The Impact of LEP rs7799039 Polymorphism and Obesity on the Severity of Coronavirus Disease-19

Mohamed, Amal Ahmed; Alrohaimi, Abdulmohsen H; Abdelgeliel, Asmaa Sayed; Albogami, Sarah; Jafri, Ibrahim; Fayad, Eman; Mohamed, Nouran; Nassar, Nourelhuda Ahmed; Adaroas, Ahmad Sobhy; Eldeeb, Hala H; Halim, Ahmed Abdel; Ramadan, Ahmed; Elnagar, Rehab M; Abdelghafour, Reem A; Mohamed, Amira Yones; Mahmoud, Maha O; El-Kasses, Ahmed; Elsayed, Mohamed; Mohammed, M.; Alwaleed, Eman A.; Mousa, Shrook; Salam, Sherief Abdel; Salam, Soha Mahmoud Abd El

doi:10.2147/dmso.s391869

Cited by 2 publications

(1 citation statement)

References 41 publications

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“…This finding offers both an interesting target for nutrigenetic management and a mechanistic understanding of weight gain and loss in light of the central regulation of appetite. In addition, the rs4343 in the leptin gene, previously associated with weight gain and satiety (62,63), was a novel finding related to weight loss in patients undergoing these procedures.…”

Section: Discussionmentioning

confidence: 98%

Genetic variant panel allows predicting both obesity risk, and efficacy of procedures and diet in weight loss

Mera-Charria,

Nieto-Lopez,

Francès

et al. 2023

Front. Nutr.

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PurposeObesity is a multifactorial condition with a relevant genetic correlation. Recent advances in genomic research have identified several single nucleotide polymorphisms (SNPs) in genes such as FTO, MCM6, HLA, and MC4R, associated with obesity. This study aimed to evaluate the association of 102 SNPs with BMI and weight loss treatment response in a multi-ethnic population.MethodsThe study analyzed 9,372 patients for the correlation between SNPs and BMI (dataset A). The correlation between SNP and weight loss was accessed in 474 patients undergoing different treatments (dataset B). Patients in dataset B were further divided into 3 categories based on the type of intervention: dietary therapy, intragastric balloon procedures, or surgeries. SNP association analysis and multiple models of inheritance were performed.ResultsIn dataset A, ten SNPs, including rs9939609 (FTO), rs4988235 (MCM6), and rs2395182 (HLA), were significantly associated with increased BMI. Additionally, other four SNPs, rs7903146 (TCF7L2), (rs6511720), rs5400 (SLC2A2), and rs7498665 (SH2B1), showed sex-specific correlation. For dataset B, SNPs rs2016520 (PPAR-Delta) and rs2419621 (ACSL5) demonstrated significant correlation with weight loss for all treatment types. In patients who adhered to dietary therapy, SNPs rs6544713 (ABCG8) and rs762551 (CYP1A2) were strongly correlated with weight loss. Patients undergoing surgical or endoscopic procedures exhibited differential correlations with several SNPs, including rs1801725 (CASR) and rs12970134 (MC4R), and weight loss.ConclusionThis study provides valuable insights into the genetic factors influencing BMI and weight loss response to different treatments. The findings highlight the potential for personalized weight management approaches based on individual genetic profiles.

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Section: Discussionmentioning

confidence: 98%

Genetic variant panel allows predicting both obesity risk, and efficacy of procedures and diet in weight loss

Mera-Charria,

Nieto-Lopez,

Francès

et al. 2023

Front. Nutr.

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The influence of nutritional status, lipid profile, leptin concentration and polymorphism of genes encoding leptin and neuropeptide Y on the effectiveness of immunotherapy in advanced NSCLC patients

Frąk,

Grenda,

Krawczyk

et al. 2024

BMC Cancer

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Introduction Neuropeptide Y is a neurotransmitter in the nervous system and belongs to the orexigenic system that increases appetite. Its excessive secretion leads to obesity. Leptin is a pro-inflammatory adipokine (produced in adipose tissue) induced in obesity and may mediate increased antitumor immunity in obesity (including the promotion of M1 macrophages). Leptin and neuropeptide Y gene polymorphisms, causing increased leptin levels and the occurrence of obesity, and lipid profile disorders, may increase the effectiveness of immunotherapy. Materials and methods In 121 patients with advanced NSCLC without mutations in the EGFR gene and rearrangements of the ALK and ROS1 genes, undergoing immunotherapy (1st and 2nd line of treatment) or chemoimmunotherapy (1st line of treatment), we assessed BMI, lipid profile, PD-L1 expression on cancer cells using the immunohistochemical method (clone SP263 antibody), leptin concentration in blood serum by ELISA, polymorphisms in the promoter region of the genes for leptin ( LEP ) and neuropeptide Y ( NPY ) by real-time PCR. Results Leptin concentration was significantly higher in obese patients than in patients with normal or low weight ( p = 0.00003) and in patients with disease stabilization compared to patients with progression observed during immunotherapy ( p = 0.012). Disease control occurred significantly more often in patients with the GA or AA genotype than patients with the GG genotype in the rs779039 polymorphism of the LEP gene. The median PFS in the entire study group was five months (95% CI: 3-5.5), and the median OS was 12 months (95% CI: 8–16). Median PFS was highest in patients with TPS ≥ 50% (6.5 months) and in obese patients (6.6 months). Obese patients also had a slightly longer median OS compared to other patients (23.8 vs. 13 months). The multivariate Cox logistic regression test showed that the only factor reducing the risk of progression was TPS ≥ 50% (HR = 0.6068, 95% CI: 0.4001–0.9204, p = 0, 0187), and the only factor reducing the risk of death was high leptin concentration (HR = 0.6743, 95% CI: 0.4243–1.0715, p = 0.0953). Conclusion Assessment of nutritional status, serum leptin concentration and polymorphisms in the LEP gene may be of additional importance in predicting the effectiveness of immunotherapy and chemoimmunotherapy in patients with advanced NSCLC.

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The Impact of LEP rs7799039 Polymorphism and Obesity on the Severity of Coronavirus Disease-19

Cited by 2 publications

References 41 publications

Genetic variant panel allows predicting both obesity risk, and efficacy of procedures and diet in weight loss

Genetic variant panel allows predicting both obesity risk, and efficacy of procedures and diet in weight loss

The influence of nutritional status, lipid profile, leptin concentration and polymorphism of genes encoding leptin and neuropeptide Y on the effectiveness of immunotherapy in advanced NSCLC patients

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