The impact of Hayward green kiwifruit on dietary protein digestion and protein metabolism

Park, Sanghee; Church, David D.; Starck, Carlene; Schutzler, Scott; Azhar, Gohar; Kim, Il‐Young; Ferrando, Arny A.; Moughan, Paul J.; Wolfe, Robert R.

doi:10.1007/s00394-020-02363-5

Cited by 8 publications

(7 citation statements)

References 17 publications

(27 reference statements)

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“…Blood and muscle samples were analyzed for isotope enrichment using methods previously described (Park et al, 2021 ). Briefly, upon thawing, biopsy samples were precipitated with 800 µl of 14% perchloroacetic acid.…”

Section: Methodsmentioning

confidence: 99%

Perioperative amino acid infusion reestablishes muscle net balance during total hip arthroplasty

et al. 2021

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Surgery and anesthesia induce a catabolic response that leads to skeletal muscle protein loss. Previous investigations have observed positive effects of perioperative nutrition. Furthermore, the benefits of exogenous amino acids on muscle protein kinetics are well established. However, no investigation has focused on muscle protein kinetics with and without perioperative amino acid infusion. Thus, we aimed to assess the effect of perioperative amino acid (AA) infusion on muscle protein balance in individuals undergoing elective total hip arthroplasty (THA). Elective THA patients were randomized to undergo a metabolic study prior to surgery ( n = 5; control [CON]), intraoperative AA infusion ( n = 9), or no AA ( n = 13; standard of care [SC]). The CON group was studied prior to surgery to provide nonoperative/non‐anesthesia muscle protein kinetic reference values. The bolus infusion method with 13 C 6 ‐phenylalanine injected at time 0, and [ 15 N]‐phenylalanine 30 min later was used to calculate muscle protein synthesis (MPS), protein breakdown (MPB), and net balance (MPS−MPB). Perioperative AA significantly improved muscle net balance as compared to SC (−0.005 ± 0.018%/h vs. −0.052 ± 0.011%/h) but not CON (0.003 ± 0.013%/h). The AA infusion significantly increased muscle net balance via a significant increase in MPS (AA = 0.062 ± 0.007%/h; SC = 0.037 ± 0.004%/h; CON = 0.072% ± 0.005%/h), and a nonsignificant attenuation of MPB (AA = 0.067 ± 0.012%/h; SC = 0.089 ± 0.014%/h; CON = 0.075 ± 0.011%/h). Our data support the use of perioperative AA infusion during elective THA as pragmatic strategy to offset the loss of surgically induced skeletal muscle protein.

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Section: Methodsmentioning

confidence: 99%

Perioperative amino acid infusion reestablishes muscle net balance during total hip arthroplasty

et al. 2021

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“…Alterations in rates of polymer synthesis such as protein [ 26 , 58 ], DNA [ 59 , 60 ], RNA [ 59 , 61 ], triacylglycerol [ 62 , 63 ], and glucose (e.g., GNG) [ 64 , 65 ], from their respective precursors have clinical implications [ 66 , 67 ]. In this regard, the tracer incorporation model has been widely used to obtain the polymer synthesis rate and is predicated on the rate of tracer precursor incorporation to product for a given time period, yielding the fractional synthesis rate (FSR), which refers to the percent of the pool size that has been newly synthesized from the precursor for the most recent defined time period (%/time) [ 68 ].…”

