with increased inflammatory cytokines and eosinophils in chronic rhinosinusitis

Lubner,

Rubel,

Chandra

et al. 2024

Allergy

View full text Add to dashboard Cite

BackgroundChronic rhinosinusitis (CRS) is thought to result from complex interactions between the host immune system, microbiota, and environmental exposures. Currently, there is limited data regarding the impact of ambient particulate matter ≤2.5 μm in diameter (PM2.5) in the pathogenesis of CRS, despite evidence linking PM2.5 to other respiratory diseases. We hypothesized that PM2.5 may result in differential cytokine patterns that could inform our mechanistic understanding of the effect of environmental factors on CRS.MethodsWe conducted an analysis of data prospectively collected from 308 CRS patients undergoing endoscopic sinus surgery. Cytokines were quantified in intraoperative mucus specimens using a multiplex flow cytometric bead assay. Clinical and demographic data including zip codes were extracted and used to obtain tract‐level income and rurality measures. A spatiotemporal machine learning model was used to estimate daily PM2.5 levels for the year prior to each patient's surgery date. Spearman correlations and regression analysis were performed to characterize the relationship between mucus cytokines and PM2.5.ResultsSeveral inflammatory cytokines including IL‐2, IL‐5/IL‐13, IL‐12, and 21 were significantly correlated with estimated average 6, 9, and 12‐month preoperative PM2.5 levels. These relationships were maintained for most cytokines after adjusting for age, income, body mass index, rurality, polyps, asthma, and allergic rhinitis (AR) (p < .05). There were also higher odds of asthma (OR = 1.5, p = .01) and AR (OR = 1.48, p = .03) with increasing 12‐month PM2.5 exposure. Higher tissue eosinophil counts were associated with increasing PM2.5 levels across multiple timeframes (p < .05).ConclusionsChronic PM2.5 exposure may be an independent risk factor for development of a mixed, type‐2 dominant CRS inflammatory response.

show abstract