The impact of HF-rTMS treatment on serotonin2A receptors in unipolar melancholic depression

Baeken, Chris; Raedt, Rudi De; Bossuyt, Axel; Hove, Christian Van; Mertens, John; Dobbeleir, André; Blanckaert, Peter; Goethals, Ingeborg

doi:10.1016/j.brs.2010.09.002

Cited by 75 publications

(44 citation statements)

References 50 publications

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“…Serotonin receptors such as the post-synaptic 5-HT2A receptor located in the amygdala and hippocampus regulate the HPA-system during stress (Leonard, 2005). In a recent study, examining the effect of left DLPFC HFrTMS treatment on 5-HT2A receptor binding indices in medication-resistant depressed patients we found a significant hippocampal 5-HT2A receptor down-regulation only when treatment was clinically successful (Baeken et al, 2011b). …”

Section: Discussion Discussion Discussion Discussionmentioning

confidence: 94%

One left dorsolateral prefrontal cortical HF-rTMS session attenuates HPA-system sensitivity to critical feedback in healthy females

Baeken¹,

Vanderhasselt²,

Remue³

et al. 2014

Neuropsychologia

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Abstract Abstract 2Objective: Although left dorsolateral prefrontal cortical (DLPFC) repetitive Transcranial Magnetic Stimulation (rTMS) is used to treat major depression, its underlying neurophysiological working mechanism remains to be determined. Prior research suggested that the clinical effects could be mediated by affecting the hypothalamic-pituitary-adrenal (HPA) system, but experimental studies in healthy individuals did not yield clear results. However, in healthy individuals, the influence of HFrTMS on the HPA-system may only be detected when it is challenged.Methods: In 30 rTMS naïve healthy females we evaluated the effect of one sham-controlled high frequency (HF)-rTMS session applied to the left DLPFC on the stress hormone cortisol by collecting salivary cortisol samples. In order to increase stress levels, five minutes after stimulation, all participants performed the Critical Feedback Task (CFT), during which they were criticized on their performance. To take possible mood influences into account, all participants were also assessed with Visual Analogue Scales (VAS).Results: The experimental procedure did not affect mood differently in the real or sham stimulation.Area under the curve (AUCi) analysis showed that one real HF-rTMS session significantly influenced HPA-system sensitivity, as demonstrated by a decrease in cortisol concentrations. The sham procedure yielded no effects.Conclusions: In line with former observations in major depression, one real left DLPFC HF-rTMS session significantly influenced HPA-system sensitivity in experimentally stressed females, resulting in decreases in cortisol levels.

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Section: Discussion Discussion Discussion Discussionmentioning

confidence: 94%

One left dorsolateral prefrontal cortical HF-rTMS session attenuates HPA-system sensitivity to critical feedback in healthy females

Baeken¹,

Vanderhasselt²,

Remue³

et al. 2014

Neuropsychologia

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“…In other words, for each female or male TRD patient a suitable female or male ADN patient and healthy control was selected, matched for age as close as possible. Parts of the TRD patient and the control SPECT data were also used for another study, examining the treatment effects of high frequency repetitive transcranial magnetic stimulation in these kinds of patients (Baeken et al 2011 Patients with substance abuse/dependence were not included in the study. Because in post-mortem studies increased 5-HT 2(A) receptor BI are reported in the frontal cortices of suicide victims , suicidal attempts during the current depressive episode were considered as an exclusion criterion.…”

Section: Subjectsmentioning

confidence: 99%

Is treatment-resistance in unipolar melancholic depression characterized by decreased serotonin2A receptors in the dorsal prefrontal – Anterior cingulate cortex?

2012

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Objectives: Quite a number of patients diagnosed with major depression are resistant to several well carried-out psychopharmacological interventions. It remains unclear as to how the serotonergic system is implicated in the phenomenon of treatment-resistance. regulated. However, whether this assumed underlying pathophysiological mechanism is due solely to abnormalities in the serotonergic system remains to be answered.3

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“…The modulation of neuronal activity by increasing or decreasing cortical excitability is the main effect of rTMS in an applied region. Moreover, neuroplasticity, modulation in the secretion of endogenous dopamine, and some neurotrophic factors, like brain-derived neurotrophic factor and an alteration of serotonergic and dopaminergic receptor levels, are likely the main components that are involved in the rTMS' mechanisms of action [10][11][12][13]. Although there are some reports determining the association between rTMS and brain regions (like the prefrontal cortex and amygdala) that are considered to be relevant to the pathophysiology of anxiety and depression, current studies investigating the therapeutic effects of rTMS in the treatment of anxiety disorders are unsatisfactory and contradictory [14].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of repetitive transcranial magnetic stimulation for treatment-resistant major depression and the impact of anxiety symptoms on outcome

Durmaz

Ebrinç

Ateş

et al. 2017

Psychiatry and Clinical Psychopharmacology

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Objective: The aim of this study was to evaluate the efficacy of repetitive transcranial magnetic stimulation (rTMS) in patients with treatment-resistant major depression and to explore the relationship between the outcome and comorbid anxiety symptoms. Methods: The study was performed on 36 patients with treatment-resistant major depression. Patients received 15 rTMS sessions to their left dorsolateral prefrontal cortex with 110% motor threshold intensity, 20 Hz frequency, and 1000 pulses per day over a three-week period with the same stimulation parameters. Patients were assessed using Sociodemographics Form, the Montgomery-Asberg Depression Rating Scale (MADRS), and the Hamilton Anxiety Rating Scale (HAM-A) at baseline both before initiating rTMS treatment and on the first day following their last rTMS treatment session. Results: Decreased scores in patients' MADRS and HAM-A (including subscales) were statistically significant with large effect sizes (r > 0.5) after rTMS treatment. Pretreatment HAM-A total scores and HAM-A somatic subscale scores were significantly higher in those who responded to rTMS (p = .046, p = .048). There were negative correlations between posttreatment MADRS scores and pretreatment HAM-A somatic and psychic subscale scores. Conclusions: While the main limitations of the study are its design and small sample size, the findings suggested that comorbid anxiety symptoms, particularly somatic anxiety, could predict the response to rTMS in treatment-resistant major depressive disorder. ARTICLE HISTORY

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The impact of HF-rTMS treatment on serotonin2A receptors in unipolar melancholic depression

Cited by 75 publications

References 50 publications

One left dorsolateral prefrontal cortical HF-rTMS session attenuates HPA-system sensitivity to critical feedback in healthy females

One left dorsolateral prefrontal cortical HF-rTMS session attenuates HPA-system sensitivity to critical feedback in healthy females

Is treatment-resistance in unipolar melancholic depression characterized by decreased serotonin2A receptors in the dorsal prefrontal – Anterior cingulate cortex?

Evaluation of repetitive transcranial magnetic stimulation for treatment-resistant major depression and the impact of anxiety symptoms on outcome

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