Section: Basic Principles Of Stable Isotope Tracer Methodologymentioning

confidence: 99%

In Vivo and In Vitro Quantification of Glucose Kinetics: From Bedside to Bench

Kim¹,

Park²,

Kim³

et al. 2020

Endocrinol Metab

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Like other substrates, plasma glucose is in a dynamic state of constant turnover (i.e., rates of glucose appearance [Ra glucose] into and disappearance [Rd glucose] from the plasma) while staying within a narrow range of normal concentrations, a physiological priority. Persistent imbalance of glucose turnover leads to elevations (i.e., hyperglycemia, Ra>Rd) or falls (i.e., hypoglycemia, Ra<Rd) in the pool size, leading to clinical conditions such as diabetes. Endogenous Ra glucose is divided into hepatic glucose production via glycogenolysis and gluconeogenesis (GNG) and renal GNG. On the other hand, Rd glucose, the summed rate of glucose uptake by tissues/organs, involves various intracellular metabolic pathways including glycolysis, the tricarboxylic acid (TCA) cycle, and oxidation at varying rates depending on the metabolic status. Despite the dynamic nature of glucose metabolism, metabolic studies typically rely on measurements of static, snapshot information such as the abundance of mRNAs and proteins and (in)activation of implicated signaling networks without determining actual flux rates. In this review, we will discuss the importance of obtaining kinetic information, basic principles of stable isotope tracer methodology, calculations of in vivo glucose kinetics, and assessments of metabolic flux in experimental models in vivo and in vitro.

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“…Contrary to protein food sources, dietary EAAs do not require digestion before appearing in the circulation, thus inducing rapid and complete appearance rates of EAAs in the circulation. Previous studies have shown that the rate of plasma EAA appearance varies depending on amino acid sources [39][40][41], and the speed of the digestion significantly influences the magnitude of MPS [42]. For example, free EAAs are rapidly absorbed, which leads to higher peak concentrations of plasma EAAs and greater stimulation of MPS compared to casein, whey, or ground beef [38,39,43].…”

Section: Role Of Plasma Eaa Appearance Rate On Stimulation Of Mpsmentioning

confidence: 99%

“…Katsanos et al found that older adults, unlike young subjects, had limited responsiveness of MPS to a composition of dietary EAAs containing 26% of leucine, which is overcome by increasing the leucine content to 41% [31]. Additionally, although not an EAA, specific NEAAs such as arginine and citrulline can augment the MPS response to EAA supplementation [41] through various mechanisms, including improvement in muscle blood flow due to stimulation of nitric oxide production [51]. For example, arginine is the direct precursor of nitric oxide, a potent vasodilator, and its bioavailability in the blood is more effectively increased when citrulline is consumed compared to isonitrogenous arginine due to extensive consumption of arginine by the liver.…”

Section: Compositionmentioning

confidence: 99%

Prevention of Loss of Muscle Mass and Function in Older Adults during COVID-19 Lockdown: Potential Role of Dietary Essential Amino Acids

Park

Chang

Wolfe

et al. 2022

IJERPH

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As the COVID-19 pandemic became a global emergency, social distancing, quarantine, and limitations in outdoor activities have resulted in an environment of enforced physical inactivity (EPI). A prolonged period of EPI in older individuals accelerates the deterioration of skeletal muscle health, including loss of muscle mass and function, commonly referred to as sarcopenia. Sarcopenia is associated with an increased likelihood of the progression of diabetes, obesity, and/or depression. Well-known approaches to mitigate the symptoms of sarcopenia include participation in resistance exercise training and/or intake of balanced essential amino acids (EAAs) and high-quality (i.e., containing high EEAs) protein. As the pandemic situation discourages physical exercise, nutritional approaches, especially dietary EAA intake, could be a good alternative for counteracting against EPI-promoted loss of muscle mass and function. Therefore, in the present review, we cover (1) the impact of EPI-induced muscle loss and function on health, (2) the therapeutic potential of dietary EAAs for muscle health (e.g., muscle mass and function) in the EPI condition in comparison with protein sources, and finally (3) practical guidelines of dietary EAA intake for optimal anabolic response in EPI.

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The impact of Hayward green kiwifruit on dietary protein digestion and protein metabolism

Cited by 8 publications

References 17 publications

Perioperative amino acid infusion reestablishes muscle net balance during total hip arthroplasty

Perioperative amino acid infusion reestablishes muscle net balance during total hip arthroplasty

In Vivo and In Vitro Quantification of Glucose Kinetics: From Bedside to Bench

Prevention of Loss of Muscle Mass and Function in Older Adults during COVID-19 Lockdown: Potential Role of Dietary Essential Amino Acids

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