The Impact of  Kinase Insert Domain (KDR) Gene Polymorphism rs2305948 on Clopidogrel Resistance in Iraqi Patients Undergoing Elective Percutaneous Coronary Intervention (PCI)

Ahmed, Ali; Amber, Khalid; Hadi, Najah R

doi:10.5455/aim.2020.28.202-208

Cited by 2 publications

(2 citation statements)

References 37 publications

(21 reference statements)

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“…Stroke or myocardial infarction will occur if the plaque becomes unstable and ruptures. Currently, CHD is the global leading cause of death and results in 18 million deaths per year (Ahmed et al, 2020 ). Percutaneous coronary intervention (PCI) is a minimally invasive procedure and is recommended for subacute and acute coronary heart disease, including all ST‐elevation myocardial infarction (STEMI) (Lee et al, 2021 ; Silalahi et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

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Influencing factors of care dependence in patients with coronary heart disease after percutaneous coronary intervention—A cross‐sectional study

et al. 2022

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Aim Care dependence has been scarcely investigated in coronary heart disease patients after percutaneous coronary intervention. This study aimed to investigate the association between frailty, self‐efficacy, combined effects of frailty and self‐efficacy, mental health, and care dependence in coronary heart disease patients after percutaneous coronary intervention. Design Cross‐sectional study. Methods Data from 400 patients after percutaneous coronary intervention were collected from 2017–2020. Logistic regression model and mediating analysis were used to identify the association between frailty, self‐efficacy, combined effects of frailty and self‐efficacy, and care dependence. Results Patients with frailty and self‐efficacy tended to have severe care dependence symptoms. There was no correlation between frailty symptoms, self‐efficacy, and care dependence in patients without symptoms of anxiety or depression. But in patients with anxiety or depression symptoms, there is a strong correlation between frailty symptoms, lower self‐efficacy, and care dependence. Mental health played an inhibitory effect on frailty and care dependence.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Influencing factors of care dependence in patients with coronary heart disease after percutaneous coronary intervention—A cross‐sectional study

et al. 2022

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Associations of <i>VEGFR2</i> rs2305948 polymorphism with long-term prognosis of myocardial infarction

Vorobyov,

Lifshits,

Zelenskaya

et al. 2024

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Aim. To evaluate the associations of VEGFR2 rs2305948 polymorphism with the occurrence of cardiovascular events during long-term follow-up in patients with myocardial infarction. Material and methods. The study included 218 patients with acute infarction (MI), mean age 57.7 ± 9.9 years (M ± SD). After clinical examination and preparation, patients urgently underwent coronary angiography followed by percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG). All patients underwent determination of the rs2305948 VEGFR2 allelic variant by polymerase chain reaction. The duration of long-term follow-up of these patients was 9 years (from 2015 to 2024). Results. It was determined that during long-term follow-up, patients with rs2305948 VEGFR (C/T and T/T), in contrast to patients with rs2305948 VEGFR (C/C), were more likely to experience cardiovascular death, recurrent acute coronary syndrome (ACS), recurrent revascularization and a combined end point (cardiovascular death, recurrent ACS, coronary stent/bypass thrombosis, acute ischemic cerebrovascular accident, repeated myocardial revascularization). Using multivariate analysis, it was determined that the occurrence of cardiovascular death during long-term follow-up is directly influenced by the Charlton comorbidity index (p < 0.001) and rs2305948 VEGFR2 (C/T and T/T) (p = 0.030). The onset of a combined endpoint is directly determined by the Charlton comorbidity index (p = 0.014) and rs2305948 VEGFR2 (C/T and T/T) (p = 0.034) and vice versa by subsequent outpatient treatment with high doses of statins (p < 0.001). Conclusions. The presence of rs2305948 VEGFR (C/T and T/T) in patients with MI increases the likelihood of cardiovascular death by 2.82 times and the combined endpoint by 2.10 times during long-term follow-up (9 years).

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The Impact of Kinase Insert Domain (KDR) Gene Polymorphism rs2305948 on Clopidogrel Resistance in Iraqi Patients Undergoing Elective Percutaneous Coronary Intervention (PCI)

Cited by 2 publications

References 37 publications

Influencing factors of care dependence in patients with coronary heart disease after percutaneous coronary intervention—A cross‐sectional study

Influencing factors of care dependence in patients with coronary heart disease after percutaneous coronary intervention—A cross‐sectional study

Associations of <i>VEGFR2</i> rs2305948 polymorphism with long-term prognosis of myocardial infarction

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