The impact of hepatitis c virus viremia on renal graft and patient survival: a 9-year prospective study

Mahmoud, Ihab; Elhabashi, Ahmed F; Elsawy, Essam; El-Husseini, Amr; Sheha, G.; Sobh, Mohamed

doi:10.1053/j.ajkd.2003.09.018

Cited by 90 publications

(60 citation statements)

References 30 publications

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“…Initially, studies of short follow-up periods suggested that neither patient nor graft survival was altered after transplantation despite an increase in HCV RNA levels (Lau et al, 1993;Lee et al, 2001;Orloff et al, 1995). In contrast, studies with lengthier follow-up after transplantation have found decreased patient and graft survival in HCV-positive renal transplant recipients (Legendre et al, 1998;Mahmoud et al, 2004;Sezer et al, 2004). Post-transplantation HCV-related liver disease is often progressive in renal transplant recipients.…”

Section: Patient and Graft Survivalmentioning

confidence: 82%

Infectious Complications in Kidney Transplantation

El‐Husseini¹,

Hassan²

2011

After the Kidney Transplant - The Patients and Their Allograft

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Section: Patient and Graft Survivalmentioning

confidence: 82%

Infectious Complications in Kidney Transplantation

El‐Husseini¹,

Hassan²

2011

After the Kidney Transplant - The Patients and Their Allograft

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“…25 Conversely, others document a higher incidence of proteinuria among the viremic group than the nonviremic one. 8,19,26 Regarding the long-term effect of HCV on patient and graft survival, there was no significant difference between the groups. This agrees the majority of published short-term series [27][28][29] and long-term ones.…”

Section: Discussionmentioning

confidence: 99%

“…8,19,26 Regarding the long-term effect of HCV on patient and graft survival, there was no significant difference between the groups. This agrees the majority of published short-term series [27][28][29] and long-term ones. 20,30 Conversely, her short-term 26 and long-term studies 18,23 have demonstrated significantly inferior graft survival in viremic recipients.…”

Section: Discussionmentioning

confidence: 99%

“…7 So, proteinuria has been used as a marker of disease in the renal allograft among anti-HCV positive transplant recipients. 8 A renal thrombotic microangiopathy may be observed in HCV-infected renal transplant recipients, particularly among those with anticardiolipin antibodies. Several reports have suggested an association between HCV infection and posttransplant diabetes mellitus (PTDM), which has a deleterious effect on patient and graft survival, 9 especially in tacrolimus-treated patients .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Untitled

2015

Exp Clin Transplant

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Objectives: Hepatitis C virus infection occurs frequently among end-stage renal disease patients. Moreover, its effect on long-term patient and renal graft survival is controversial. This study was performed to assess the long-term effect of hepatitis C virus on the outcome of kidney allografts Materials and Methods: We retrospectively analyzed 273 hepatitis B negative renal transplant recipients who were transplanted at Mansoura Urology and Nephrology Center, for whom hepatitis C virus RNA polymerase chain reaction results were available before transplant, and followed them for at least 17 years after transplant. We compared graft and patient survival rates between viremic group (study group) and nonviremic group (control group). We also studied posttransplant hepatic function, graft performance, and incidence of posttransplant diabetes mellitus. Results: Hepatitis C virus was detected in sera of 195 patients (71%). No statistically significant increased risk for graft failure (P = .29) or patient death (P = .47) was found among the groups. Hepatitis C virus viremic transplant recipients had significantly greater frequencies of biochemical chronic liver disease (P = .01). However, we did not report significant differences regarding incidence, quantity of proteinuria, biopsy-proven acute rejection, chronic allograft nephropathy, and incidence of posttransplant diabetes mellitus between the studied groups. Conclusions: Hepatitis C virus infection was shown to increase the incidence of chronic hepatitis posttransplant. However, no statistically significant adverse effect on long-term renal graft and patient survival was noted.

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“…The use of a HCV positive donor was not a risk factor for mortality, graft loss or advanced liver disease in this study. Mahmoud and colleagues demonstrated an increased incidence of transplant glomerulopathy among HCV positive renal transplant recipients [62].…”

Section: Outcomes Following Transplantationmentioning

confidence: 99%