The impact of gut microbiota on kidney function and pathogenesis

Mahmoodpoor, Fariba; Saadat, Yalda Rahbar; Barzegari, Abolfazl; Ardalan, Mohammadreza; Vahed, Sepideh Zununi

doi:10.1016/j.biopha.2017.06.066

Cited by 133 publications

(101 citation statements)

References 84 publications

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“…Gut-kidney crosstalk, which is largely affected by the gut microbiota, plays an integral role in the development of CKD with reciprocal interactions [25]. The gut microbiota manipulates the processes leading to CKD through inflammatory [25], endocrine [20], and neurologic pathways [90]; a healthy gut microbiota protects the CKD, whereas gut dysbiosis contributes to the development of CKD [2]. In fact, CKD is associated with alterations in the gut microbiota; species producing uremic toxins, such as Enterobacteriaceae, Clostridiaceae, Pseudomonadaceae, and Bacteroidiaceae, are increased, whereas beneficial species, such as Lactobacillaceae, Bifidobacteriaceae, and Prevotellaceae, are decreased [101][102][103][104].…”

Section: Gut-kidney Crosstalk and Inflammation In The Development Of Ckdmentioning

confidence: 99%

“…The internal homeostasis of the human body largely depends on the interactions between bacteria and human cells, which have a normal composition ratio of 1.3:1 [1]. The gut microbiome is the best represented group [1], with widespread effects on the functioning and pathogenesis of each system of the body, including the renal [2] and cardiovascular [3] systems.…”

Section: Introductionmentioning

confidence: 99%

“…The gut microbiota contributes to the health of the host by protective and trophic functions [6] in addition to aiding host metabolism by synthesizing conjugated linoleic acid [7], amino acids such as lysine [8], vitamin B complex [9], and vitamin K [10] and by facilitating the absorption of complex carbohydrates [11]. Additionally, the gut microbiota communicates with the rest of the body primarily via its interactions with the immune system [12] and its metabolic products, such as uremic toxins [2], oxalate [13], bile acids [14], short-chain fatty acids (SCFAs) [15], nitric oxide (NO) [16], vitamin K [10], vitamin B complex [17], threonine [18], microRNAs (miRNAs) [19], gut hormones [20], neurotransmitters [21], the autonomic nervous system (ANS), and the enteric nervous system (ENS) [22] and through effects on intestinal expression of cannabinoid receptor CB1 [23].…”

Section: Introductionmentioning

confidence: 99%

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Gut microbiota and inflammation in chronic kidney disease and their roles in the development of cardiovascular disease

et al. 2018

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The health and proper functioning of the cardiovascular and renal systems largely depend on crosstalk in the gut-kidney-heart/vessel triangle. Recent evidence suggests that the gut microbiota has an integral function in this crosstalk. Mounting evidence indicates that the development of chronic kidney and cardiovascular diseases follows chronic inflammatory processes that are affected by the gut microbiota via various immune, metabolic, endocrine, and neurologic pathways. Additionally, deterioration of the function of the cardiovascular and renal systems has been reported to disrupt the original gut microbiota composition, further contributing to the advancement of chronic cardiovascular and renal diseases. Considering the interaction between the gut microbiota and the renal and cardiovascular systems, we can infer that interventions for the gut microbiota through diet and possibly some medications can prevent/stop the vicious cycle between the gut microbiota and the cardiovascular/renal systems, leading to a decrease in chronic cardiovascular and renal diseases.

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Section: Gut-kidney Crosstalk and Inflammation In The Development Of Ckdmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Gut microbiota and inflammation in chronic kidney disease and their roles in the development of cardiovascular disease

et al. 2018

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“…In this respect, protein [3] and fiber [4][5][6] intakes are fundamental tools in the dietary control of these risk factors. Some hints do exist pointing to the importance of gut microbiota balance in the prevention of renal function decline [7] with fibres playing a primary role in the modulation of microbial metabolism. In 3 of 22 [7,25].…”

Section: Introductionmentioning

confidence: 99%

“…Some hints do exist pointing to the importance of gut microbiota balance in the prevention of renal function decline [7] with fibres playing a primary role in the modulation of microbial metabolism. In 3 of 22 [7,25]. Again, an adequate fiber intake within a balanced diet is fundamental in maintaining a healthy gut metabolism and promoting intestinal wellness.…”

Section: Introductionmentioning

confidence: 99%

Nutrients, Nutraceuticals and Xenobiotics Affecting Renal Health

Cosola

Sabatino

Bari

et al. 2018

Preprint

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Abstract:Chronic kidney disease (CKD) affects worldwide 8-16% of the population. In developed countries, the most important risk factors for CKD are diabetes, hypertension and obesity, calling into question the importance of educating and acting on lifestyles and nutrition. A balanced nutrition and supplementation can indeed support the maintenance of a general health status, including preservation of renal function, and help to manage and curb the main risk factors for renal damage. While the concepts of protein and salt restriction in nephrology are historically acknowledged, the role of some nutrients on renal health and the importance of nutrition as a preventative measure for renal care are less known.In this review, we provide an overview of the demonstrated and potential actions of some selected nutrients, nutraceuticals and xenobiotics on renal health and function. The effects on kidney of fibres, proteins, fatty acids, curcumin, steviol glycosides, green tea, coffee, nitrates, nitrites, and alcohol, both direct and indirect, in CKD and non-CKD condition, are reviewed here. In a view of a functional and personalized nutrition, understanding the renal and systemic effects of dietary components is essential since many chronic conditions and CKD are related to systemic dysfunctions such as chronic low-grade inflammation.

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The modulation effects of plant‐derived bioactive ingredients on chronic kidney disease: Focus on the gut–kidney axis

et al. 2023

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Chronic kidney disease (CKD) results mainly from diabetes, hypertension, and glomerulonephritis, which can develop into end-stage renal disease and CKD-related complications, thereby causing high morbidity and mortality. This progression is correlated with pathogenic alterations in the gut microbiota that generate uremic toxins, mainly including indoxyl sulfate, p-cresol sulfate, and trimethylamine-N-oxide. The uremic toxins directly or indirectly induce CKD through oxidative stress, inflammatory response, and subsequently renal fibrosis. However, ongoing developments in CKD therapy still lack nutritional guidelines and new pharmacotherapies with significant effects. In this review, we discuss the modulatory effects of plant-derived bioactive ingredients, such as dietary fiber (oligosaccharides and polysaccharides), polyphenols (e.g., curcumin, anthocyanins, catechins, and resveratrol), and peptides, on gut microbiota and CKD particularly from the view of the gut-kidney axis. We believe that a comprehensive understanding of the underlying mechanisms of CKD is necessary to develop new targeted therapy strategies that will benefit the prevention and treatment of CKD.

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The impact of gut microbiota on kidney function and pathogenesis

Cited by 133 publications

References 84 publications

Gut microbiota and inflammation in chronic kidney disease and their roles in the development of cardiovascular disease

Gut microbiota and inflammation in chronic kidney disease and their roles in the development of cardiovascular disease

Nutrients, Nutraceuticals and Xenobiotics Affecting Renal Health

The modulation effects of plant‐derived bioactive ingredients on chronic kidney disease: Focus on the gut–kidney axis

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