The impact of KIR2DS4 alleles and the expression of KIR in the development of acute GVHD after unrelated allogeneic hematopoietic SCT

Bao, Xiaojing; Hou, Lihua; Sun, Aining; Qiu, Qiao‐Cheng; Yuan, Xin; Chen, M H; Chen, Z X; He, Jun

doi:10.1038/bmt.2009.357

Cited by 26 publications

(19 citation statements)

References 38 publications

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“…KIR2DS4 is functional, as shown using transfectants and primary NK cells [65]. In genetic studies, associations with malaria, leukemia, and acute graft-versus-host disease (GvHD) are described [103][104][105][106]. All these recent findings indicate that KIR2DS4 needs to be considered when KIRs on NK cells interact with HLA-C molecules in disease and pregnancy.…”

Section: Kir2ds4mentioning

confidence: 96%

Maternal KIR and fetal HLA-C: a fine balance

Chazara

Xiong

Moffett

2011

Journal of Leukocyte Biology

151

138

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NK cell effector function is regulated by a range of activating and inhibitory receptors, and many of their known ligands are MHC class I molecules. Human NK receptors encoded by the Killer immunoglobulin-like receptor (KIR) gene family recognize polymorphic HLA-C as well as some HLA-A and HLA-B molecules. KIRs are expressed by uterine NK (uNK) cells, which are distinctive NK cells directly in contact with the invading fetal placental cells that transform the uterine arteries during the first trimester. Trophoblast cells express both maternal and paternal HLA-C allotypes and can therefore potentially interact with KIRs expressed by uNK. Therefore, allorecognition of paternal HLA-C by maternal KIR might influence trophoblast invasion and vascular remodeling, with subsequent effects on placental development and the outcome of pregnancy. We discuss here the studies relating to KIR/HLA-C interactions with an emphasis on how these function during pregnancy to regulate placentation.

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Section: Kir2ds4mentioning

confidence: 96%

Maternal KIR and fetal HLA-C: a fine balance

Chazara

Xiong

Moffett

2011

Journal of Leukocyte Biology

151

138

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“…In another study, the presence of the KIR2DS4*003 allele (del), together with KIR2DS2, was correlated with the development of acute graft versus host disease (GVHD) (34). In another study, the presence of genotype A/A and both the full-length KIR2DS4*00101 allele in the donor HSCT was also associated with an increased risk of GVHD (35). According to the authors, the presence of two KIR2DS4-full alleles in a donor can lead to further activation of NK cells with the subsequent secretion of INF-gamma activation of dendritic cells and an influence on GVHD.…”

Section: Distribution Of Frequencies Of Kir2ds4 Full-length and Kir2dmentioning

confidence: 98%

Investigation of Deletion of 22pb in KIR2DS4 Gene in a Population of Southern Brazil

Marangon

Visentainer

Guelsin

et al. 2014

Clinical Laboratory Analysis

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“…HSCT has been also reported previously [31]. There is one important difference when comparing the unrelated or haploidentical and sibling donor transplant procedures and that is in the dose of donor T cells that are administered at the time of transplantation because unrelated grafts are more aggressively T-cell depleted.…”

Section: Kir Hla*c Ligandsmentioning

confidence: 99%

Association of Killer Cell Immunoglobulin-Like Receptor Genes with the Graft versus Host Disease after Related Haematopoietic Stem Cell Transplantation in Patients with Haematological Malignancies from Republic of Macedonia

et al. 2012

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Aim: The aim of this study was to examine the gene frequencies of 16 KIR genes and pseudogenes and KIR genotypes in Macedonian patients with transplanted bone marrow and their sibling donors in treatment of haematological malignancy, and to analyse eventual association of the gene content with the occurrence of a graft versus host disease (GVHD). Material and Methods:The study was performed on 24 patients and their HLA-matched sibling donors. Results:Comparison of KIR gene frequencies between the total 24 donors and healthy Macedonians reveals statistically significant difference for KIR2DS1 (F= 0.481 in the controls group, and 0.76 in the patients group, p=0.004). This significance is even higher when the frequency of KIR2DS1 in controls is compared with the frequency in donors from pairs with GVHD (F= 0.923, P= 0.002). Another significant difference was observed for the frequency of the full-length allele of KIR2DS4*001-002, present in 25.2% of the control individuals, but in as much as 81.8% of the recipients of haematopoietic stem cell (P=0.0005). We did not see any statistically significant difference in distribution of the C1/C1, C1/C2 and C2/C2 groups among GVHD pairs. Conclusion:Our results address the difference between the haematopoietic stem cell transplantation settings with sibling and unrelated donors and suggest that the KIR2DS4*001/002 might be a predisposing factor for severe GVHD in sibling HSCT.

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The impact of KIR2DS4 alleles and the expression of KIR in the development of acute GVHD after unrelated allogeneic hematopoietic SCT

Cited by 26 publications

References 38 publications

Maternal KIR and fetal HLA-C: a fine balance

Maternal KIR and fetal HLA-C: a fine balance

Investigation of Deletion of 22pb in KIR2DS4 Gene in a Population of Southern Brazil

Association of Killer Cell Immunoglobulin-Like Receptor Genes with the Graft versus Host Disease after Related Haematopoietic Stem Cell Transplantation in Patients with Haematological Malignancies from Republic of Macedonia

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