The Impact of HMGB1 Polymorphisms on Prostate Cancer Progression and Clinicopathological Characteristics

Chou, Ying‐Erh; Yang, Po-Jen; Lin, Chia-Yen; Chen, Yen‐Yu; Chiang, Whei-Ling; Lin, Pei-Xuan; Huang, Zih-Yun; Huang, Matthew; Ho, Yung‐Chuan; Yang, Shun‐Fa

doi:10.3390/ijerph17197247

Cited by 8 publications

(5 citation statements)

References 53 publications

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“…In addition, HMGB1 directly interacts with TNFR1 and promotes the overexpression of MMP‐1, MMP‐3, and MMP‐10 by activating the NF‐κB signaling pathway 55,56 . It is confirmed that gastric carcinoma cell‐derived exosomes (GC‐Ex) induce increased autophagy response of neutrophils by transporting HMGB1 and interacting with TLR4 to activate the NF‐κB pathway and promote tumor activation 57 …”

Section: Pathways Related To Hmgb1mentioning

confidence: 85%

“…55,56 It is confirmed that gastric carcinoma cell-derived exosomes (GC-Ex) induce increased autophagy response of neutrophils by transporting HMGB1 and interacting with TLR4 to activate the NF-κB pathway and promote tumor activation. 57 Related inflammatory responses induced by this pathway, such as ω−3 polyunsaturated fatty acids (omega-3 PUFA) regulate microglia cell polarization through SIRT1-mediated HMGB1/NF-κB pathway deacetylation, thereby reducing inflammatory responses after brain injury to play a neuroprotective role. 58 In addition, during the development of acute glaucoma, HMGB1 activates the production of typical NLRP3, atypical caspase-8 inflammatory bodies, and IL-1β through the NF-κB pathway in response to acute ocular pressure increase, which can be regarded as a congenital response in the pathogenesis of glaucoma 59 (Figure 2).…”

Section: Nf-κb Pathwaymentioning

confidence: 99%

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High‐mobility group box 1 emerges as a therapeutic target for asthma

Yang,

Li,

Hou

et al. 2023

Immunity Inflam & Disease

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High‐mobility group box 1 (HMGB1) is a highly conserved nonhistone nuclear protein found in the calf thymus and participates in a variety of intracellular processes such as DNA transcription, replication and repair. In the cytoplasm, HMGB1 promotes mitochondrial autophagy and is involved in in cellular stress response. Once released into the extracellular, HMGB1 becomes an inflammatory factor that triggers inflammatory responses and a variety of immune responses. In addition, HMGB1 binding with the corresponding receptor can activate the downstream substrate to carry out several biological effects. Meanwhile, HMGB1 is involved in various signaling pathways, such as the HMGB1/RAGE pathway, HMGB1/NF‐κB pathway, and HMGB1/JAK/STAT pathway, which ultimately promote inflammation. Moreover, HMGB1 may be involved in the pathogenesis of asthma by regulating downstream signaling pathways through corresponding receptors and mediates a number of signaling pathways in asthma, such as HMGB1/TLR4/NF‐κB, HMGB1/RAGE, HMGB1/TGF‐β, and so forth. Accordingly, HMGB1 emerges as a therapeutic target for asthma.

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Section: Pathways Related To Hmgb1mentioning

confidence: 85%

Section: Nf-κb Pathwaymentioning

confidence: 99%

High‐mobility group box 1 emerges as a therapeutic target for asthma

Yang,

Li,

Hou

et al. 2023

Immunity Inflam & Disease

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“…The results indicated that the rs1360485 genotypes TC and CC were associated with better survival outcomes and could independently predict survival outcomes of patients with NEC. It has been found that the rs1360485 polymorphic variant of HMGB1 was associated with poor prognosis in patients with prostate cancer [ 26 ]. Therefore, we considered that the rs1360485 SNP of the HMGB1 gene was associated with susceptibility and survival prognosis in Chinese Han neonates with NEC.…”

Section: Discussionmentioning

confidence: 99%

Association of High-Mobility Group Box 1 (HMGB1) Gene Polymorphisms with Susceptibility and Better Survival Prognosis in Chinese Han Neonatal Necrotizing Enterocolitis

