The impact of housing conditions on mortality in Belgium (1991–2016)

Joan, Damiens

doi:10.1007/s12546-020-09252-y

Cited by 7 publications

(11 citation statements)

References 25 publications

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“…(2018) showed an increase in social and spatial inequalities in Belgium between 1991 and 2016, pointing out that inequalities are greatest among individuals aged 25 to 50 [20], in line with our results depicting that mortality attributable to housing inequality peaks between the ages 40-49. The study by Damiens (2020) on the impact of housing conditions on mortality in Belgium concluded that low-quality housing may result in an increase in mortality rates by 25% after controlling for education, professional status and income, whereas in our study, the difference between the most and least deprived groups ranged between 28-40% for men and 18-25% for women [14].…”

Section: Discussioncontrasting

confidence: 84%

“…Findings from existing studies on the association between poor housing conditions in Belgium and adverse health outcomes are concurrent with ndings reported worldwide [14,20,22]. In contrast with these individual-level studies, we aim to investigate the association between inequality in mortality and housing conditions on the aggregated level.…”

Section: Introductionmentioning

confidence: 88%

“…In Belgium, a recent study showed that mortality among tenants was about 25% higher than among home owners, and a similar excess mortality was observed among those living in low quality housing, even after controlling for education, professional status and income [14]. An increase in the number of inadequately housed people has also been observed in certain parts of Belgium.…”

Section: Introductionmentioning

confidence: 91%

“…The differences in housing quality among the three regions are large -with housing inequality being lowest in the Flemish region, and greatest in the Brussels-Capital Region [14,[19][20][21].…”

Section: Introductionmentioning

confidence: 99%

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Inequalities in mortality associated with housing conditions in Belgium between 1991 and 2020

Otavova

Faes

Bouland

et al. 2022

Preprint

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BackgroundPoor housing conditions have been associated with increased mortality. Our main objective is to investigate association between housing inequality and increased mortality and to estimate the number of deaths that could be prevented if the population of Belgium faced the mortality rates of the least deprived housing deprivation decile.MethodsWe utilized individual-level mortality data extracted from the National Register in Belgium and relative to deaths that occurred between Jan 1, 1991 and Dec 31, 2020. Spatial and time-specific housing deprivation indices (1991, 2001, and 2011) were created at the level of the smallest geographical unit in Belgium, assigning these units into deciles from the most to least deprived. We calculated mortality attributable to housing inequality as the difference between the observed and expected deaths by applying mortality of the least deprived decile to other deciles. We also used standard life table calculations to estimate the potential years of life lost due housing inequality. Results18.5% (95% CI 17.7-19.3) of all deaths between 1991 and 2020 were attributable to housing inequality, corresponding to 584,875 deaths. Over time, life expectancy at birth increased for the most and least deprived deciles by about 3.5 years. The gap in life expectancy between the two deciles remained high, on average 4.6 years. Life expectancy in Belgium is reduced by approximately 3 years lost due to housing inequality. Conclusions Thousands of deaths in Belgium could be avoided if housing inequality was reduced. Hotspots of housing inequalities need to be localized and targeted with tailored public actions.

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Section: Discussioncontrasting

confidence: 84%

Section: Introductionmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

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Inequalities in mortality associated with housing conditions in Belgium between 1991 and 2020

Otavova

Faes

Bouland

et al. 2022

Preprint

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“…The CRISPR system is a bacterial adaptive immune system that requires the endonuclease Cas9 from Streptococcus pyogenes (or analogous proteins from other species) and a single guide of RNA (sgRNA). That guide leads the nuclease activity to complementary sequences in the substrate DNA, usually on the coding region (14). CRISPR/Cas9 is used for genome editing by introducing deletions on the protein coding ORF (open reading frame) using homology repair (HR) or nonhomologous end joining (NHEJ) repair.…”

Section: Introductionmentioning

confidence: 99%

A CRISPR interference strategy for gene expression silencing in multiple myeloma cell lines

Poch

Escrivá-Fernández

Cueto-Ureña

et al. 2022

Preprint

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Background: Multiple myeloma is the second most common hematologic neoplasm which is characterized by proliferation and infiltration of plasmatic cells in the bone marrow. Currently, MM is considered incurable due to treatment resistance. The CRISPR/Cas9 gene editing system has been recently used in several cell lines and mouse models to understand the role of various genetic alterations in pathogenesis of hematologic malignancies. Despite the recent advances of gene edition tools, the use of CRISPR/Cas9 technology for gene editing of MM have not so far been extended. In this work, we want to repress Rnd3 expression, an atypical Rho GTPase involved in several cellular processes, in MM cell lines using a CRISPR interference strategy. Results: We have designed different guide RNAs and cloning them into a lentiviral plasmid, which contain all the machinery necessary for develop the CRISPR interference strategy. We co-transfected the HEK 293T cells with this lentiviral plasmid and 3rd generation lentiviral envelope and packaging plasmids for the production of lentiviral particles. The lentiviral particles were used to transduce two different multiple myeloma cell lines, RPMI 8226 and JJN3, and downregulate Rnd3 expression.Conclusions: We have developed a CRISPR interference strategy to generate stable Rnd3 knockdown MM cell lines by lentiviral transduction. We have evaluated this strategy in two MM cell lines and we have demonstrated that Rnd3 silencing works both at transcriptional and protein level. Therefore, we propose CRISPR interference strategy as an alternative tool to silence gene expression in MM cell lines.

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The Relationship Between Physical Housing Characteristics, Housing Accessibility and Different Aspects of Health Among Community-Dwelling Older People: A Systematic Review

et al. 2023

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Objectives To synthesize the evidence on the relationships between physical housing characteristics or housing accessibility and different aspects of health among community-dwelling people 60 years and older. Methods A systematic review of recent evidence with a narrative synthesis was conducted. Results We included 15 studies and found three themes covering physical housing characteristics or housing accessibility that are associated with aspects of health among community-dwelling older adults: (1) interventions by home modifications targeting housing features both at entrances and indoors; (2) non-interventions targeting indoor features; (3) non-interventions targeting entrance features, that is, the presence of an elevator or stairs at the entrance. The overall quality of evidence across studies was assessed as very low. Discussion The findings highlight the need for studies with a stronger research design and higher methodological quality that address the physical housing environment in relation to health among older adults to strengthen the body of evidence.

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The impact of housing conditions on mortality in Belgium (1991–2016)

Cited by 7 publications

References 25 publications

Inequalities in mortality associated with housing conditions in Belgium between 1991 and 2020

Inequalities in mortality associated with housing conditions in Belgium between 1991 and 2020

A CRISPR interference strategy for gene expression silencing in multiple myeloma cell lines

The Relationship Between Physical Housing Characteristics, Housing Accessibility and Different Aspects of Health Among Community-Dwelling Older People: A Systematic Review

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