The impact of indoor residual spraying of deltamethrin on dengue vector populations in the Peruvian Amazon

Paredes-Esquivel, Claudia; Lenhart, Audrey; Río, R. Del; Leza, Mar; Estrugo, M.; Chalco, Enrique; Casanova, Wilma; Miranda, Miguel Ángel

doi:10.1016/j.actatropica.2015.10.020

Cited by 44 publications

(65 citation statements)

References 19 publications

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“…aegypti strains up to eight weeks post spraying but mortality was reduced to 55% at 16 weeks post-spraying [29]. Thus, we designed our post-intervention (PI) entomological evaluations to occur at 15 days, 1 month, 2 months and 3 months post-spraying.…”

Section: Methodsmentioning

confidence: 99%

Deltamethrin resistance in Aedes aegypti results in treatment failure in Merida, Mexico

et al. 2017

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The operational impact of deltamethrin resistance on the efficacy of indoor insecticide applications to control Aedes aegypti was evaluated in Merida, Mexico. A randomized controlled trial quantified the efficacy of indoor residual spraying (IRS) against adult Ae. aegypti in houses treated with either deltamethrin (to which local Ae. aegypti expressed a high degree of resistance) or bendiocarb (to which local Ae. aegypti were fully susceptible) as compared to untreated control houses. All adult Ae. aegypti infestation indices during 3 months post-spraying were significantly lower in houses treated with bendiocarb compared to untreated houses (odds ratio <0.75; incidence rate ratio < 0.65) whereas no statistically significant difference was detected between the untreated and the deltamethrin-treated houses. On average, bendiocarb spraying reduced Ae. aegypti abundance by 60% during a 3-month period. Results demonstrate that vector control efficacy can be significantly compromised when the insecticide resistance status of Ae. aegypti populations is not taken into consideration.

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Section: Methodsmentioning

confidence: 99%

Deltamethrin resistance in Aedes aegypti results in treatment failure in Merida, Mexico

et al. 2017

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“…Mosquitoes transmit a lot of pathogens, causing severe diseases such as malaria, dengue fever, West Nile fever, encephalitis, and filariasis, which threat public health worldwide (Andriessen et al 2015, Fortuna et al 2015, Paredes-Esquivel et al 2015. Recent estimates show that there are about 400 million infections of dengue fever annually around the world (Sood et al 2015).…”

Section: Introductionmentioning

confidence: 99%

“…In addition, knockdown of CpCPR5 decreased the sensitivity of mosquitoes to deltamethrin in the DS-strain. In conclusion, our study finds a molecular link between miR-932 and CpCPR5 and provides a novel insight into the mechanism of insecticide resistance.Key words: Culex pipiens pallens, pyrethroid, microRNA, CpCPR5Mosquitoes transmit a lot of pathogens, causing severe diseases such as malaria, dengue fever, West Nile fever, encephalitis, and filariasis, which threat public health worldwide (Andriessen et al 2015, Fortuna et al 2015, Paredes-Esquivel et al 2015. Recent estimates show that there are about 400 million infections of dengue fever annually around the world (Sood et al 2015).…”

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confidence: 99%

MiR-932 Regulates Pyrethroid Resistance inCulex pipiens pallens(Diptera: Culicidae)

Liu¹,

Tian²,

Guo³

et al. 2016

J Med Entomol

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MicroRNAs (miRNAs) play notable role in regulation of gene expression at the posttranscription level, and have been involved in many biological processes, including insecticide resistance. In this study, we investigated the role of miR-932 in the molecular mechanisms of pyrethroid resistance in Culex pipiens pallens (L.). Overexpression of miR-932 in the DS-strain made the mosquitoes more resistant to deltamethrin, while inhibiting the expression of miR-932 in the DR-strain made the mosquitoes more sensitive to deltamethrin. Further, we also identified CpCPR5 as a target gene of miR-932. Sustained overexpression of miR-932 resulted in repression of CpCPR5, and that knockdown of miR-932 increased CpCPR5 expression. In addition, knockdown of CpCPR5 decreased the sensitivity of mosquitoes to deltamethrin in the DS-strain. In conclusion, our study finds a molecular link between miR-932 and CpCPR5 and provides a novel insight into the mechanism of insecticide resistance.Key words: Culex pipiens pallens, pyrethroid, microRNA, CpCPR5Mosquitoes transmit a lot of pathogens, causing severe diseases such as malaria, dengue fever, West Nile fever, encephalitis, and filariasis, which threat public health worldwide (Andriessen et al. 2015, Fortuna et al. 2015, Paredes-Esquivel et al. 2015. Recent estimates show that there are about 400 million infections of dengue fever annually around the world (Sood et al. 2015). According to the WHO world malaria report, there are still 214 million new infections worldwide in 2015. Therefore, it is imperative for controlling and preventing mosquito-borne diseases. However, due to the lack of effective vaccines and drugs, vector control mostly relies on insecticides to reduce the number of mosquitoes (Glunt et al. 2015). But continuous and lasting application of insecticides has led to a constant increasing resistance, which makes antivector strategies more challenging (Rasic et al. 2015). Insecticide resistance arises from complex polygenic inheritance and many genes involved , Bonizzoni et al. 2015. These genes can be regulated at transcriptional and posttranscriptional levels and microRNA (miRNA) is known to be a posttranscriptional gene regulator (Wang et al. 2016).MiRNA is a class of small noncoding RNA, with about 22 nucleotides in length. It has been shown to repress translation via imperfectly pairing with complementary sites within the 3'UTR of target mRNA (Liu et al. 2014, Munoz et al. 2015. In diverse cellular programs, miRNA plays a key role and involves in cell growth, differentiation, apoptosis, and many other physiological processes , Park et al. 2015. In insects, the studies on miRNAs are mostly focused on the development, behavior, and hostpathogen interactions (Lucas et al. 2015). Recent evidence has shown that a few miRNAs participate in the regulation of insecticide resistance in mosquitoes, but the exact role of miRNA in pyrethroid resistance is still under little attention yet .Here, according to our previous study, we identified many different expressed miRNAs...

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“…Where DDT is still used it is applied not to crops but to the inside walls of houses to kill or repel mosquitoes, a practice now approved by the WHO in regions where malaria and dengue are of profound concern to public health. This intervention, called indoor residual spraying (IRS), greatly reduces environmental damage and the incidence of resistance to DDT and other pesticides used [50,51].…”

Section: J Infect Dis Patholmentioning

confidence: 99%

Vector Control Interventions to Prevent Dengue: Current Situation and Strategies for Future Improvements to Management of Aedes in India

Singh¹,

Taylor‐Robinson²

2017

J Emerg Infect Dis

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The impact of indoor residual spraying of deltamethrin on dengue vector populations in the Peruvian Amazon

Cited by 44 publications

References 19 publications

Deltamethrin resistance in Aedes aegypti results in treatment failure in Merida, Mexico

Deltamethrin resistance in Aedes aegypti results in treatment failure in Merida, Mexico

MiR-932 Regulates Pyrethroid Resistance inCulex pipiens pallens(Diptera: Culicidae)

Vector Control Interventions to Prevent Dengue: Current Situation and Strategies for Future Improvements to Management of Aedes in India

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