The impact of headache on quality of life

Impact of Prolonged-release Oxycodone/Naloxone on Outcomes Affecting Patients' Daily Functioning in Comparison With Extended-release Tapentadol: A Systematic Review

“…Improvements in AEs associated with opioids can have a significant effect on the daily functioning of patients, and improvements in symptoms such as constipation, dizziness, and headache may therefore lead to an associated increase in HRQoL in patients. 7,11,42 The findings from this NMA indicated that oxycodone/naloxone was significantly better than all other treatments included in the NMA, including tapentadol, with respect to the patient-reported constipation measure PAC-SYM total score. A common symptom for patients treated with opioids is OIBD, in particular constipation, which has a significant effect on QoL; therefore, improvements in constipation with oxycodone/naloxone, as indicated in this NMA by a reduction in PAC-SYM total score compared with tapentadol, may translate to significant QoL benefits for patients.…”

“…One key drawback of opioid treatment is the adverse effect (AE) profile, including headache, dizziness, and fatigue, which can affect daily functioning and patient QoL. [7][8][9] Another frequent AE of opioid treatment is opioid-induced bowel dysfunction (OIBD), an umbrella term used to describe the gastrointestinal AEs of opioids, including constipation, hard dry stools, bloating and abdominal distension, and abdominal cramps and spasms. 10 In a multinational, Internet-based study of 322 patients taking daily opioids (PROBE 1), constipation was reported as the most common AE in 81% of patients, and it was considered to be the AE that was most bothersome and most often reported as severe, despite the use of laxatives in all patients.…”

A one-year prospective costing study of botulinum toxin type A treatment of chronic tension headache

“…There is also a dearth of literature focussed on the impact of chronic tension headache on quality of life and working activities. Most of the headache studies that focused on quality of life or loss of productivity relate to the burden of migraine headache [15][16][17][18][19][20]. Studies assessing the potential impact of BTX-A treatment on the economic, societal and quality of life burden of chronic tension headache would be of great interest.…”

Migrende Yaşam Kalitesinin Değerlendirilmesi

“…Yüzaltı migrenlinin EYK-5D skorlarının hizmet yararlanma değerleri incelendiğinde tüm migren ağrısı derecelerinde anlamlı olarak bunun düşük olduğu, migrenin şiddeti arttıkça yararlanmanın düştüğü ve şiddetli migren ağrısının "ölümden bile kötü bir durum" olarak tanımlandığını, ayrıca bu sonuçların, migrenin tedavisiyle bağıntılı ekonomik değerlerinin incelendiği yararlanma maliyet modellerinde kullanılabileceği de bildirilmiştir (65).…”

“…SF-36 ağrılı durumlarda sık kullanıldığı gibi migrenlilerde de çalışmalarda kullanılmıştır (60,61,64,65). Hem SF36 hem de kısa formu olan SF12'nin kullanıldığı çalışmalar, migrenlilerde yaşam kalitesinin genel popülasyondan da diğer kronik hastalıklara sahip hastalardan da daha kötü olduğunu göstermiştir Migrenlilerde skorlarındaki en büyük düşüşlerin rol kısıtlılığı, sosyal fonksiyon ve vücut ağrısı ile ilgili alanlarda olduğu bulunmuştur (61).…”