The impact of graphene oxide sheet lateral dimensions on their pharmacokinetic and tissue distribution profiles in mice

Jasim, Dhifaf; Newman, Leon; Rodrigues, Artur Filipe; Vacchi, Isabella Anna; Lucherelli, Matteo Andrea; Lozano, Neus; Ménard‐Moyon, Cécilia; Bianco, Alberto; Kostarelos, Kostas

doi:10.1016/j.jconrel.2021.08.028

Cited by 21 publications

(16 citation statements)

References 71 publications

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“…Subsequent processing or translocation would depend again on the initial physicochemical properties and functionalization of used CNMs and formation of biocorona [ 57 ]. Several studies have pointed out that the majority of intravenously administered CNMs end up in the liver and spleen [ 58 , 59 , 60 , 61 , 62 ] followed by the lungs, kidneys, blood stream and heart [ 58 , 62 , 63 , 64 ]. Compared to occupational exposure, in most cases, there was a significantly smaller or no proinflammatory response logically due to designing or choosing CNMs to be more biocompatible and bioresistant, e.g., via modification of the surface by binding polymers such as polyethylene glycol (PEG).…”

Section: Entering the Bodymentioning

confidence: 99%

Immunotoxicity of Carbon-Based Nanomaterials, Starring Phagocytes

Švadláková

Holmannová

Koláčková

et al. 2022

IJMS

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In the field of science, technology and medicine, carbon-based nanomaterials and nanoparticles (CNMs) are becoming attractive nanomaterials that are increasingly used. However, it is important to acknowledge the risk of nanotoxicity that comes with the widespread use of CNMs. CNMs can enter the body via inhalation, ingestion, intravenously or by any other route, spread through the bloodstream and penetrate tissues where (in both compartments) they interact with components of the immune system. Like invading pathogens, CNMs can be recognized by large numbers of receptors that are present on the surface of innate immune cells, notably monocytes and macrophages. Depending on the physicochemical properties of CNMs, i.e., shape, size, or adsorbed contamination, phagocytes try to engulf and process CNMs, which might induce pro/anti-inflammatory response or lead to modulation and disruption of basic immune activity. This review focuses on existing data on the immunotoxic potential of CNMs, particularly in professional phagocytes, as they play a central role in processing and eliminating foreign particles. The results of immunotoxic studies are also described in the context of the entry routes, impacts of contamination and means of possible elimination. Mechanisms of proinflammatory effect depending on endocytosis and intracellular distribution of CNMs are highlighted as well.

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Section: Entering the Bodymentioning

confidence: 99%

Immunotoxicity of Carbon-Based Nanomaterials, Starring Phagocytes

Švadláková

Holmannová

Koláčková

et al. 2022

IJMS

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“…GO is a representative two-dimensional material composed of a simple layer of carbon atoms arranged mainly in a regular hexagonal shape. Due to their unique geometric structure, GOs exhibit outstanding properties such as huge surface area, high flexibility, good dispersion in aqueous solutions, hydrophilicity, and excellent biocompatibility [ 73 , 120 ]. Additionally, GOs have been developed in the last decade for electronics, optics, sensors, and filtration, and owing to the ability of properties modulation, graphene derivatives have been used in a wide range of fields, including applications related to drug delivery systems, gene therapy and contrast agents [ 121 ].…”

Section: Property Activity Relationships For Enmsmentioning

confidence: 99%

Diverse Pathways of Engineered Nanoparticle-Induced NLRP3 Inflammasome Activation

et al. 2022

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With the rapid development of engineered nanomaterials (ENMs) in biomedical applications, their biocompatibility and cytotoxicity need to be evaluated properly. Recently, it has been demonstrated that inflammasome activation may be a vital contributing factor for the development of biological responses induced by ENMs. Among the inflammasome family, NLRP3 inflammasome has received the most attention because it directly interacts with ENMs to cause the inflammatory effects. However, the pathways that link ENMs to NLRP3 inflammasome have not been thoroughly summarized. Thus, we reviewed recent findings on the role of major ENMs properties in modulating NLRP3 inflammasome activation, both in vitro and in vivo, to provide a better understanding of the underlying mechanisms. In addition, the interactions between ENMs and NLRP3 inflammasome activation are summarized, which may advance our understanding of safer designs of nanomaterials and ENM-induced adverse health effects.

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“…However, the affection of differential lateral sizes of GOs on the renal excretion pathways has not known yet, especially, whether the proximal tubular secretion and reabsorption involves in renal elimination of GOs is seldom known. Moreover, the lateral size of GOs has been accepted as an important parameter to regulate cellular uptake and biological responses [24][25][26][27][28][29], but how the lateral dimension of GOs influence GO interactions with different renal compartments is still unclear.…”

Section: Introductionmentioning

confidence: 99%

Renal clearance of graphene oxide: glomerular filtration or tubular secretion and selective kidney injury association with its lateral dimension

et al. 2023

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Background Renal excretion is one of the major routes of nanomaterial elimination from the body. Many previous studies have found that graphene oxide nanosheets are excreted in bulk through the kidneys. However, how the lateral size affects GO disposition in the kidneys including glomerular filtration, active tubular secretion and tubular reabsorption is still unknown. Results The thin, two-dimensional graphene oxide nanosheets (GOs) was observed to excrete in urine through the kidneys, but the lateral dimension of GOs affects their renal clearance pathway and renal injury. The s-GOs could be renal excreted via the glomerular filtration, while the l-GOs were predominately excreted via proximal tubular secretion at a much faster renal clearance rate than the s-GOs. For the tubular secretion of l-GOs, the mRNA level of basolateral organic anion transporters Oat1 and Oat2 in the kidney presented dose dependent increase, while no obvious alterations of the efflux transporters such as Mdr1 and Mrp4 mRNA expression levels were observed, suggesting the accumulation of l-GOs. During the GO renal elimination, mostly the high dose of 15 mg/kg s-GO and l-GO treatment showed obvious kidney injuries but at different renal compartment, i.e., the s-GOs induced obvious glomerular changes in podocytes, while the l-GOs induced more obvious tubular injuries including necrosis of renal tubular epithelial cells, loss of brush border, cast formation and tubular dilatation. The specifically tubular injury biomarkers KIM1 and NGAL were shown slight increase with mRNA levels in l-GO administrated mice. Conclusions This study shows that the lateral size of GOs affected their interactions with different renal compartments, renal excretion pathways and potential kidney injuries.

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The impact of graphene oxide sheet lateral dimensions on their pharmacokinetic and tissue distribution profiles in mice

Cited by 21 publications

References 71 publications

Immunotoxicity of Carbon-Based Nanomaterials, Starring Phagocytes

Immunotoxicity of Carbon-Based Nanomaterials, Starring Phagocytes

Diverse Pathways of Engineered Nanoparticle-Induced NLRP3 Inflammasome Activation

Renal clearance of graphene oxide: glomerular filtration or tubular secretion and selective kidney injury association with its lateral dimension

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