The impact of Cymbopogon martinii essential oil on Cutibacterium (formerly Propionibacterium) acnes strains and its interaction with keratinocytes

Abstract

Objectives The human skin microbiota is mainly composed of bacteria belonging to the genera Staphylococcus, Cutibacterium, Micrococcus and Corynebacterium, but on the skin of the face and back, ca. 50% of the total microbiota is represented by the bacterium Cutibacterium acnes. The aim of this research was to evaluate the impact of C. martini EO and its major compound, geraniol, on C. acnes. Methods The minimum inhibitory concentration against C. acnes strains, phenotypic changes and responses of the proteome was determined. In addition, was assessed the effect of compounds in RNA‐binding assay, on C. acnes‐exposed keratinocytes and on the C. acnes type distribution on shoulder skin. Key findings The range of the MIC was 0.7 to 1.6 mg/ml for the three main C. acnes types. There were no cytotoxic effects of compounds in the absence or presence of C. acnes; after 7 days of exposure to C. martini EO, we could not detect a major shift of the C. acnes types on shoulder skin that was found to be dominated by C. acnes strains of types II and IA2. Conclusions Our work gives novel insight into the skin microbiota‐interacting properties of C. martini EO.

Extraction of essential oil from Citrus reticulate Blanco peel and its antibacterial activity against Cutibacterium acnes (formerly Propionibacterium acnes)

“…Traditional medical plants and their extracts provide good choices for the treatment of C. acne and show excellent results in bacteriostasis research (Hamdy et al., 2017; Jeong and Kim, 2017; Poomanee et al., 2018). EOs from other plant extracts have good antimicrobial properties and they are valid against C. acne (Millerm A et al., 2015; Murbach Teles Andrade et al., 2018). Citrus EO contains a lot of bioactive substances (Dosoky and Setzer, 2018).…”

Anti-ultraviolet, antibacterial, and biofilm eradication activities against Cutibacterium acnes of melanins and melanin derivatives from Daedaleopsis tricolor and Fomes fomentarius

“…Thus, searching for alternative antimicrobial compounds from natural materials is crucial. Previous studies found that essential oils from some plants, e.g., cloves, cacti, and tea trees, significantly inhibited the growth of C. acnes (Murbach Teles Andrade et al, 2018;Ossa-Tabares et al, 2020). There has not been any research attempting to investigate the antibacterial and antibiofilm activities of melanins against C. acnes.…”

Antibacterial Activity of the Essential Oil From Litsea cubeba Against Cutibacterium acnes and the Investigations of Its Potential Mechanism by Gas Chromatography-Mass Spectrometry Metabolomics

“…In recent years, more and more attention has been paid to natural products derived from plants due to their higher efficacy and lower toxicity, which can replace or assist antimicrobial agents in inhibiting the proliferation of C. acnes ( De Canha et al, 2019 ; Di Lodovico et al, 2020 ; Wei et al, 2021 ). Accumulating evidence showed that many essential oils from plants such as cloves, cactus, tea tree, and so on possessed an inhibitory effect on C. acnes ( Fu et al, 2009 ; Murbach Teles Andrade et al, 2018 ; Ossa-Tabares et al, 2020 ). However, there is a lack of research on the mechanism underlying the antibacterial activity.…”