Cao

Guo

2021

Med Sci Monit

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Background High-mobility group box 1 (HMGB1) plays a crucial role in a variety of diseases, including neonatal necrotizing enterocolitis (NEC). The purpose of this study was to investigate the association of HMGB1 gene single-nucleotide polymorphisms (SNPs) with susceptibility and survival prognosis in Chinese Han neonates with NEC. Material/Methods The HMGB1 gene rs1360485, rs1045411, and rs2249825 site SNPs were genotyped in all participants. The mRNA expression of serum HMGB1 was examined using quantitative reverse transcription-polymerase chain reaction. The correlation of the HMGB1 rs1360485 SNP with NEC neonatal survival prognosis was evaluated by univariate analysis and logistic multivariate regression analysis. Results The TC and CC genotype and C allele distribution frequencies of the rs1360485 SNP were lower in the NEC group, and the differences were statistically significant (all P <0.05). Individuals carrying the TC and CC genotype or C allele had a low risk of being affected by NEC. However, the genotype and allele distributions of rs1045411 and rs2249825 were not significantly different between the patient and control groups ( P >0.05). NEC neonates with HMGB1 gene rs1360485 site mutations had lower mRNA levels of serum HMGB1 than those with rs1360485 site wild-type, and the rs1360485 genotypes TC and CC could independently predict better survival outcomes in NEC neonates. Conclusions This study demonstrated that the rs1360485 SNP of the HMGB1 gene is associated with susceptibility of NEC in neonates, and the rs1360485 genotypes TC and CC may affect HMGB1 expression and are associated with the survival prognosis of neonates with NEC.

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“…High-mobility group protein B1 (HMGB1), which plays an important role in the activation of transcription factor signalling pathways, has been identified to be involved in the occurrence and development of a variety of tumours, including non-small-cell lung, cervical, and colorectal cancer (11). Moreover, an increasing number of studies have demonstrated that the overexpression of HMGB1 is related to the poor prognosis of PCa and CRPC (12,13). Although these studies initially demonstrated that HMGB1 was associated with the progression, clinical pathological characteristics, and poor prognosis of PCa, the molecular mechanism by which HMGB1 promotes the development of CRPC remains unclear.…”

Section: Hmgb1 Promotes the Development Of Castration-resistant Prost...mentioning

confidence: 99%

HMGB1 promotes the development of castration‑resistant prostate cancer by regulating androgen receptor activation

Chen

Wang

et al. 2022

Oncol Rep

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AR signalling pathway reactivation plays a key role in the development of castration-resistant prostate cancer (CRPC). High-mobility group protein B1 (HMGB1) is an important factor involved in the occurrence and development of a variety of tumours by regulating gene transcription. In the present study, the association between HMGB1 and prostate cancer (PCa) and the effects of HMGB1 on androgen receptor (AR) transcription and signalling pathway reactivation in PCa cells in vitro and in vivo were evaluated. A bioinformatics method was used to determine the mRNA expression level of HMGB1 in PCa specimens and its correlation with the mRNA expression of AR. Immunohistochemical staining was used to detect the expression of these proteins in clinical PCa samples. Reporter gene and ChIP assays were performed to determine the activity of AR and the effect of HMGB1 on the ability of AR to bind to the promoters of prostate specific antigen and transmembrane protease, serine 2. A bioluminescence resonance energy transfer assay was employed to observe the direct interaction between HMGB1 and AR protein. Additionally, a castrated nude mouse xenograft tumour model was established to verify the effect of HMGB1 on PCa. The results revealed that HMGB1 expression was significantly increased in PCa specimens, which may have a strong correlation with AR expression. Moreover, HMGB1 could reactivate the AR signalling pathway, directly interact with AR, and promote the development of CRPC in an androgen-independent manner. The results of the present study indicated that HMGB1 promoted the development of CRPC by interacting with AR, which inferred that decreasing the expression of HMGB1 may be a potential effective method for CRPC prevention and treatment.

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The Impact of HMGB1 Polymorphisms on Prostate Cancer Progression and Clinicopathological Characteristics

Cited by 8 publications

References 53 publications

High‐mobility group box 1 emerges as a therapeutic target for asthma

High‐mobility group box 1 emerges as a therapeutic target for asthma

Association of High-Mobility Group Box 1 (HMGB1) Gene Polymorphisms with Susceptibility and Better Survival Prognosis in Chinese Han Neonatal Necrotizing Enterocolitis

HMGB1 promotes the development of castration‑resistant prostate cancer by regulating androgen receptor activation

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