The Impact of Increased Body Mass Index on Systemic Lupus Erythematosus

Chaiamnuay, Sumapa; Bertoli, Ana M.; Fernández, Mónica; Apte, Mandar; Vilá, Luis M.; Reveille, John D.; Alarcón, Graciela S.

doi:10.1097/rhu.0b013e3180645865

Cited by 62 publications

(41 citation statements)

References 39 publications

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“…This finding is also observed in the general population and in other studies that assessed obesity and variations in BMI in patients with SLE [2,3,22]. Hormonal factors and a reduction in daily energy expenditures are related to age and may contribute to weight gain in these individuals [22].…”

Section: Discussionsupporting

confidence: 73%

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Excess weight and associated risk factors in patients with systemic lupus erythematosus

et al. 2012

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The objective of this study is to determine the socio-demographic, clinical and laboratory characteristics of outpatients with SLE who present with excess weight as well as to assess the immunosuppressive therapy used. One hundred and seventy women with SLE were evaluated consecutively in a transversal study. The relationship between excess weight and the patients' characteristics was evaluated using univariate and multivariate Poisson regression analysis. Of the 170 patients evaluated, 109 presented with excess weight, two were malnourished and 59 were classified as eutrophic. Age and disease duration of those with excess weight were 42.4 ± 8.7 and 10.4 ± 6.2 years, respectively. Risk factors associated with excess weight were the following: age ≥40 years, <8 years of education, lack of occupation, damage index ≥1, systemic high blood pressure, diabetes mellitus and triglycerides ≥150 mg/dL levels. The use of antimalarial therapy and steroids was associated with a lower frequency of excess weight. Age ≥40 years and the non-usage of methotrexate were the variables independently associated with excess weight in the multivariate analysis. Patients with SLE who have excess weight present distinct clinical-laboratory findings, socio-demographic characteristics and treatment options when compared to normal weight patients. Prospective studies should assess whether these characteristics will interfere with the outcome or prognosis of lupus.

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Section: Discussionsupporting

confidence: 73%

“…The percentage of people with lupus who are overweight, in the majority of studies, varies from 56 to 67 % [2][3][4][5].…”

Section: Introductionmentioning

confidence: 98%

Excess weight and associated risk factors in patients with systemic lupus erythematosus

et al. 2012

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“…The increasing of body mass index correlate with age, low social support, and depression (OR 1.091, 95% confidence interval 1.026-1.159, p = 0.005), but not correlate to disease activity, and patient quality of life [24].…”

Section: Resultsmentioning

confidence: 99%

The Correlation between Serum Concentration of Vitamin D with Vitamin D Receptor Expression and Disease Activity in Indonesian Patients with Systemic Lupus Erythematosus: Preliminary Study

Handono¹,

Tanuwijaya²,

Fitri³

et al. 2014

JTLS

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The vitamin D role on the immune response of systemic lupus erythematosus (SLE) patient is mediated by vitamin D receptor (VDR). Low level of vitamin D correlated with disease activity in SLE patients, and circulating levels of activated vitamin D (1,25(OH)2D) contribute to VDR protein levels and its function. The objective of this study was to determine the correlation between vitamin D status with expression of VDR in peripheral blood mononuclear cell (PBMC) and the disease activity in SLE patients. The Research Subjects were 15 SLE patients (ACR 1997 criteria) fr om the RheumatoImmunology Division, dr. Saiful Anwar Hospital, Malang and 5 healthy controls. Serum vitamin D (25(OH)D3) level was assessed using ELISA method. VDR expression in PBMC was assessed using immunocytochemistry technique. The disease activity was measured by Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) score. This study showed no difference on VDR expression in PBMC between patient and healthy control group, but patient with vitamin D deficiency had lower VDR expression in PBMC than the other group. No difference on SLEDAI score between the group. Vitamin D status correlated positively with VDR expression in PBMC (p < 0,035, r = 0,473). However vitamin D status did not correlate with disease activity scores (p = 0,686).

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“…The side effects of steroids, such as a "moon face" and weight gain have an additional negative impact on self-esteem. (NavarreteNavarrete et al, 2010;Ng & Chan, 2007;Chaiamnuay et al, 2007) The persons with SLE often have worries about their illness, their treatment plans, the level of pain caused by the illness, and the occurrence of the next "flare-up". These people often have a sense of helplessness that the illness is not yet curable even after appropriate treatment is adopted.…”

Section: Etiopathogenesismentioning

confidence: 99%

Integral Treatment of Systemic Lupus Erythematosus

Parrondo¹

2011

Challenges in Rheumatology

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The Impact of Increased Body Mass Index on Systemic Lupus Erythematosus

Cited by 62 publications

References 39 publications

Excess weight and associated risk factors in patients with systemic lupus erythematosus

Excess weight and associated risk factors in patients with systemic lupus erythematosus

The Correlation between Serum Concentration of Vitamin D with Vitamin D Receptor Expression and Disease Activity in Indonesian Patients with Systemic Lupus Erythematosus: Preliminary Study

Integral Treatment of Systemic Lupus Erythematosus

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