The Impact of HIV Status and Type on the Clearance of Human Papillomavirus Infection among Senegalese Women

Rowhani-Rahbar, Ali; Hawes, Stephen E.; Sow, Papa Salif; Touré, Papa Souleymane; Feng, Qinghua; Dem, Ahmadou; Dembélé, Birama; Critchlow, Cathy W.; N'Doye, Ibraham; Kiviat, Nancy B.

doi:10.1086/520883

Cited by 83 publications

(72 citation statements)

References 29 publications

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“…Nevertheless, CD4 counts are not the only factor involved in persistent HPV infection with HIV infection. 7,8 We recognize that our study has limitations. Because study participants were either HIV infected or were at high-risk for HIV infection, our findings cannot be extended to the general population.…”

Section: Discussionmentioning

confidence: 94%

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Human papillomavirus type 16 (HPV-16) viral load and persistence of HPV-16 infection in women infected or at risk for HIV

Fontaine

Hankins

Money

et al. 2008

Journal of Clinical Virology

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Section: Discussionmentioning

confidence: 94%

“…4-7 HIV infection reduces the likelihood of HPV clearance. 6,[8][9][10][11] Persistence of highrisk HPV type infections is a risk factor for CIN-2,3. 6,[12][13][14] Several studies suggest that HPV viral load could be a predictor for SIL in HIV-seronegative [15][16][17][18][19] and HIV-seropositive women.…”

Section: Introductionmentioning

confidence: 99%

Human papillomavirus type 16 (HPV-16) viral load and persistence of HPV-16 infection in women infected or at risk for HIV

Fontaine

Hankins

Money

et al. 2008

Journal of Clinical Virology

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“…Worldwide, more than 10‐fold differences are being reported in HPV prevalence5 mainly related to differences in sexual activity patterns and, in some regions, to the prevalence of human immunodeficiency virus (HIV), which is associated with increased acquisition6 and persistence7 of HPV infection.…”

Section: Introductionmentioning

confidence: 99%

Impacts of human papillomavirus vaccination for different populations: A modeling study

Baussano

Lazzarato

Ronco³

et al. 2018

Intl Journal of Cancer

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International variations in the prevalence of HPV infection derive from differences in sexual behaviors, which are also a key factor of the basic reproductive number (R0) of HPV infection in different populations. R 0 affects the strength of herd protection and hence the impact of a vaccination program. Similar vaccination programs may therefore generate different levels of impact depending upon the population's pre‐vaccination HPV prevalence. We used IARC's transmission model to estimate (i) the overall effectiveness of vaccination versus no vaccination in women aged 15–34 years measured as percent prevalence reduction (%PR) of HPV16 and (ii) the corresponding herd protection in populations with gender‐equal or traditional sexual behavior and with different levels of sexual activity, corresponding to pre‐vaccination HPV16 prevalence from 1 to 8% as observed worldwide. Between populations with different levels of gender‐equal sexual activity, the highest difference in %PR under girls‐only vaccination is observed at 40% coverage (91%PR vs. 48%PR for 1% and 8% pre‐vaccination prevalence, respectively). HPV16 elimination is obtained with 55 and 97% coverage, respectively. To achieve desirable levels of HPV16 prevalence after vaccination, different levels of coverage are required in populations with different levels of pre‐vaccination HPV16 prevalence, for example, in populations with gender‐equal sexual behavior a decrease to 1/1000 HPV16 from pre‐vaccination prevalence of 1 and 8% would require coverages of 37 and 96%, respectively. In traditional populations, corresponding coverages would need to be 28 and 93%, respectively. In conclusion, pre‐vaccination HPV prevalence strongly influences herd immunity and helps predict the overall effectiveness of HPV vaccination.

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“…Immunosuppression is a risk factor for HPV infection and/or detection, and there is consistent evidence that HIV-positive women have higher prevalence of HPV infection, more persistent infection, and resulting higher rates of preinvasive cervical lesions (1,2,6,7,(13)(14)(15). However, the evidence is mixed for an increased risk of invasive cervical cancer (ICC) associated with HIV (1, 13).…”

Section: Introductionmentioning

confidence: 99%

HIV Infection as a Risk Factor for Cervical Cancer and Cervical Intraepithelial Neoplasia in Senegal

Holmes

Hawes

Touré

et al. 2009

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Cervical cancer is the second leading cause of cancer mortality in women worldwide, and the leading cause in Africa. There is uncertainty in the role of HIV infection as a risk factor for invasive and preinvasive cervical lesions, particularly in African populations. In a casecontrol study in Dakar, Senegal, we studied 150 women with invasive cervical cancer (ICC), 92 with cervical intraepithelial neoplasia (CIN) 2 or 3, 70 with CIN 1, and 515 control women. We used logistic regression analysis to estimate associations between HIV-1 and HIV-2 infection and the risk of cervical neoplasia. We found large increases in the risk of ICC and CIN 2-3, but not of CIN 1, associated with the presence of either HIV-1 or HIV-2 infection (odds ratios of 6.5 and 10.4 for ICC and CIN 2-3). Our analysis thus shows increases in the risk of both advanced and early cervical pathology associated with HIV infection in an African population.

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The Impact of HIV Status and Type on the Clearance of Human Papillomavirus Infection among Senegalese Women

Abstract: HIV infection reduces the likelihood of HPV clearance. Among HIV-positive women, immunosuppression, as measured by CD4 cell count, reduces the likelihood of HPV clearance, and HIV type appears to be associated with HPV clearance.

Cited by 83 publications

References 29 publications

Human papillomavirus type 16 (HPV-16) viral load and persistence of HPV-16 infection in women infected or at risk for HIV

Human papillomavirus type 16 (HPV-16) viral load and persistence of HPV-16 infection in women infected or at risk for HIV

Impacts of human papillomavirus vaccination for different populations: A modeling study

HIV Infection as a Risk Factor for Cervical Cancer and Cervical Intraepithelial Neoplasia in Senegal

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