The impact of hematological malignancies and their treatment on oral health-related quality of life as assessed by the OHIP-14: a systematic review

Stolze, Juliette; Vlaanderen, Kim C. E.; Raber-Durlacher, Judith E.; Brand, H.S.

doi:10.1007/s10266-019-00479-7

Cited by 7 publications

(7 citation statements)

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“…Oral mucosal cGHVD manifestations were mostly mild-to-moderate in nature. As observed by us and others, patients may still report multiple oral cGvHD-related complaints in the absence of visible manifestations [35,36]. According to Sato and coworkers, patient-reported oral cGvHD is a significant predictive factor for taste disorders in alloHSCT recipients 3 months or more post-transplant [9].…”

Section: Discussionmentioning

confidence: 88%

Taste and smell disturbances in patients with chronic oral graft vs. host disease: An observational study

Boor¹,

Raber-Durlacher²,

Hazenberg³

et al. 2022

Front. Oral. Health

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BackgroundA common complication of allogeneic hematopoietic stem cell transplantation (alloHSCT) is chronic oral graft vs. host disease (cGvHD). Oral cGvHD may present as mucosal lesions, salivary gland dysfunction, and trismus. Moreover, taste and smell ability may be affected, but the prevalence, nature and severity of altered taste and smell function, and their impact on quality of life (QoL) are understudied.AimTo identify the prevalence, nature, and severity of taste and smell disturbances, their impact on QoL and to assess whether altered taste/smell ability is associated with oral mucosal cGvHD or hyposalivation.Materials and methodsAlloHSCT recipients at least 100 days post-HSCT and referred for oral cGvHD-related oral complaints were eligible for participation in this cross-sectional study. Manifestations of oral mucosal cGvHD were scored, the (un)stimulated salivary flow was measured, and objective taste and smell ability was evaluated. Subjective taste and smell alterations, and overall and oral health (OH)-related QoL were assessed.ResultsIn total, 45 patients were included, of which objective reduced taste ability (hypogeusia) was identified in 68.9%; 28.9% had reduced smell ability and 11.1% had complete loss of smell. Nevertheless, only 31.1% of patients reported severe taste alterations and 22% reported moderate taste alterations indicating that not all the patients were aware of their altered taste sense. Taste/smell disturbances were not related to oral mucosal cGvHD or hyposalivation. Most alloHSCT recipients reported a decreased OH-related QoL. However, a relation between taste/smell ability and global or OH-related QoL could not be identified.ConclusionTaste and smell disturbances are prevalent among alloHSCT recipients. Most patients reported a decreased OH-related QoL, but the specific impact of taste and smell disturbances remains to be elucidated.

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Section: Discussionmentioning

confidence: 88%

Taste and smell disturbances in patients with chronic oral graft vs. host disease: An observational study

Boor¹,

Raber-Durlacher²,

Hazenberg³

et al. 2022

Front. Oral. Health

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“…However, in a study among children having survived childhood cancer, the type of cancer and its treatment were not associated with a decreased OHRQoL compared to children without a cancer history [ 11 ]. A recent review [ 22 ] on OHRQoL in children and adult patients with a hematological malignancy reported that functional limitations because of problems with oral mucosal tissues, the dentition, or dentures, seem to have a larger negative impact on the OHRQoL than social aspects associated with oral health problems. Similar to that review, in the present study, the questions in the domain of physical pain were given the highest scores (Figure 3 , Table S1 ).…”

Section: Discussionmentioning

confidence: 99%

Self-reported outcomes on oral health and oral health-related quality of life in long-term childhood cancer survivors—A DCCSS-LATER 2 Study

