The Impact of Hypoxic Exposures in Different Periods of Prenatal Development on Electrical Activity of the Rabbit Auditory Cortex in the First Month of Postnatal Life

Guseynov, A. G.

doi:10.1134/s0022093021060089

Cited by 1 publication

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References 55 publications

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“…The study of how various stressors during the intrauterine period affect further brain development during postnatal ontogenesis is of considerable interest to neurobiologists. The effects of prenatal hypoxia can appear in adult animals in the form of short-and long-term impairments of cognitive function and delayed reflex development [3,4,5]. The disturbances in learning, memory, and behavior observed in animals are associated with the processes occurring in the maturing brain during the period of exposure to an adverse factor.…”

Section: Introductionmentioning

confidence: 99%

Impact of hypoxic preconditioning on the alterations in phosphate-activated glutaminase activity in the brains of offspring

Gadirova

2023

Azerbaijan Journal of Physiology

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The hypoxic preconditioning model is widely used in experimental studies to identify mechanisms for increasing the tolerance of organisms to subsequent hypoxic exposure. Glutaminase is the main enzyme that synthesizes glutamate, which has two important physiological roles: in the postnatal period, it acts as an excitatory neurotransmitter, and during the prenatal period, it regulates neurogenesis, synaptogenesis, and the survival of nerve cells. In our work, in 4 experimental groups, we investigated the effect of hypoxic preconditioning performed during days 16–21 of pregnancy on glutamate synthesis in the brains of 17-day-old and 6-month-old offspring. It was found that prenatal hypoxia led to a pronounced increase in the enzyme activity in various brain structures in early postnatal ontogenesis, while a decrease was observed in adult animals. In contrast, exposure to acute hypoxia resulted in a more significant increase in glutaminase activity in the brains of adult animals. Prenatal fetal hypoxic preconditioning caused a weakening effect on the increase in enzyme activity in 17-day-old rat offspring and a down-regulation in 6-month-olds, compared to the group that suffered acute hypoxia in the postnatal period. Thus, a neuroprotective adaptive-compensatory effect of prenatal preconditioning has been demonstrated, which can be associated with both the physiological and excitotoxic effects of glutamate.

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Section: Introductionmentioning

confidence: 99%

Impact of hypoxic preconditioning on the alterations in phosphate-activated glutaminase activity in the brains of offspring

Gadirova

2023

Azerbaijan Journal of Physiology

View full text Add to dashboard Cite

show abstract

The Impact of Hypoxic Exposures in Different Periods of Prenatal Development on Electrical Activity of the Rabbit Auditory Cortex in the First Month of Postnatal Life

Cited by 1 publication

References 55 publications

Impact of hypoxic preconditioning on the alterations in phosphate-activated glutaminase activity in the brains of offspring

Impact of hypoxic preconditioning on the alterations in phosphate-activated glutaminase activity in the brains of offspring

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