The impact of <i>Chlamydia trachomatis</i> infection on sperm parameters and male fertility: A comprehensive study

Moazenchi, Maedeh; Totonchi, Mehdi; Yazdi, Reza Salman; Hratian, K; Meybodi, Mohammad Ali Mohseni; Panah, M Ahmadi; Chehrazi, Mohammad; Meybodi, Anahita Mohseni

doi:10.1177/0956462417735245

Cited by 41 publications

(29 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to the literature, results about the effects of Chlamydia infection on semen parameters are controversial. Moazenchi and colleagues showed that 11% of those infected with C. trachomatis had sperm abnormali- ties (32). In the current study, only azoospermic specimens infected with C. trachomatis had a significant association with sperm abnormalities (P < 0.05), and no significant association with nonazoospermic samples was found (P > 0.05).…”

Section: Discussioncontrasting

confidence: 54%

Prevalence of Chlamydia trachomatis and Listeria monocytogenes in Infertile Men and the Effect on Semen Parameters

Tohidpour

Shahhosseiny

Mehrabian

et al. 2020

Jundishapur J Microbiol

View full text Add to dashboard Cite

Background: Infertility is one of the serious problems in gynecology and one of the most important issues of concern in couples. Meanwhile, a significant rise in infertility is recently reported in Iran due to the infections and harsh environmental conditions. Objectives: The current study aimed to detect Chlamydia trachomatis and Listeria monocytogenes in males with infertility using PCR, and to evaluate bacteriospermia effects of the studied bacteria on semen parameters. Methods: Semen specimens of 100 infertile men were collected. Then, each specimen was divided into two parts: the first part was tested by semen analysis according to the WHO guidelines and the second was tested using the PCR method. The PCR intended to identify C. trachomatis and L. monocytogenes. Results: Out of 100 semen samples, 20% were positive for C. trachomatis, 3% were positive for L. monocytogenes, and 3% were positive for both bacteria (coinfection). The leukocyte count was higher than the normal range (0 - 1 Mil/mL) in all semen specimens. The prevalence of C. trachomatis in azoospermic patients was significantly higher than that of nonazoospermic (P < 0.05). However, there was no significant difference between the two groups in terms of the detection of L. monocytogenes (P > 0.05). Detection of C. trachomatis and L. monocytogenes had no significant association with abnormal semen parameters in asymptomatic patients (P > 0.05). Conclusions: The results indicated that precise analysis of semen parameters and diagnosis of leukocytospermia in patients using the PCR can be considered as a rapid and accurate technique to detect bacteria such as C. trachomatis and L. monocytogenes in semen specimens. Therefore, the utilization of this technique in the screening programs for asymptomatic infertile couples can be helpful for early treatment.

show abstract

Section: Discussioncontrasting

confidence: 54%

Prevalence of Chlamydia trachomatis and Listeria monocytogenes in Infertile Men and the Effect on Semen Parameters

Tohidpour

Shahhosseiny

Mehrabian

et al. 2020

Jundishapur J Microbiol

View full text Add to dashboard Cite

show abstract

“…Notably, although it is not clear whether ICI‐induced epididymo‐orchitis affects future fertility, other causes of this condition may reduce sperm count and impair fertility. Thus, a fertility evaluation following symptom resolution may be indicated in patients desirous of maintaining fertility .…”

Section: Discussionmentioning

confidence: 99%

Severe Epididymo-Orchitis and Encephalitis Complicating Anti-PD-1 Therapy

et al. 2019

View full text Add to dashboard Cite

Background Immune checkpoint inhibitors such as pembrolizumab and nivolumab have emerged as active treatment options for patients with many cancers, including metastatic melanoma, but can also cause symptomatic or life‐threatening immune‐related adverse events, including encephalitis. Epididymitis and orchitis are rare complications of these therapies. Case Presentation We describe herein a patient with metastatic melanoma who developed epididymo‐orchitis followed by encephalitis while receiving pembrolizumab. The patient developed testicular pain and fever after his third dose of pembrolizumab; ultrasound evaluation demonstrated bilateral epididymo‐orchitis. He then developed headaches, fever, and altered mental status over the next week and was admitted to the hospital. Lumbar puncture revealed inflammatory changes consistent with meningoencephalitis; he did not improve with broad‐spectrum antibiotics, and an extensive workup for infectious etiologies, including cerebrospinal fluid testing using a clinical metagenomic next‐generation sequencing assay, was negative. He received high‐dose steroids for suspected autoimmune encephalitis, and both his orchitis and meningoencephalitis improved rapidly after one dose. He fully recovered after a 5‐week taper of oral steroids. Discussion Here, we report a case of epididymo‐orchitis complicating immune checkpoint inhibitor therapy. This patient subsequently developed severe encephalitis but rapidly improved with steroids. Clinicians should be aware of rare complications of these agents. Key Points Epididymo‐orchitis is a rare and potentially life‐threatening complication of anti‐programmed death protein 1 (anti‐PD‐1) therapy. For patients on anti‐PD‐1 therapy who develop either epididymo‐orchitis or epididymitis without clear infectious cause, immune‐related adverse events should be considered in the differential diagnosis. If severe, epididymo‐orchitis related to anti‐PD‐1 therapy may be treated with high‐dose corticosteroids.

show abstract

“…Approximately 50% of CT infections in men are asymptomatic (106,107). The most important profile of a CT infection is a local immune response.…”

Section: Immune Response Induced By Chlamydia Trachomatismentioning

confidence: 99%

The Immune Characteristics of the Epididymis and the Immune Pathway of the Epididymitis Caused by Different Pathogens

Zhao

et al. 2020

Front. Immunol.

View full text Add to dashboard Cite

The epididymis is an important male accessory sex organ where sperm motility and fertilization ability develop. When spermatozoa carrying foreign antigens enter the epididymis, the epididymis shows "immune privilege" to tolerate them. It is well-known that a tolerogenic environment exists in the caput epididymis, while pro-inflammatory circumstances prefer the cauda epididymis. This meticulously regulated immune environment not only protects spermatozoa from autoimmunity but also defends spermatozoa against pathogenic damage. Epididymitis is one of the common causes of male infertility. Up to 40% of patients suffer from permanent oligospermia or azoospermia. This is related to the immune characteristics of the epididymis itself. Moreover, epididymitis induced by different pathogenic microbial infections has different characteristics. This article elaborates on the distribution and immune response characteristics of epididymis immune cells, the role of epididymis epithelial cells (EECs), and the epididymis defense against different pathogenic infections (such as uropathogenic Escherichia coli, Chlamydia trachomatis, and viruses to provide therapeutic approaches for epididymitis and its subsequent fertility problems.

show abstract

The impact of Chlamydia trachomatis infection on sperm parameters and male fertility: A comprehensive study

Cited by 41 publications

References 39 publications

Prevalence of Chlamydia trachomatis and Listeria monocytogenes in Infertile Men and the Effect on Semen Parameters

Prevalence of Chlamydia trachomatis and Listeria monocytogenes in Infertile Men and the Effect on Semen Parameters

Severe Epididymo-Orchitis and Encephalitis Complicating Anti-PD-1 Therapy

The Immune Characteristics of the Epididymis and the Immune Pathway of the Epididymitis Caused by Different Pathogens

Contact Info

Product

Resources

About