Stolze,

Raber-Durlacher,

Loonen

et al. 2023

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Purpose The present study aimed to determine the prevalence of self-reported oral problems and the oral health–related quality of life (OHRQoL) in childhood cancer survivors (CCS). Methods Patient and treatment characteristics of CCS have been collected in a cross-sectional study, part of the multidisciplinary DCCSS-LATER 2 Study. To assess self-reported oral health problems and dental problems, CCS filled out the ‘Toegepast-Natuurwetenschappelijk Onderzoek’ (TNO) oral health questionnaire. OHRQoL was assessed by the Dutch version of the Oral Health Impact Profile-14 (OHIP-14). Prevalences were compared with two comparison groups from the literature. Univariable and multivariable analyses were performed. Results A total of 249 CCS participated in our study. The OHIP-14 total score had a mean value of 1.94 (sd 4.39), with a median score of 0 (range 0–29). The oral problems ‘oral blisters/aphthae’ (25.9%) and ‘bad odor/halitosis’ (23.3%) were significantly more often reported in CCS than in comparison groups (12% and 12%, respectively). The OHIP-14 score was significantly correlated with the number of self-reported oral health problems (r = .333, p<0.0005) and dental problems (r = .392, p <0.0005). In multivariable analysis, CCS with a shorter time since diagnosis (10-19 years vs. ≥30 years) had a 1.47-fold higher risk of ≥1 oral health problem. Conclusion Though the perceived oral health is relatively good, oral complications following childhood cancer treatment are prevalent in CCS. This underlines that attention to impaired oral health and awareness on this topic is mandatory and regular visits to the dentist should be a part of long-term follow-up care.

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“…To assess the OHRQoL, patients were asked to complete the Dutch version of the Oral Health Impact Profile-14 (OHIP-14). The OHIP-14 comprises 14 items that measure seven domains of impact on patients OHRQoL: functional limitation, physical pain, psychological discomfort, physical disability, psychological disability, social disability, and social handicap [25,26]. For each item of the OHIP-14, a 5-point Likert scale is used ranging from 0 "never" to 4 "very often" according to the frequency of the impact.…”

Section: Ohrqol Assessmentmentioning

confidence: 99%

Oral health–related quality of life of patients with oral chronic graft-versus-host disease

Stolze

Boor

Hazenberg

et al. 2021

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Purpose Symptoms of oral chronic graft-versus-host-disease (cGVHD) may significantly affect the oral health–related quality of life (OHRQoL). This study aimed to assess the OHRQoL in patients with oral cGVHD and to examine whether oral cGVHD symptoms, mucosal cGVHD, and salivary gland function correlated with OHRQoL. Methods Patients referred to the oral cGVHD outpatient clinic were included. Severity of oral mucosal cGVHD, oral cGVHD symptoms, and OHRQoL was assessed by the NIH OMS, NIH OSS, and OHIP-14, respectively. Unstimulated and stimulated whole salivary flow rates were determined and categorized into “hyposalivation,” “normal salivary flow,” and “hypersalivation.” Results Of 56 included patients, 80% had mild, moderate, or severe oral mucosal cGVHD. Mean total score of OHRQoL was 16.5 (±11.7), negatively affected by functional problems. Patients reported highest scores regarding oral sensitivity and xerostomia. Significant correlations were found between severity of oral pain and OHRQoL and between oral sensitivity and OHRQoL. No correlation was found between oral mucosal cGVHD and OHRQoL. Patients with hyposalivation, normal salivary flow, and hypersalivation reported equal levels of OHRQoL. Conclusion Results demonstrate that the OHRQoL was mostly negatively affected by complaints of oral pain and oral sensitivity and less by the severity of oral mucosal cGVHD assessed by the NIH OMS score. Special attention of (oral) health care professionals for patients with oral cGVHD is mandatory to alleviate their symptoms and improve OHRQoL.

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The impact of hematological malignancies and their treatment on oral health-related quality of life as assessed by the OHIP-14: a systematic review

Cited by 7 publications

References 28 publications

Taste and smell disturbances in patients with chronic oral graft vs. host disease: An observational study

Taste and smell disturbances in patients with chronic oral graft vs. host disease: An observational study

Self-reported outcomes on oral health and oral health-related quality of life in long-term childhood cancer survivors—A DCCSS-LATER 2 Study

Oral health–related quality of life of patients with oral chronic graft-versus-host disease

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