The impact of irritable bowel syndrome on health-related quality of life

Gralnek, Ian M.; Hays, Ron D.; Kilbourne, Amy M.; Naliboff, Bruce D.; Mayer, Emeran A.

doi:10.1053/gast.2000.16484

Cited by 645 publications

(542 citation statements)

References 34 publications

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“…13,14 The origin and development of IBS are unclear and genetic, neurobiological and psychosocial factors seem to be involved in the pathogenesis of the disease. 15 Furthermore, IBS appears to result from an interplay between susceptibility genes and impaired gut barrier functions, immunologic dysregulation, as well as bacterial and viral infections and other environmental factors.…”

Section: Discussionmentioning

confidence: 99%

A Cytologic Assay for Diagnosis of Food Hypersensitivity in Patients With Irritable Bowel Syndrome

Carroccio

Brusca

Mansueto

et al. 2010

Clinical Gastroenterology and Hepatology

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Section: Discussionmentioning

confidence: 99%

A Cytologic Assay for Diagnosis of Food Hypersensitivity in Patients With Irritable Bowel Syndrome

Carroccio

Brusca

Mansueto

et al. 2010

Clinical Gastroenterology and Hepatology

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“…However, IBS considerably reduces quality of life to the same degree of impairment as major chronic diseases, including diabetes, congestive heart failure, renal insufficiency and hepatic cirrhosis (17)(18)(19)(20)(21). Besides the increased morbidity caused by IBS, the syndrome is an economic burden to society in varying forms, for example by increasing the incidence of sick leave and the over-consumption of healthcare resources (1).…”

Section: Introductionmentioning

confidence: 99%

Low-grade inflammation in the rectum of patients with sporadic irritable bowel syndrome

Gundersen¹,

Hatlebakk

Hausken

2013

Molecular Medicine Reports

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Abstract. Irritable bowel syndrome (IBS) is a common chronic gastrointestinal disorder that considerably reduces quality of life and is an economic burden on society. The pathogenesis of IBS is unknown. However, intestinal low-grade inflammation has been proposed as one of the factors contributing to the development of IBS. The present study aimed to examine the possible occurrence of low-grade inflammation in the rectum of patients with sporadic IBS. In total, 50 patients (42 females and 8 males with an average age of 34 years) with sporadic IBS fulfilling the Rome III Criteria were recruited for this study. Of these, 30 patients had IBS with diarrhoea as the predominant symptom (IBS-D) and 20 patients had IBS with constipation as the predominant symptom (IBS-C). A total of 27 control subjects (19 females and 8 males with an average age of 53 years) were included. The patients and controls underwent colonoscopy with rectal biopsies. The biopsies were immunostained for total leucocytes, lymphocytes, monocytes, macrophages and mast cells. The mucosal density of these cells was quantified by computer image analysis. The number of intraepithelial leucocytes and the density of the leucocytes in the lamina propria of the IBS patients did not differ from that of the controls. Similarly, there was no difference in the cell density of the mast cells in the lamina propria between the patients and the controls. The numbers of mucosal lymphocytes, macrophages and monocytes were low in the patients and the controls. These findings oppose low-grade inflammation as a pathogenic factor in sporadic IBS. Low-grade inflammation may, however, play an important role in the pathogenesis of a subset of IBS, namely post-infectious IBS (PI-IBS).

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“…Also frequently associated are psychiatric disorders including major depression, anxiety and somatoform disorders 43 . These comorbidities are linked with a greater need to seek medical attention, a worse prognosis, and a higher rate of anxiety and depression, all of which contribute to a reduced quality of life 44 .…”

Section: Clinical Manifestationsmentioning

confidence: 99%

Irritable bowel syndrome - from etiopathogenesis to therapy

Radovanović-Dinić¹,

Tešić-Rajković²,

Grgov³

et al. 2018

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Irritable bowel syndrome (IBS) is a chronic and relapsing functional gastrointestinal disorder that affects 9-23% of the population across the world. Patients with IBS are often referred to gastroenterology, undergo various investigations, take various medicines, take time off work and have a poor quality of life. The pathophysiology of IBS is not yet completely understood and seems to be multifactorial. Many pathogenetic factors, in various combinations, and not all necessarily present in each patient, can play an important role. Discomfort or abdominal pain relieived by defacation, asociated with a change in stool form, is a typical clinical manifestation of IBS. Many factors, such as emotional stress and eating, may exacerbate the symptoms. A timely diagnosis of IBS is important so that treatment which will provide adequate symptomatic relief (diarrhoea, constipation, pain and boaring) can be introduced. The diagnosis of IBS is not confirmed by a specific test or structural abnormality. It is made using criteria based on clinical symptoms such as Rome criteria, unless the symptoms are thought to be atypical. Today the Rome Criteria IV is the current gold-standard for the diagnoses of IBS. Treatment of patients with IBS requires a multidisciplinary approach. Some patients respond well to non-pharmacological treatment, while others also require pharmacological treatment. This review will provide a summary of pathophysiology, diagnostic criteria and therapies for IBS.

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The impact of irritable bowel syndrome on health-related quality of life

Cited by 645 publications

References 34 publications

A Cytologic Assay for Diagnosis of Food Hypersensitivity in Patients With Irritable Bowel Syndrome

A Cytologic Assay for Diagnosis of Food Hypersensitivity in Patients With Irritable Bowel Syndrome

Low-grade inflammation in the rectum of patients with sporadic irritable bowel syndrome

Irritable bowel syndrome - from etiopathogenesis to therapy

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