The impact of humic acid additives on mineral metabolism of rabbits in the postnatal period of ontogenesis

Hunchak, V.; Martynyshyn, V. P.; Gutyj, B. V.; Hunchak, A. V.; Stefanyshyn, O. M.; Парченко, В. В.

doi:10.15421/022044

Cited by 8 publications

(5 citation statements)

References 21 publications

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“…The next step was to obtain a number of alkyl derivatives [3][4][5][6][7][8][9]. The reaction was carried out in an alcoholic medium by adding an equivalent amount of alkali to the initial thiols and corresponding haloalkanes (Fig.…”

Section: Materials and Methods Of Researchmentioning

confidence: 99%

“…Such studies are undoubtedly promising and original. The new molecules obtained in this way exhibit a wide range of biological activity, and most of them are low-toxic, which is undoubted of great importance [7,8]. It is also interesting that the introduction of various pharmacophores into the molecule leads to the formation of new properties, which certainly opens opportunities for creating a new "ideal" compound.…”

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confidence: 99%

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Investigation of physical and chemical properties of new derivatives of 5-(thiophene-3-ylmethyl)-4R-1,2,4-triazole-3-thiols

Khilkovets

2021

АПФМНП

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Heterocyclic compounds are one of the most important branches of modern organic chemistry and are widely used in medicine, pharmacy, agriculture, and in the production of new materials. One of these compounds is 1,2,4-triazole, which has attracted the attention of scientists around the world for many years. The aim of the work is to synthesize new derivatives of 5-(thiophene-3-ylmethyl)-4R-1,2,4-triazole-3-thiols and study their physical-chemical properties, conducting primary pharmacological screening. Materials and methods. Organic synthesis classical methods were used in the study, as well as a complex of physical-chemical analysis methods (1H NMR spectroscopy, elemental analysis, Elisa and chromato-mass spectral studies) were done. Prediction of pharmacological activity was carried out by using the PASS online computer program. Results. Two initial compounds were obtained: 5-(thiophene-3-ylmethyl)-4phenyl-1,2,4-triazole-3-thiol and 5-(thiophene-3-ylmethyl)-4H-1,2,4-triazole-3-thiol. During their further chemical transformation, a number of new corresponding alkyl derivatives were obtained. The structure of the synthesized compounds was confirmed using modern physical-chemical methods of analysis. Based on the results of pharmacological screening, the high activity of the obtained compounds can be predicted. Conclusions. 5-(thiophene-3-ylmethyl)-4H-1,2,4-triazole-3-thiol, 5-(thiophene-3-ylmethyl)-4-phenyl-1,2,4-triazole-3-thiol and a number of their alkyl derivatives were synthesized. The structure and individuality were proved thanks to modern physical and chemical methods of analysis. Having analyzed the results of primary pharmacological screening of a number of obtained compounds, some of them were selected for further study.

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Section: Materials and Methods Of Researchmentioning

confidence: 99%

mentioning

confidence: 99%

Investigation of physical and chemical properties of new derivatives of 5-(thiophene-3-ylmethyl)-4R-1,2,4-triazole-3-thiols

Khilkovets

2021

АПФМНП

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“…The analysis of this indicator in toxicological studies makes it possible to identify the target organ of the toxicant, to identify signs of endocrine-related effects. The unique properties of 1,2,4-triazole make this heterocycle very attractive for research (Bihdan et al, 2019;Hunchak et al, 2020). Studies have shown the high reactivity and low toxicity of 1,2,4-triazole derivatives and the prospect of their use as potential biologically active compounds.…”

Section: Features Of Experimental Modeling Of Tuberculosismentioning

confidence: 99%

Features of experimental modeling of tuberculosis in guinea pig with the participation of N'-(2-(5-((thephylline-7' yl)methyl)-4-R-1,2,4-triazole- ylthio)acethyl)isonicotinohydrazide

Gotsulya¹,

Zazhzharskiy²,

Давиденко³

2020

Ukr J Ecol

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In this study, no toxic effects were detected after single subcutaneous injection of 40 mg/kg tadpoles. The results of macro- and microscopic examination of the internal organs 14 days after single subcutaneous administration of N'-(2-(5-((thephylline-7'-yl)methyl)-4-ethyl-1,2,4-triazole-3-ylthio)acethyl)isonicotino-hydrazide (GKP-305) at a dose of 20, 40 mg/kg showed the absence of any anatomical and morphological abnormalities in the tissue structures of the tentacles. The calculated value of the drug indicates a high degree of safety GKP-305 and its prospects for veterinary practice as an effective and safe tuberculocidal drug.

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“…Ензими каталізують процеси метаболізму білків, жирів і вуглеводів (Martyshchuk & Gutyi, 2019;Martyshuk et al, 2019;Khalak et al, 2019;Hunchak et al, 2020). При різних паразитологічних захворюваннях у крові тварин змінюється якісний та кількісний склад ензимів, що відображає інтенсивність і спрямованість розвитку патологічного процесу.…”

Section: таблицяunclassified

Protein-synthesizing function and functional state of the liver of dogs at experimental toxocariasis

et al. 2020

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The aim of the study was to investigate the effect of toxocariasis invasion on protein-synthesizing function and functional state of the liver of dogs. For experimental studies, 12 dogs aged from two to four months were used and two groups of six animals were formed in each: control and experimental. Puppies of the experimental group were experimentally infected with the pathogen toxocariasis at a dose of 5,000 invasive eggs of T. canis per kg of body weight. The control puppies were clinically healthy. Protein-synthesizing function of the liver of dogs in experimental toxocariasis was studied by the level of total protein and its fractions. It was found that on the 25th day of the experiment the level of total protein in the blood of the experimental group of dogs was 56.9 ± 1.47 g/l, while in the control group – 63.8 ± 2.92 g/l. The lowest level of the studied indicator was on the 30th day of the experiment in the blood of the experimental group of dogs, where it decreased by 9.6 %. The results of a study of protein fractions in the blood of dogs infested with toxocara showed that the percentage of albumin is likely to decrease. However, in the blood of infected dogs in this period of research there was a probable increase in globulin levels. The study of the effect of toxocariasis invasion on the activity of enzymes in blood serum is a test for the morphological and functional state of tissues and organs. Based on the studies, it was found that with the development of toxocariasis invasion in dogs there is an increase in alanine aminotransferase in their serum. On the 25th and 30th day of the experiment, the activity of the enzyme in the serum of infected dogs was the highest, where compared with the control group of dogs, the activity of ALT increased by 51.2 and 59.1 %, respectively. Similar changes in activity were observed in the determination of aspartate aminotransferase, where, respectively, on the 15th, 20th and 25th day of the experiment, the activity of AST in the serum of infected dogs increased by 19.3, 27.5 and 39.1 %.

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The impact of humic acid additives on mineral metabolism of rabbits in the postnatal period of ontogenesis

Cited by 8 publications

References 21 publications

Investigation of physical and chemical properties of new derivatives of 5-(thiophene-3-ylmethyl)-4R-1,2,4-triazole-3-thiols

Investigation of physical and chemical properties of new derivatives of 5-(thiophene-3-ylmethyl)-4R-1,2,4-triazole-3-thiols

Features of experimental modeling of tuberculosis in guinea pig with the participation of N'-(2-(5-((thephylline-7' yl)methyl)-4-R-1,2,4-triazole- ylthio)acethyl)isonicotinohydrazide

Protein-synthesizing function and functional state of the liver of dogs at experimental toxocariasis

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