The impact of H. pylori and/or T. gondii infection on recurrence of gastritis and gastric ulcer

Elawamy, Waleed E.; Ghazy, Amany A.; Haydara, Ahmed; Taha, Ahmed

doi:10.21608/puj.2021.96310.1134

Cited by 3 publications

(4 citation statements)

References 24 publications

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“…However, when examining the relationship between the titer of Toxoplasma antibodies and the stage of chronic inflammation ( r = 0.167, P = 0.395) as well as the degree of activity ( r = 0.103, P = 0.600), no statistically significant association was seen for either variable. The findings of this study were incongruent with the research conducted by Ghazy et al [ 16 ] since their study demonstrated a positive correlation between the severity of gastritis cases and elevated levels of serum anti- Toxoplasma IgG.…”

Section: Discussioncontrasting

confidence: 99%

“…The present study’s findings indicate that among a cohort of 31 individuals who were simultaneously infected with both H. pylori and T. gondii , a substantial majority (80.6%) experienced gastritis of moderate to severe intensity. The results were in line with Ghazy et al [ 16 ].…”

Section: Discussionsupporting

confidence: 93%

“…The observed correlation can be attributed to the fecal-oral route, a frequently seen infection pathway for both pathogens. The elevated rates of H. pylori discovery in feline fecal samples have prompted consideration of potential zoonotic transmission of these infections [ 6 , 16 ].…”

Section: Discussionmentioning

confidence: 99%

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Effect of concurrent infection of Helicobacter pylori with Toxoplasma gondii infection on gastric pathology

Gouda,

Saied,

Edrees

et al. 2024

BMC Infect Dis

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Background Toxoplasma gondii (T. gondii) and Helicobacter pylori (H. pylori) are among the most prevalent foodborne parasitic and bacterial infections worldwide. However, the concurrent impact of coinfection on gastric pathology has yet to be studied in depth. The effect of coinfection generally either adds a synergetic or antagonistic impact; we aimed in the current work to assess the impact of T. gondii coinfection on the progression of H. pylori-associated gastric pathology and reporting H. pylori virulent strains. The study was conducted on 82 patients complaining of persistent gastrointestinal symptoms with failed treatment response and prone to endoscopy. They were subjected to stool examination to detect H. pylori antigen, serological screening for latent toxoplasmosis, endoscopy, histopathological examination, and molecular detection of H. pylori virulence strains in gastric biopsies. Out of the 82 patients, 62 patients were positive for H. pylori antigen in stool and 55 patients confirmed positivity by histopathology; out of them, 37 patients had isolated Vac As1 variants, 11 patients had combined Vac As1 and Cag A variants, and 7 patients had combined Vac As1, Cag A and VacAs2 variants. Patients with the combined two or three variances showed significantly deteriorated histopathological features than patients with a single Vac As1 variant (P < 0.05). Latent toxoplasmosis was positive among 35/82 patients. Combined H. pylori and Toxoplasma gondii infection had significantly marked inflammation than patients with isolated infection (P < 0.05). Conclusion: Screening for toxoplasmosis among H. pylori-infected patients is recommended as it is considered a potential risk factor for gastric inflammation severity. H. pylori gastric inflammation may be heightened by Toxoplasma coinfection.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 93%

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Effect of concurrent infection of Helicobacter pylori with Toxoplasma gondii infection on gastric pathology

Gouda,

Saied,

Edrees

et al. 2024

BMC Infect Dis

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“…It is frequently acquired during childhood and persists throughout the patient's life (Román‐Román et al, 2019). Persistent colonization of the gastric mucosa may progress to peptic ulcer disease (PUD) and/or gastric cancer due to chronic inflammation, mucosal damage, ulceration and transformation of the gastric mucosa to metaplastic or dysplastic epithelial (Ghazy et al, 2021; Román‐Román et al, 2019; Ryberg et al, 2013; Saribas et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Association of human leukocyte antigen DQ-rs3920AG genotype with Helicobacter pylori recurrence in Kafrelsheikh, Egypt

Ghazy

Taha

2022

Journal of Applied Microbiology

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Aims:The aim was to evaluate the role of HLA-DP/DQ single-nucleotide polymorphisms (SNPs) in Helicobacter pylori infection in Kafrelsheikh governorate, Egypt. Methods and results:The study enrolled 120 persons; 48 naïve H. pylori-infected patients, 42 relapsers and 30 H. pylori-free controls. Gastroscopy, H. pylori stool antigen, anti-CagA and anti-VacA antibodies were determined. Genotyping of HLA-DPA1rs3077 (A/G) SNP and HLA-DQ-rs3920(A/G) SNP was done using real-time PCR. The antibody profile against H. pylori showed that 85.7% of patients with recurrent infection have IgG against CagA (p = 0.001*). There was a significant association between the occurrence of H. pylori infection and both HLA-DPA1rs3077AA and HLA-DQ-rs3920AG genotypes. Concerning H. pylori relapse, the HLA-DQ-rs3920AG genotype was detected in 78.6% of patients with recurrent infection (p = 0.002*).Patients carrying this genotype tend to be relapsers 9.8 times more than patients carrying other genotypes.Conclusions: HLA-DPA1rs3077AA and/or HLA-DQ-rs3920AG genotypes could be risk factors for the occurrence of H. pylori infection. HLA-DQ-rs3920AG genotype is markedly linked to recurrent H. pylori infection.Significance and impact of the study: Host factors as HLA gene polymorphism could be a predisposing factor for susceptibility, recurrence or chronicity of H. pylori and should be studied in different ethnic groups.

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Helicobacter pylori-Toxoplasma gondii interplay with a possible role of IL-10

Elblihy,

El-Ghannam,

Mohamed

et al. 2024

Acta Tropica

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The impact of H. pylori and/or T. gondii infection on recurrence of gastritis and gastric ulcer

Cited by 3 publications

References 24 publications

Effect of concurrent infection of Helicobacter pylori with Toxoplasma gondii infection on gastric pathology

Effect of concurrent infection of Helicobacter pylori with Toxoplasma gondii infection on gastric pathology

Association of human leukocyte antigen DQ-rs3920AG genotype with Helicobacter pylori recurrence in Kafrelsheikh, Egypt

Helicobacter pylori-Toxoplasma gondii interplay with a possible role of IL-10

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