The impact of hepatic steatosis on liver regeneration after partial hepatectomy

Abstract

Although early RI after PH did not differ in patients with or without steatosis, the late RI in patients with moderate-to-severe steatosis was lower, suggesting that late liver regeneration is impaired in these patients.

Is the liver kinetic growth rate in ALPPS unprecedented when compared with PVE and living donor liver transplant? A multicentre analysis

“…What direct effect this may have had on hepatic regeneration is not yet clear. 26 It is interesting to note that the ALPPS patients demonstrated a higher degree of hypertrophy than the LD-recipient group, who obviously had more comorbidities than the LD donor group. In addition, LD recipients received post-operative immunosuppression that may have effects on liver regeneration.…”

“…Conversely, patients in the ALPPS and PVE groups frequently had an impaired performance status and had undergone pre‐operative chemotherapy and therefore their livers probably had some degree of injury. What direct effect this may have had on hepatic regeneration is not yet clear . It is interesting to note that the ALPPS patients demonstrated a higher degree of hypertrophy than the LD‐recipient group, who obviously had more comorbidities than the LD donor group.…”

Nonalcoholic fatty liver disease impairs expression of the type II inositol 1,4,5‐trisphosphate receptor

“…NAFLD also results in other specific liver problems, including impaired liver regeneration (LR). (2,3) Although weight loss (4) and exercise (5) can be beneficial in NASH, the value of pharmacological treatments is less established. (6) Therefore, an improved Abbreviations: ALP, alkaline phosphatase; ALT, alanine aminotransferase; AP-1, activator protein-1; ATP, adenosine triphosphate; bp, base pairs; BrdU, 5-bromo-2 0 -deoxyuridine; BSA, bovine serum albumin; EdU, 5-ethynyl-2 0 -deoxyuridine; EGF, epidermal growth factor; HCC, hepatocellular carcinoma; H&E, hematoxylin-eosin; HFFD, high-fat, high-fructose diet; HGF, hepatocyte growth factor; IACUC, Institutional Animal Care and Use Committee; Il-6, interleukin-6; ITPR, inositol 1,4,5-trisphosphate receptor; ITPR1, type I inositol 1,4,5-trisphosphate receptor; ITPR2, type II inositol 1,4,5-trisphosphate receptor; JNK, c-Jun NH 2 -terminal kinase; KO, knockout; LR, liver regeneration; MDA, malondialdehyde; NAFLD, nonalcoholic fatty liver disease; NASH, nonalcoholic steatohepatitis; PCNA, proliferating cell nuclear antigen; PH, partial hepatectomy; siRNA, small interfering RNA; SS, simple steatosis; TNF-a, tumor necrosis factor-alpha; WT, wild-type.…”

Does Simple Steatosis Affect Liver Regeneration after Partial Hepatectomy in Rats?

“…Similar results were found also in humans. Hepatic steatosis impairs liver regeneration as is reflected by the declining regeneration markers in patients with an increasing degree of steatosis (23). Patients with steatosis had an up to two-fold increased risk of postoperative complications, and those with excessive steatosis had an almost threefold increased risk of death after major hepatic resection (24).…”