The occurrence of significant incidents in academic and professional laboratories indicates insufficient methods for ensuring effective and safe performance of protocols. Using written standard operating procedures (SOPs) is one method that could improve this situation. Although there are currently numerous guidelines regarding the necessary content for SOPs, there is a dearth of information regarding how these SOPs should be written and designed. Human Factors/Ergonomics principles and guidelines can provide insight and guidance regarding writing SOPs that are more likely to result in safe and accurate performance by the user. This paper presents some guidance for developing procedures for those who regularly perform laboratory protocols and resources for more guidance.