The impact of hyperlipidemia and carotid atherosclerosis

Yang, Szu‐Ting; Liu, Chia-Hao; Wang, Peng-Hui

doi:10.1097/jcma.0000000000000909

Cited by 3 publications

(4 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We would like to thank Yang et al for their interest in our work. 1 In their Letter to the Editor, they summarized our most important findings and also raised several concerns about our work. 2 Listed below are our responses for their concerns.…”

Section: Dear Editormentioning

confidence: 99%

“…For the third concern, Yang et al pointed out that the uses of antihypertensive, antidiabetic, and antihyperlipidemic medications are critical confounding factors. 1 Indeed, in the study, the definitions of hypertension, diabetes mellitus (DM), and hyperlipidemia included subjects who currently use antihypertensive, antidiabetic, and antihyperlipidemic medications, respectively. However, the uses of these medications are not qualified as confounders.…”

Section: Dear Editormentioning

confidence: 99%

See 1 more Smart Citation

Reply to “The impact of hyperlipidemia and carotid atherosclerosis”

Wang

Chou

et al. 2023

Journal of the Chinese Medical Association

View full text Add to dashboard Cite

Section: Dear Editormentioning

confidence: 99%

Section: Dear Editormentioning

confidence: 99%

Reply to “The impact of hyperlipidemia and carotid atherosclerosis”

Wang

Chou

et al. 2023

Journal of the Chinese Medical Association

View full text Add to dashboard Cite

“…It has been shown that the in ammatory response plays an important role in the development and progression of AS 2 . During the activation of the in ammatory response, the release of multiple pro-in ammatory cytokines can promote the formation of atheromatous plaques after the in ltration and phagocytosis of lipids by in ammatory cells in the intima of arteries, thus promoting the development of AS 3,4 .…”

Section: Introductionmentioning

confidence: 99%

Carvedilol ameliorates experimental atherosclerosis by inhibiting the NLRP3 inflammasome

Xu,

Yan,

et al. 2024

Preprint

View full text Add to dashboard Cite

Objective: To investigate the protective effect of carvedilol against atherosclerosis by inhibiting the NLRP3 inflammasome. Methods：In vitro experiments, human umbilical vein endothelial cells(HUVEC) were divided into the control group, ox-LDL group, carvedilol 5μM group, carvedilol 10μM group, and carvedilol 20μM group. The optimal concentration of carvedilol was determined using the CCK-8 method to assess cell proliferation levels and oil red O staining to observe intracellular lipid droplet formation. Subsequently, the cells were further divided into the control group, ox-LDL group, carvedilol 5μM (optimal concentration) group, and MCC950 (inhibitor of NLRP3 Inflammasome) group. The expression levels of intracellular proteins NLRP3, pro-Caspase-1, Caspase1, pro-IL-1β, IL-1β, p65, GSDMD, and N-GSDMD were detected by ELISA, or Western Blotting. Results: Compared to the control group, the ox-LDL group exhibited a significant reduction in cell proliferation level (P<0.05), accompanied by an increase in lipid droplet formation upon induction. In contrast, pretreatment with carvedilol at concentrations of 5μM, 10μM, and 20μM effectively promoted cell proliferation (P<0.05) and inhibited intracellular lipid droplet formation. Notably, the most pronounced effect was observed with carvedilol pretreatment at a concentration of 5μM. Furthermore, compared to the control group, HUVEC cells in the ox-LDL group demonstrated substantial upregulation of NLRP3, pro-Caspase-1, Caspase1, pro-IL-1β, IL-1β, p65 GSDMD and N-GSDMD; however, these markers were downregulated following treatment with carvedilol and MCC950 administration-particularly evident in the carvedilol group. Conclusion: Carvedilol effectively inhibits the progression of atherosclerosisby targeting the NLRP3 inflammasome, thereby providing valuable mechanistic insights into its beneficial effects on atherosclerotic cardiovascular disease.

show abstract

“…We totally agree the audience' comments that there are many confounding factors contributing to Dr. Lu's finding and subsequent conclusion. 16 At the end, just like our concerns about the statistical significance in the research works, any conclusion and/or recommendation made should be based on the clinical relevance and not just relegate the patients with statistical significance to decision-making only involving the experts' interest. 17,18…”

mentioning

confidence: 99%

Is weight of hypertension heavier than dyslipidemia and diabetes mellitus on carotid atherosclerosis?

Lee

Wang

2023

Journal of the Chinese Medical Association

Self Cite

View full text Add to dashboard Cite

Cardiovascular disease (CVD) remains one of the most common causes of impairment of human well-being and is also the main cause of death in the world. 1 CVD is apparently the biggest health problem in Taiwan since it is secondary to malignant diseases and ranks as the second leading cause of mortality in Taiwan. 2 Any strategy to screen and/or identify the risk factors and/or precursors of CVD providing a better chance to prevent or delay adverse health outcomes by early detection and prompt intervention and subsequently to improve global health is always encouraged. 1,3,4 CVD is a noncommunicable disease, partly because of the presence of high debates about risk scoring system, part of the uncertainty of the value of using screening for asymptomatic CVD, particularly for asymptomatic carotid atherosclerosis, and partly because of the argument of appropriate time to intervention or management. [5][6][7][8][9] We are happy to introduce a manuscript entitled "Combined effects of hypertension, hyperlipidemia, and diabetes mellitus (DM) on the presence and severity of carotid atherosclerosis in community-dwelling elders: A community-based study" published in the February issue of the Journal of the Chinese Medical Association to focus on the topic. 10 Lu et al investigate the effect of comorbidities, such as hypertension, DM, and hyperlipidemia on carotid atherosclerosis in community-dwelling elders and found that many well-known risk factors, such as age at enrollment (per 1 year), male gender, cigarette smoking, and number of common CVD comorbidities are associated with carotid atherosclerosis, and also involved in the severity of carotid atherosclerosis. 10 Additionally, the authors attempted to investigate the effects of each comorbidity item or combined comorbidity items of hypertension, DM, and hyperlipidemia on carotid atherosclerosis and found that hypertension was the most critical factor .

show abstract

The impact of hyperlipidemia and carotid atherosclerosis

Cited by 3 publications

References 9 publications

Reply to “The impact of hyperlipidemia and carotid atherosclerosis”

Reply to “The impact of hyperlipidemia and carotid atherosclerosis”

Carvedilol ameliorates experimental atherosclerosis by inhibiting the NLRP3 inflammasome

Is weight of hypertension heavier than dyslipidemia and diabetes mellitus on carotid atherosclerosis?

Contact Info

Product

Resources

About