The impact of IL18 gene polymorphisms on mRNA levels and interleukin-18 release by peripheral blood mononuclear cells

Dziedziejko, Violetta; Kurzawski, Mateusz; Paczkowska, Edyta; Machalinski, Bogdan; Pawlik, Andrzej

doi:10.5604/17322693.1000980

Cited by 21 publications

(19 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The association of two functional polymorphisms in the IL‐18 promoter, −607C/A (rs1946518) and −137G/C (rs187238), with the risk of BD was investigated previously in different populations. Our results showed similar association concerning the −607 (C/A) SNP in the Korean population where BD patients had a significantly higher frequency of the −607 C allele (60.7% vs. 48.1%, OR 1.668, 95% CI 1.129–2.464, P = 0.0101) . On contrary, opposite results were observed in the Turkish population, where a genetic association between allele ‘A’ in rs1946518 (−607 C/A) and BD (39% vs. 19%, OR = 1.48, 95% CI = 1.10–1.97, P = 0.0088) was detected .…”

Section: Discussionsupporting

confidence: 76%

“…IL-18 gene is located on chromosome 11q22. 2-22.3 (18), and several polymorphisms within IL-18 promoter gene have been associated with different inflammatory and autoimmune diseases (19)(20)(21)(22)(23). In addition, many investigators identified a significant higher frequency of À137 GG and the CC À607 genotypes in BD patients in comparison with controls (24,25).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

IL‐18 gene polymorphisms in aphthous stomatitis vs. Behçet's disease in a cohort of Egyptian patients

Hazzaa

Rashwan

Attia

2014

J Oral Pathology Medicine

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 76%

Section: Introductionmentioning

confidence: 99%

IL‐18 gene polymorphisms in aphthous stomatitis vs. Behçet's disease in a cohort of Egyptian patients

Hazzaa

Rashwan

Attia

2014

J Oral Pathology Medicine

View full text Add to dashboard Cite

show abstract

“…It has been shown that IL18 promoter gene polymorphisms rs187238 and rs1946518, may influence promoter activity and IL18 production [12,16,17]. Previous studies have indicated that IL16 and IL18 are pro-inflammatory cytokines involved in the pathogenesis of diabetes [13,[18][19][20].…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies www. journals.viamedica.pl/ginekologia_polska have revealed that cytokine production may be associated with polymorphisms in cytokine-encoding genes [12]. These polymorphisms may alter gene expression and cytokine synthesis, and have been investigated in patients with type 1 and type 2 diabetes [13].…”

Section: Introductionmentioning

confidence: 99%

IL16 and IL18 gene polymorphisms in women with gestational diabetes

Tarnowski

Wieczorek²,

Dziedziejko

et al. 2017

Ginekol Pol

Self Cite

View full text Add to dashboard Cite

Objectives: Gestational diabetes mellitus is a carbohydrate intolerance that occurs during pregnancy. Various inflammatory mediators are considered to be risk factors leading to GDM development. Among them are pro-inflammatory cytokines, such as IL16 and IL18. The aim of this study was to examine the association between IL16 and IL18 polymorphisms and GDM. Material and methods:This study included 204 pregnant women with GDM and 207 pregnant women with normal glucose tolerance (NGT). All samples were genotyped in duplicate using allelic discrimination assays with TaqMan® probes.Results: We observed that there was a decreased frequency of IL16 rs4778889 CC genotype carriers among women with GDM (CC vs. CT + TT: OR = 0.14; 95% CI = 0.02-1.15; p = 0.034). However, there was no significant difference in the distribution of alleles (C vs. T: OR = 0.81; 95% CI = 0.54-1.21; p = 0.30). There was a decreased frequency of the IL18 rs187238 G allele among GDM women (G vs. C: OR = 0.71; 95% CI = 0.53-0.96; p = 0.027). We also observed a decreased frequency of the IL18 rs1946518 T allele among women with GDM; however, this difference had only borderline statistical significance. We observed an association between IL18 rs187238, rs1946518 and BMI in pregnant women. Conclusions:The results of this study suggest that IL18 rs187238 and rs1946518 polymorphisms may be associated with an increased risk of GDM as well as with BMI in pregnant women.

show abstract

“…For position −137, a change from nucleotide G to nucleotide C affects the H4TF-1 nuclear factor binding site, which may confer a higher IL-18 protein expression [32]. Furthermore, a recent study reported by Dziedziejko et al [33] also found rs1946518 (−607A/C) AA homozygotes showed significantly lower IL-18 release and mRNA expression after stimulation(stimulants: PHA, LPS, and anti-CD3/CD28 antibodies),and as well as rs187238 (−137G/C) C allele after PHA treatment. These observations support our study, in which IL-18 rs1946518 C allele was associated with high IL-18 production, and high levels of IL-18 were associated with RA and SLE [8,9], so IL-18 rs1946518 A allele might have a protective effect on RA and SLE.…”

Section: Discussionmentioning

confidence: 99%

Association of IL-18 polymorphisms with rheumatoid arthritis and systemic lupus erythematosus in Asian populations: a meta-analysis

et al. 2012

View full text Add to dashboard Cite

BackgroundInterleukin (IL)-18, an important proinflammatory cytokine, plays a potential pathological role in rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Studies on the relationship of IL-18 gene promoter rs1946518 (−607A/C) polymorphism, rs187238 (−137G/C) polymorphism with RA and SLE are inconclusive. The aim of this study was to get a more precise estimation of the relationship in Asian populations.MethodsMeta-analysis was conducted on the associations between the IL-18 (−607A/C and -137G/C) polymorphisms and RA and SLE, using; (1) allele contrast, (2) dominant, and (3) recessive models. A total of 11 studies were included in this study.ResultsFor the relationship of IL-18 rs1946518 polymorphism with RA (additive model: OR=0.752, 95%CI=0.562-1.006; dominant model: OR=0.730, 95%CI =0.479-1.113; recessive model: OR=0.537, 95%CI=0.271-1.064) and SLE (additive model: OR=0.684, 95%CI=0.455-1.028; dominant model: OR=0.645, 95%CI=0.368-1.130; recessive model: OR=0.672, 95%CI =0.447-1.010), no significant association with RA and SLE risk can be found under all genetic models in Asian populations. However, significant associations were observed in Chinese population for both RA ((OR=0.688, 95%CI =0.532-0.889) and SLE (OR=0.606, 95%CI =0.396-0.930) under additive model. For the relationship between IL-18 rs187238 polymorphism and RA or SLE, there was no significant association detected in all genetic models, even in Chinese population.ConclusionsThis meta-analysis indicates that the IL-18-607A/C polymorphism may confer susceptibility to RA and SLE in Chinese population, but not all Asians.

show abstract

The impact of IL18 gene polymorphisms on mRNA levels and interleukin-18 release by peripheral blood mononuclear cells

Abstract: Our study supports the role of rs1946518 (-607A>C) and rs187238 (-137G>C) SNPs as genetic determinants of the observed variability in IL18 expression.

Cited by 21 publications

References 0 publications

IL‐18 gene polymorphisms in aphthous stomatitis vs. Behçet's disease in a cohort of Egyptian patients

IL‐18 gene polymorphisms in aphthous stomatitis vs. Behçet's disease in a cohort of Egyptian patients

IL16 and IL18 gene polymorphisms in women with gestational diabetes

Association of IL-18 polymorphisms with rheumatoid arthritis and systemic lupus erythematosus in Asian populations: a meta-analysis

Contact Info

Product

Resources

About