The impact of leishmaniasis on mental health and psychosocial well-being: A systematic review

Pires, Malini; Wright, Barry; Kaye, Paul M.; Conceição, Virgínia da; Churchill, Rachel

doi:10.1371/journal.pone.0223313

Cited by 48 publications

(29 citation statements)

References 69 publications

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“… 3 Physical impairments and disfigurements, primarily observed in the dermatological presentations of CL and PKDL, lead to stigmatization, discrimination and ultimately psychosocial impact ( Figure 1 ). 38 …”

Section: Psychosocial Impacts Of the Leishmaniasesmentioning

confidence: 99%

Vulnerabilities to and the Socioeconomic and Psychosocial Impacts of the Leishmaniases: A Review

Grifferty¹,

Shirley²,

McGloin

et al. 2021

RRTM

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The leishmaniases are a group of four vector-borne neglected tropical diseases (NTDs) with 1.6 billion people in some 100 countries at risk. They occur in certain eco-epidemiological foci that reflect manipulation by human activities, such as migration, urbanization and deforestation, of which poverty, conflict and climate change are key drivers. Given their synergistic impacts, risk factors and the vulnerabilities of poor populations and the launch of a new 2030 roadmap for NTDs in the context of the global sustainability agenda, it is warranted to update the state of knowledge of the leishmaniases and their effects. Using existing literature, we review socioeconomic and psychosocial impacts of leishmaniasis within a framework of risk factors and vulnerabilities to help inform policy interventions. Studies show that poverty is an overarching primary risk factor. Low-income status fosters inadequate housing, malnutrition and lack of sanitation, which create and exacerbate complexities in access to care and treatment outcomes as well as education and awareness. The co-occurrence of the leishmaniases with malnutrition and HIV infection further complicate diagnosis and treatment, leading to poor diagnostic outcomes and therapeutic response. Even with free treatment, households may suffer catastrophic health expenditure from direct and indirect medical costs, which compounds existing financial strain in low-income communities for households and healthcare systems. The dermatological presentations of the leishmaniases may result in long-term severe disfigurement, leading to stigmatization, reduced quality of life, discrimination and mental health issues. A substantial amount of recent literature points to the vulnerability pathways and burden of leishmaniasis on women, in particular, who disproportionately suffer from these impacts. These emerging foci demonstrate a need for continued international efforts to address key risk factors and population vulnerabilities if leishmaniasis control, and ultimately elimination, is to be achieved by 2030.

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Section: Psychosocial Impacts Of the Leishmaniasesmentioning

confidence: 99%

Vulnerabilities to and the Socioeconomic and Psychosocial Impacts of the Leishmaniases: A Review

Grifferty¹,

Shirley²,

McGloin

et al. 2021

RRTM

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“…Collectively, the tegumentary forms of leishmaniasis account for approximately two-thirds of the global disease burden, while VL accounts for most reported deaths 1,6 . In addition to the impact of primary disease, recent studies have also emphasized the importance of considering the long term sequelae of leishmaniasis, notably those associated with stigmatization, when evaluating global burden of these diseases [9][10][11] .…”

mentioning

confidence: 99%

Characterization of a new Leishmania major strain for use in a controlled human infection model

et al. 2021

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Leishmaniasis is widely regarded as a vaccine-preventable disease, but the costs required to reach pivotal Phase 3 studies and uncertainty about which candidate vaccines should be progressed into human studies significantly limits progress in vaccine development for this neglected tropical disease. Controlled human infection models (CHIMs) provide a pathway for accelerating vaccine development and to more fully understand disease pathogenesis and correlates of protection. Here, we describe the isolation, characterization and GMP manufacture of a new clinical strain of Leishmania major. Two fresh strains of L. major from Israel were initially compared by genome sequencing, in vivo infectivity and drug sensitivity in mice, and development and transmission competence in sand flies, allowing one to be selected for GMP production. This study addresses a major roadblock in the development of vaccines for leishmaniasis, providing a key resource for CHIM studies of sand fly transmitted cutaneous leishmaniasis.

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“…Collectively, the tegumentary forms of leishmaniasis account for approximately two-thirds of the global disease burden, whilst VL accounts for most reported deaths 1 . In addition to the impact of primary disease, recent studies have also emphasized the importance of considering the long term sequelae of leishmaniasis, notably those associated with stigmatization, when evaluating global burden of these diseases 8–10 .…”

Section: Introductionmentioning

confidence: 99%

Characterization of a newLeishmania majorisolate for use in a controlled human infection model

Ashwin

Sádlová

Vojtková

et al. 2020

Preprint

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Leishmaniasis is widely regarded as a vaccine-preventable disease, but the costs required to reach pivotal Phase 3 studies and uncertainty about which candidate vaccines should be progressed into human studies significantly limits progress in vaccine development for this neglected tropical disease. Controlled human infection models (CHIM) provide a pathway for accelerating vaccine development and to more fully understand disease pathogenesis and correlates of protection. Here, we describe the isolation, characterization and GMP manufacture of a new clinical isolate of Leishmania major. Two fresh isolates of L. major from Israel were initially compared by genome sequencing, in vivo infectivity and drug sensitivity in mice, and development and transmission competence in sand flies, allowing one (L. major_MRC-02) to be selected for GMP production. This study addresses a major roadblock in the development of vaccines for leishmaniasis, providing a key resource for CHIM studies of sand fly transmitted cutaneous leishmaniasis.

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The impact of leishmaniasis on mental health and psychosocial well-being: A systematic review

Cited by 48 publications

References 69 publications

Vulnerabilities to and the Socioeconomic and Psychosocial Impacts of the Leishmaniases: A Review

Vulnerabilities to and the Socioeconomic and Psychosocial Impacts of the Leishmaniases: A Review

Characterization of a new Leishmania major strain for use in a controlled human infection model

Characterization of a newLeishmania majorisolate for use in a controlled human infection model

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