The Impact of Hormesis, Neuronal Stress Response, and Reproduction, upon Clinical Aging: A Narrative Review

Kyriazis, Marios; Swas, Lama; Orlova, Tetiana

doi:10.3390/jcm12165433

Cited by 4 publications

(1 citation statement)

References 151 publications

(217 reference statements)

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“…In the following sections of this review, the different explanations that can help us understand this type of dose-response curve will be discussed in more detail. Among the biphasic responses produced by different drugs, with increasing interest, there is one known as the hormetic response [39,[64][65][66][67][68][69][70][71][72][73]. If we focus on antioxidant activity, hormesis is characterized by a protective and beneficial effect at very low doses, while increasing the concentration of the antioxidant causes damage (Figure 4).…”

Section: Dose-response Curves Hormesis and The Law Of Mass Actionmentioning

confidence: 99%

Enemies or Allies? Hormetic and Apparent Non-Dose-Dependent Effects of Natural Bioactive Antioxidants in the Treatment of Inflammation

Barreiro-Sisto,

Fernández-Fariña,

González-Noya

et al. 2024

IJMS

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This review aims to analyze the emerging number of studies on biological media that describe the unexpected effects of different natural bioactive antioxidants. Hormetic effects, with a biphasic response depending on the dose, or activities that are apparently non-dose-dependent, have been described for compounds such as resveratrol, curcumin, ferulic acid or linoleic acid, among others. The analysis of the reported studies confirms the incidence of these types of effects, which should be taken into account by researchers, discarding initial interpretations of imprecise methodologies or measurements. The incidence of these types of effects should enhance research into the different mechanisms of action, particularly those studied in the field of basic research, that will help us understand the causes of these unusual behaviors, depending on the dose, such as the inactivation of the signaling pathways of the immune defense system. Antioxidative and anti-inflammatory activities in biological media should be addressed in ways that go beyond a mere statistical approach. In this work, some of the research pathways that may explain the understanding of these activities are revised, paying special attention to the ability of the selected bioactive compounds (curcumin, resveratrol, ferulic acid and linoleic acid) to form metal complexes and the activity of these complexes in biological media.

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